Integrated Functions of Cardiac Energetics, Mechanics, and Purine Nucleotide Metabolism
Rachel Lopez‐Schenk,
Nicole L. Collins,
Noah A. Schenk
et al.
Abstract:Purine nucleotides play central roles in energy metabolism in the heart. Most fundamentally, the free energy of hydrolysis of the adenine nucleotide adenosine triphosphate (ATP) provides the thermodynamic driving force for numerous cellular processes including the actin‐myosin crossbridge cycle. Perturbations to ATP supply and/or demand in the myocardium lead to changes in the homeostatic balance between purine nucleotide synthesis, degradation, and salvage, potentially affecting myocardial energetics and, con… Show more
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