Integrated imaging of non-small cell lung cancer recurrence: CT and PET-CT findings, possible pitfalls and risk of recurrence criteria

Caulo, Andrea; Mirsadraee, Saeed; Maggi, Fabio; Leccisotti, Lucia; Beek, Edwin Jacques Rudolph van; Bonomo, Lorenzo

doi:10.1007/s00330-011-2299-8

Cited by 32 publications

(18 citation statements)

References 86 publications

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“…Quantitative methods to measure tumor heterogeneity have been shown to play a role in the assessment of cancer response to therapy101112. Intratumor heterogeneity measured by texture parameters on non-enhanced and/or contrast material-enhanced CT images between baseline and initial post-therapy have been associated with overall survival (OS) in patients with colorectal cancer13, metastatic renal cell cancer14, esophageal cancer15, and NSCLC16171819.…”

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confidence: 99%

Non-small cell lung cancer: quantitative phenotypic analysis of CT images as a potential marker of prognosis

Song

Liu

Zhong

et al. 2016

Sci Rep

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This was a retrospective study to investigate the predictive and prognostic ability of quantitative computed tomography phenotypic features in patients with non-small cell lung cancer (NSCLC). 661 patients with pathological confirmed as NSCLC were enrolled between 2007 and 2014. 592 phenotypic descriptors was automatically extracted on the pre-therapy CT images. Firstly, support vector machine (SVM) was used to evaluate the predictive value of each feature for pathology and TNM clinical stage. Secondly, Cox proportional hazards model was used to evaluate the prognostic value of these imaging signatures selected by SVM which subjected to a primary cohort of 138 patients, and an external independent validation of 61 patients. The results indicated that predictive accuracy for histopathology, N staging, and overall clinical stage was 75.16%, 79.40% and 80.33%, respectively. Besides, Cox models indicated the signatures selected by SVM: “correlation of co-occurrence after wavelet transform” was significantly associated with overall survival in the two datasets (hazard ratio [HR]: 1.65, 95% confidence interval [CI]: 1.41–2.75, p = 0.010; and HR: 2.74, 95%CI: 1.10–6.85, p = 0.027, respectively). Our study indicates that the phenotypic features might provide some insight in metastatic potential or aggressiveness for NSCLC, which potentially offer clinical value in directing personalized therapeutic regimen selection for NSCLC.

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confidence: 99%

Non-small cell lung cancer: quantitative phenotypic analysis of CT images as a potential marker of prognosis

Song

Liu

Zhong

et al. 2016

Sci Rep

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“…FDG-PET plays an important role in the identification of lung cancer recurrence. 17) A desmoid-type fibromatosis arising from a thoracotomy scar mimics the chest wall or pleural recurrence of lung cancer. Although lung cancer with recurrence exhibits high FDG accumulation on PET, the tumor in cases of desmoid-type fibromatosis following thoracotomy exhibited mild FDG accumulation in PET analysis (SUV max : 2.7-2.8, Table 1).…”

Section: Discussionmentioning

confidence: 99%

A Case of Desmoid-Type Fibromatosis Arising after Thoracotomy for Lung Cancer with a Review of the English and Japanese Literature

Mori

Yamada

Ohba

et al. 2014

Ann Thorac Cardiovasc Surg

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Chest wall desmoid-type fibromatoses are rare tumors 1) that occasionally arise from thoracotomy scars. 2,3) They are locally aggressive tumors that occasionally exhibit local recurrence after resection. 4) Desmoid tumors arising from thoracotomy scars in patients with lung cancer should be discriminated from chest wall recurrence or dissemination of lung cancer. To address this issue, we present our case and review cases of desmoid-type fibromatosis following a previous thoracotomy that were reported in English or Japanese. Case ReportA 62-year-old woman was found to have a chest wall tumor on chest computed tomography (CT) at a 1-year routine follow-up after video-assisted thoracoscopic segmentectomy for pT1aN0M0 lung adenocarcinoma. The tumor was 3.4 × 1.3 cm in size, and it was located in the previous thoracotomy site (Fig. 1A). Positron emission tomography (PET) revealed mild 18 F-fluorodeoxyglucose (FDG) accumulation in the tumor, with a maximal standardized uptake value (SUV max ) of 1.9. There was no effusion or other lesions on CT and PET. She had no apparent elevation of carcinoembryonic antigen (CEA; 1.9 ng/ml [normal range, <2.0 ng/ml]) compared to the preoperative CEA value of 1.3 ng/ml. CT-guided A Case of Desmoid-Type Fibromatosis Arising after Thoracotomy for Lung Cancer with a Review of the English and Japanese LiteratureTakeshi Mori, MD, PhD, Tatsuya Yamada, MD, Yasuomi Ohba, MD, PhD, Kentaro Yoshimoto, MD, PhD, Koei Ikeda, MD, PhD, Kenji Shiraishi, MD, PhD, and Makoto Suzuki, PhD, MD Chest wall desmoid-type fibromatoses are rare, locally aggressive tumors that occasionally arise from previous thoracotomy sites. Tumors arising from previous sites of thoracotomy to treat malignant disease should be discriminated from the pleural dissemination of the previous malignancy. In this study, we report a case of desmoid-type fibromatosis arising from a site for thoracotomy to treat lung cancer. Additionally we reviewed 15 reported cases of desmoid-type fibromatosis following thoracotomy and summarized their features. A 62-year-old woman was found to have a tumor on computed tomography (CT) at a 1-year routine checkup for lung cancer. The tumor (diameter, 3.4 cm) was located at the previous thoracotomy site. Positron emission tomography (PET) revealed mild 18 F-fluorodeoxyglucose (FDG) accumulation in the tumor, with a maximal standardized uptake value (SUV max ) of 1.9. CT-guided biopsy revealed only fibrous tissue. Eighteen months after the biopsy, CT revealed apparent tumor growth, and a biopsy revealed the same histology observed previously. The tumor was removed and diagnosed as desmoid-type fibromatosis. Currently, the patient is alive without recurrence 4 years after desmoid surgery.

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“…[52][53][54] In addition to primary tumor staging, 18 F-FDG PET-CT has been shown to be superior to standard CT and MRI for the detection of recurrent disease after surgery, local ablative therapies such as microwave ablation and chemotherapy. [55][56][57][58][59][60][61][62][63][64] According to the Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) guidelines, a reduction in 18 F-FDG PET uptake of 30% is defined as a metabolic response, whereas an increase of 30% is defined as progression. 65 Moreover, 18 F-FDG PET-CT defines more precisely the target volumes for both, conventional as well as stereotactic radiotherapy planning.…”

Section: Dynamic Contrast-enhanced Ctmentioning

confidence: 99%

Perspectives of Novel Imaging Techniques for Staging, Therapy Response Assessment, and Monitoring of Surveillance in Lung Cancer: Summary of the Dresden 2013 Post WCLC-IASLC State-of-the-Art Imaging Workshop

Henzler

Goldstraw

Wenz

et al. 2015

Journal of Thoracic Oncology

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Modern imaging techniques that can provide functional information on tumor vascularization, metabolic activity, or cellularity have seen significant improvements over the past decade. However, most of these techniques are currently not broadly utilized neither in clinical trials nor in clinical routine, although there is a large agreement on the fact that conventional approaches for therapy response assessment such as Response Evaluation Criteria in Solid Tumors or World Health Organization criteria-that exclusively focus on the change in tumor size-are of less value for response assessment in modern thoracic oncology. The aim of this article comprises two parts: a short review of the most promising state-of-the-art imaging techniques that have the potential to play a larger role in thoracic oncology within the near future followed by a meeting report including recommendations of an interdisciplinary expert panel that discussed the potential of the different techniques during the Dresden 2013 Post World Congress of Lung Cancer (WCLC)--International Association for the Study of Lung Cancer (IASLC) meeting. It is intended to provide a comprehensive summary about ongoing trends and future perspectives on functional imaging in thoracic oncology.

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Integrated imaging of non-small cell lung cancer recurrence: CT and PET-CT findings, possible pitfalls and risk of recurrence criteria

Abstract: Lung cancer recurs after surgery in 30% to 75% of patients. CT and PET-CT are crucial in identification of loco-regional recurrence. Knowledge of potential pitfalls is essential, espe… Show more

Cited by 32 publications

References 86 publications

Non-small cell lung cancer: quantitative phenotypic analysis of CT images as a potential marker of prognosis

Non-small cell lung cancer: quantitative phenotypic analysis of CT images as a potential marker of prognosis

A Case of Desmoid-Type Fibromatosis Arising after Thoracotomy for Lung Cancer with a Review of the English and Japanese Literature

Perspectives of Novel Imaging Techniques for Staging, Therapy Response Assessment, and Monitoring of Surveillance in Lung Cancer: Summary of the Dresden 2013 Post WCLC-IASLC State-of-the-Art Imaging Workshop

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