2011
DOI: 10.4061/2011/587303
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Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project

Abstract: This work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people with nonphysiological and pathological conditions were excluded. Then, we excluded subjects with (a) cardiovascular (CV) symptoms, (b) CV disease, (c) diabetes mellitus or renal failure, and (d) traditional CV risk… Show more

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Cited by 30 publications
(36 citation statements)
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“…When using synthesized aortic pressure waves from the GTF approach and brachial pressures obtained from an oscillometric cuff as done in the Anglo-Cardiff Collaborative Trial (ACCT), amplifi cation varies from 1.7 in the young (<20 years of age) to 1.2 in the elderly (>80 years of age) [ 123 ]. These results are similar to those reported by Bia et al [ 127 ] over the same age range in the CUiiDARTE Project and those collected by Nichols et al [ 3 ]. When carotid and/or radial pressure waves obtained from applanation tonometry are calibrated against brachial diastolic and tonometric mean pressures (the latter being obtained from a brachial artery tonometric waveform), as was done in the Asklepios Study, PP amplifi cation values tend to be lower [ 116 ].…”
Section: Pressure Differences Within the Arterial Tree And Pulse Pressupporting
confidence: 82%
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“…When using synthesized aortic pressure waves from the GTF approach and brachial pressures obtained from an oscillometric cuff as done in the Anglo-Cardiff Collaborative Trial (ACCT), amplifi cation varies from 1.7 in the young (<20 years of age) to 1.2 in the elderly (>80 years of age) [ 123 ]. These results are similar to those reported by Bia et al [ 127 ] over the same age range in the CUiiDARTE Project and those collected by Nichols et al [ 3 ]. When carotid and/or radial pressure waves obtained from applanation tonometry are calibrated against brachial diastolic and tonometric mean pressures (the latter being obtained from a brachial artery tonometric waveform), as was done in the Asklepios Study, PP amplifi cation values tend to be lower [ 116 ].…”
Section: Pressure Differences Within the Arterial Tree And Pulse Pressupporting
confidence: 82%
“…Major changes in aortic pressure wave contour are due to alterations in amplitude and timing of wave refl ections from the macrocirculation, including both elastic and muscular arteries (including arterioles). LV afterload, central aortic and brachial artery systolic, and PP, SPTI, RM, and AIx are increased by elastic artery stiffening and increased wave refl ection amplitude, all of which are alterations associated with aging and resulting in LVH [ 60 , 131 ] and arterial wall damage [ 127 ]-major cardiovascular, cerebrovascular, and renovascular risk factors [ 56 , 154 , 155 ]. Major cardiovascular risk factors resulting from increased aortic stiffness and wave refl ection (LV afterload) include coronary artery atherosclerosis, decreased coronary blood fl ow and coronary fl ow reserve (CFR) (Fig.…”
Section: Components Of the Central Aortic Pressure Wavementioning
confidence: 99%
“…CUiiDARTE Center and Project is a Uruguayan Interdisciplinary University Program for Arterial Disease Early Diagnosis focused on children and adults, supported by the Republic University, the Ministry of Public Health and the National Agency for Research and Innovation (ANII) [18,19] . Using the CUiiDARTE Project database, a total of 384 asymptomatic healthy subjects were selected to comprise the control group.…”
Section: Subjects and Groupsmentioning
confidence: 99%
“…To this end, carotid and femoral artery waveforms were recorded using high-fidelity mechano-transducers simultaneously placed on the skin over the carotid and femoral arteries, keeping the patients in the supine position (Arteriometer, Model V100, Oxytech, Buenos Aires, Argentina) [18,[22][23][24] ( fig. 1 ).…”
Section: Data Acquisitionmentioning
confidence: 99%
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