Integrated gut microbiota and fecal metabolomics reveal the renoprotective effect of Rehmanniae Radix Preparata and Corni Fructus on adenine-induced CKD rats

Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats

“…After PCM overdose induction, the five top genera in the model group were Intestinibacter, Lactobacillus, Bifidobacterium, Ruminococcaceae_UCG-014 and Enterorhabdus , suggesting intestinal flora disturbed to some extent by PCM overdose. The abundance of beneficial bacterium Lactobacillus was markedly elevated in the model group as compared to that in the CK group; however, beneficial bacteria such as Bifidobacterium and Lachnospiraceae_NK4A136_group 42,44 were decreased after PCM overdose induction. In addition, opportunistic pathogens such as Desulfovibrio and Streptococcus 44,45 were increased in the model group.…”

“…The abundance of beneficial bacterium Lactobacillus was markedly elevated in the model group as compared to that in the CK group; however, beneficial bacteria such as Bifidobacterium and Lachnospiraceae_NK4A136_group 42,44 were decreased after PCM overdose induction. In addition, opportunistic pathogens such as Desulfovibrio and Streptococcus 44,45 were increased in the model group. Our findings indicated the intestinal flora self-regulation to various degrees to resist the external drug damage; however, most beneficial bacteria were markedly decreased.…”

“…A parameter VIP (variable importance in the projection) with a large score > 1 is used to explain the most relevant classification. 44 In this study, eighty metabolites with VIP ≥ 1 and p -value ≤ 0.05 were putatively identified as potential biomarkers to distinguish the plasma metabolites of N-Asta- vs. S-Asta-pre-treated groups.…”

Changes in the Chemical Components of Processed Rehmanniae Radix Distillate during Different Steaming Times

“…PRR is a product of RR obtained by steaming the dried root with rice wine followed by sun-drying for nine cycles, and in doing so not only could that change the character and taste, according to the quality standard of “black as paint, sweet as wheat,” but it also enhanced the effect of nourishing yin and reinforcing the kidney [ 2 ]. It is believed to be efficient in enriching yin and reinforcing the kidney in Traditional Chinese Medicine (TCM), prevent osteoporosis [ 3 , 4 ], possess renoprotective activity [ 5 , 6 ], and prevent cardiovascular diseases [ 7 ]. It has become one of the most popular dietary supplements for healthcare [ 8 ].…”

The Herb Pair Radix Rehmanniae and Cornus Officinalis Attenuated Testicular Damage in Mice With Diabetes Mellitus Through Butyric Acid/Glucagon-Like Peptide-1/Glucagon-Like Peptide-1 Receptor Pathway Mediated by Gut Microbiota

“…Extracts of CO have been demonstrated to exhibit curative hypoglycemic effects and selectively modulate GM in T2DM mice ( Niu et al, 2020 ). Zhang et al (2021c) implied that GM and their metabolites might play a vital role in the progression of chronic kidney disease, which was reversed by the treatment with Rehmannia Radix Preparata and CO herb pair. However, hitherto, the research on the gut-testis axis in metabolic diseases is still limited.…”