Background The potential for natural disasters in Bengkulu Province is very worrying. Muko-muko is one of the districts in Bengkulu Provention which has a geographical location prone to earthquakes and stunami. Preparedness and disaster mitigation in school students is still low. Members of the Palang Merah Remaja (PMR) in senior high schools have never been exposed to disaster management.Objective The aims of this study was to determine Effect of Health Promotion to Knowledge about Disaster Management on Students of Palang Merah Remaja (PMR) at SMA Negeri 1 Mukomuko. This study used pre and post test without control group design. Population in this study were all students of of Palang Merah Remaja (PMR) at SMA Negeri 1 Mukomuko Bengkulu with the amount of 30 people. Sampling technique in this study used total sampling obtained samples were 30 people. Collecting data in this study used primary data obtained from SMA Negeri 1 Mukomuko and secondary data with filled out questionnaire.MethodsThe results of this study showed: (1) from 30 people there were 13 people (43,3%) before treatment were good knowledge, 16 people (53,3%) before treatment were moderate knowledge, and 1 people (3,3%) before treatment were lack knowledge; (2) from 30 people there were 18 people (60%) after treatment were good knowledge and 12 people (40%) after treatment were moderate knowledge; (3) results of Paired Sample t-test obtained value of t = 3,023 with p-value = 0,005<0,05 significant means there was significant diffrences between knowledge about Disaster Management on Students before treatment and knowledge about Disaster Management on Students after treatment.ConclusionThe importance of direct information from health workers regarding disaster management has a continuing impact to be applied by PMR students when a disaster occurs. Keywords: Health Promotion, Knowledge, Disaster Management