Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac<sup>TM</sup>

Rodriguez-Valle, M.; Méndez, Luis; Valdez, Mario García; Redondo, María C.; Espinosa, Carlos Montero; Vargas, Milagro; Cruz, Ricardo Lleonart; Barrios, Humberto perez; Seoane, G; Ramirez, Emerio serrano; Boué, Oscar; Vigil, Jorge Lodos; Machado, Humberto; Nordelo, Carlos Borroto; Piñeiro, Marisdania Joglar

doi:10.1023/b:appa.0000049223.92326.02

Cited by 5 publications

(8 citation statements)

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“…Effectively, vaccines are an additional tool in the tick-control arsenal. In a study conducted in Cuba (RODRIGUEZ-VALLE et al, 2004), this approach was taken with the Gavac vaccine, and the use of such vaccine resulted in an increase in the interval between acaricide treatments in Bos taurus and an 87% decrease in the total number of acaricide treatments required. Similar results were obtained in B. indicus, in which there was also an increase in the interval between acaricide treatments, together with a 68% decrease in the total number of acaricide treatments required (RODRIGUEZ-VALLE et al, 2004).…”

Section: Integrated Control Of R Microplus With Gavac and Acaricidesmentioning

confidence: 99%

“…In a study conducted in Cuba (RODRIGUEZ-VALLE et al, 2004), this approach was taken with the Gavac vaccine, and the use of such vaccine resulted in an increase in the interval between acaricide treatments in Bos taurus and an 87% decrease in the total number of acaricide treatments required. Similar results were obtained in B. indicus, in which there was also an increase in the interval between acaricide treatments, together with a 68% decrease in the total number of acaricide treatments required (RODRIGUEZ-VALLE et al, 2004). In another study, conducted in Mexico, Gavac vaccine was used in combination with an amidine for the control of R. microplus, resulting in a lower number of acaricide treatments in cattle that had received the anti-tick vaccine (REDONDO et al, 1999).…”

Section: Integrated Control Of R Microplus With Gavac and Acaricidesmentioning

confidence: 99%

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Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Silva,

Ali,

Termignoni

et al. 2024

Cienc. Rural

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Rhipicephalus (Boophilus) microplus is a hard tick endemic in livestock-growing regions and causes economic losses in the largest beef-producing countries, including Brazil, Mexico, Argentina, Australia and Uruguay. The use of chemical acaricides is still the main strategy to control R. microplusinfestations. Nevertheless, immunological control of R. microplus with an anti-tick vaccine is a suitable alternative and has manifold advantages because it can avoid drug-resistance and the presence of acaricide residues in milk, beef and in the environment. Indeed, vaccines based on the Bm86 antigen have had relative commercial and technical success to control R. microplus in some regions. Although, the efficacy of such vaccines varies among tick populations and is insufficient to provide an acceptable level of protection. Therefore, the need to search for better antigens is impelling. This review focused on the restrictions imposed on the use of acaricides in Brazil and in the European Union, as well as on the impacts of Bm86-based vaccines on R. microplus control. The efficacy of experimental anti-tick vaccines (based on subolesin, glutathione S-transferase, ferritin 2; voltage-dependent anion channel; aquaporin, 60 S acidic ribosomal protein, metalloprotease and trypsin) that can elicit an immune response against the physiological functions of various ticks is discussed.

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Section: Integrated Control Of R Microplus With Gavac and Acaricidesmentioning

confidence: 99%

Section: Integrated Control Of R Microplus With Gavac and Acaricidesmentioning

confidence: 99%

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Silva,

Ali,

Termignoni

et al. 2024

Cienc. Rural

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“…In an animal clinical study, almost 600,000 dairy cattle were vaccinated, and the use of the vaccine reduced the number of clinical cases of babesiosis from 54 to 1.9 cases per 1,000 cattle. Accordingly, the mortality rate dropped from 6 to 0.18 cases per 1000 cattle, making the vaccine one of the strongest tools for preventing the economic loss caused by babesiosis (Valle et al 2004 ). Gavac™ is based on the same peptide as the older Australian vaccine named TickGard(PLUS).…”

Section: Vaccination Against Ticks and Tick-borne Diseasesmentioning

confidence: 99%

Prevention of tick-borne diseases: challenge to recent medicine

Hromníková

Furka

et al. 2022

Biologia

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Ticks represent important vectors and reservoirs of pathogens, causing a number of diseases in humans and animals, and significant damage to livestock every year. Modern research into protection against ticks and tick-borne diseases focuses mainly on the feeding stage, i.e. the period when ticks take their blood meal from their hosts during which pathogens are transmitted. Physiological functions in ticks, such as food intake, saliva production, reproduction, development, and others are under control of neuropeptides and peptide hormones which may be involved in pathogen transmission that cause Lyme borreliosis or tick-borne encephalitis. According to current knowledge, ticks are not reservoirs or vectors for the spread of COVID-19 disease. The search for new vaccination methods to protect against ticks and their transmissible pathogens is a challenge for current science in view of global changes, including the increasing migration of the human population. Highlights • Tick-borne diseases have an increasing incidence due to climate change and increased human migration • To date, there is no evidence of transmission of coronavirus COVID-19 by tick as a vector • To date, there are only a few modern, effective, and actively- used vaccines against ticks or tick-borne diseases • Neuropeptides and their receptors expressed in ticks may be potentially used for vaccine design

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“…However, only a few of these molecules provide the host with a significant level of immunity against tick-borne pathogens. One of the successful commercial vaccines, TickGARD, based on tick antigen Bm86, was utilized in Australia and Latin American countries against Rhipicephalus microplus infestations (Bowman et al, 2004;Valle et al, 2004;de la Fuente et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Targeting Haemaphysalis longicornis serpin to prevent tick feeding and pathogen transmission

Feng,

Tong,

Zhang

et al. 2023

Insect Science

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Serine proteinase inhibitors (serpins), identified from the hard tick Haemaphysalis longicornis of China, play significant roles in various animal physiological processes. In this study, we showed that H. longicornis serpins (Hlserpin‐a and Hlserpin‐b) were induced during blood‐feeding in nymph ticks and exhibited anticoagulation activity in vitro. Silencing Hlserpins through RNA interference (RNAi) significantly impaired tick feeding. Immunization of mice with recombinant Hlserpins or passive transfer of Hlserpin antiserum significantly curtails the efficacy of tick feeding. Concurrently, the transmission of the Langat virus (LGTV) from ticks to mice witnessed a substantial decrease when Hlserpins were silenced. Our findings suggest that inhibiting Hlserpins can hamper tick engorgement and pathogen transmission, indicating the potential of Hlserpins as a vaccine to counter tick‐borne diseases.

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Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac^TM

Cited by 5 publications

References 0 publications

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Prevention of tick-borne diseases: challenge to recent medicine

Targeting Haemaphysalis longicornis serpin to prevent tick feeding and pathogen transmission

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Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine GavacTM

Cited by 5 publications

References 0 publications

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Prevention of tick-borne diseases: challenge to recent medicine

Targeting Haemaphysalis longicornis serpin to prevent tick feeding and pathogen transmission

Contact Info

Product

Resources

About

Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac^TM