Integrated Janus nanofibers enabled by a co-shell solvent for enhancing icariin delivery efficiency

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

“…For drug delivery, particularly for drugs with poor water solubilities, the amorphous state is more favorable than the crystalline state for predictable, controlled release ( Pattnaik et al, 2023 ; Sun et al, 2024 ). The XRD patterns of the four starting components (Reglan, 5-FU, PVP, and CA) and their homogeneous composite S2, heterogeneous composite S3, and hybrid casting films S4 are shown in Figure 6 .…”

Versatile Hyper-Cross-Linked Polymers Derived from Waste Polystyrene: Synthesis, Properties, and Intentional Recycling

“…Processing in thin film form not only reduces the risk of particles clogging in pipes or equipment but also facilitates recycling. Some effective forming schemes such as electrospinning, − spin coating, solution casting and so on, these approaches not only improve the process controllability and manufacturing efficiency of materials but also allow for customized modulation of the morphology and properties of WPS-HCP to meet the requirements of different application scenarios, thus provides the material development and application of the possibility of a vast and flexibility.…”

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

“…Previous studies showed that CDs show a unique identification peak at 1.03 ppm (−CH 3 ). 28 The identification peaks of quercetin are between 6.1 and 7.7 ppm, which are attributed to the two rings of the quercetin molecule (as shown in Figure 5). 33 Considering the difference between the integration of quercetin and CD peaks, the CD/ Quercetin molar ratio in HP-β-CD/Quercetin (8:1), HP-γ-CD/Quercetin (8:1), and Chitosan/HP-γ-CD/Quercetin (8:1) nanofibers was found to be 7.46/1, 7.81/1, and 7.74/ 1, respectively.…”

“…27 However, it is challenging to enhance the solubility of some poorly water-soluble drugs due to the lack of suitable solvents, resulting in their diminished activity. 28 The application of cyclodextrins (CDs) has become a very effective strategy to deal with the low solubility of quercetin. The capability of CDs, which are cyclic oligosaccharides with a hydrophobic core and a hydrophilic outside, to form noncovalent inclusion complexes is well-known.…”