Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala

Han, Wenfei; Téllez, Luis A.; Rangel, Miguel J.; Motta, Simone Cristina; Zhang, Xiaobing; Perez, Isaac O.; Canteras, Newton S.; Shammah‐Lagnado, Sara J.; Pol, Anthony N. van den; Araújo, Ivan E. de

doi:10.1016/j.cell.2016.12.027

Cited by 243 publications

(230 citation statements)

References 45 publications

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“…This interpretation provides a neuroanatomic substrate for the proposal by Schachter and Singer of cognitive and physiological determinants of emotional feelings about a half century ago (Schachter et al, 1962). Recent ontogenetic experiments have also supported a role of the central nucleus of the amygdala in predatory behavior (Han et al, 2017). …”

Section: 12 Central Neural Hierarchiesmentioning

confidence: 97%

Homeostatic systems, biocybernetics, and autonomic neuroscience

Goldstein

Kopin²

2017

Autonomic Neuroscience

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In this review we describe a series of major concepts introduced during the past 150 years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that hierarchical networks involving input-output relationships continuously orchestrate and learn adaptive patterns of observable behaviors, cognition, memory, mood, and autonomic systems. Taken together, these networks function as “good regulators” determining levels of internal variables and act as if there were homeostatic comparators (“homeostats”). The consequences of models with vs. without homeostats remain the same in terms of allostatic load and the eventual switch from stabilizing negative feedback loops to destabilizing, pathogenic positive feedback loops. Understanding this switch seems important for comprehending senescence-related, neurodegenerative disorders that involve the autonomic nervous system. Our general proposal is that disintegration of homeostatic systems causes disorders of regulation in degenerative diseases and that medical cybernetics can inspire and rationalize new approaches to treatment and prevention.

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Section: 12 Central Neural Hierarchiesmentioning

confidence: 97%

Homeostatic systems, biocybernetics, and autonomic neuroscience

Goldstein

Kopin²

2017

Autonomic Neuroscience

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“…A population of neurons within the central amygdala has recently been shown to mediate mouse predatory behaviour 152 . However, as in the other limbic regions discussed above, parallel, opposing pathways that mediate antithetical behavioural responses are likely to exist within both of these regions.…”

Section: Altered Arousal and Reactivitymentioning

confidence: 99%

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

et al. 2018

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Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.

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“…Furthermore, in many species PBg plays a role in competitive stimulus selection (Mysore and Knudsen, 2011) that may be involved in selecting one target within the visual field. Providing input to both deep SC and PBg could therefore simultaneously guide motor output during approach and facilitate selection/pursuit of a single target (Evans et al, 2018;Han et al, 2017;Li et al, 2018) . Thus, our findings are consistent with NF cells driving the visually-guided motor output needed for continuous and accurate targeting of prey.…”

Section: Specific Cell Types and Circuits Within The Ssc Contribute Tmentioning

confidence: 99%

Defined cell types in superior colliculus make distinct contributions to prey capture behavior in the mouse

Hoy

Bishop

Niell

2019

Preprint

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The superior colliculus (SC) mediates rapid orienting to visual stimuli across species. To determine the specific circuits within the SC that drive orienting and approach behavior toward appetitive stimuli, we explored the role of three genetically defined cell types in mediating prey capture in mice. Chemogenetic inactivation of two classically defined cell types, the wide-field (WF) and narrow-field (NF) vertical neurons, revealed that they are involved in distinct aspects of prey capture. WF neurons were required for rapid prey detection and distant approach initiation, whereas NF neurons were required for continuous and accurate orienting during pursuit. In contrast, prey capture did not require parvalbumin-expressing (PV) neurons that have previously been implicated in fear responses. The visual coding of WF and NF cells in the awake mouse and their projection targets were consistent with their roles in prey detection versus pursuit. Thus, our studies link specific neural circuit connectivity and function with stimulus detection and orienting behavior, providing insight into visuomotor and attentional mechanisms mediated by superior colliculus. Highlights• This study provides the first demonstration of the role of specific cell populations in the superior colliculus in orienting and approach behavior.• A genetically targeted population of wide-field vertical neurons in the superior colliculus is required for rapid prey detection and initiation of long-distance approaches.• A genetically targeted population of narrow-field vertical neurons is required for approach initiation, accurate targeting, and approach continuity.• Visual response properties and projection targets of these cells are consistent with their role in prey capture, linking neural circuit connectivity and function with behavior.

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Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala

Cited by 243 publications

References 45 publications

Homeostatic systems, biocybernetics, and autonomic neuroscience

Homeostatic systems, biocybernetics, and autonomic neuroscience

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

Defined cell types in superior colliculus make distinct contributions to prey capture behavior in the mouse

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