Integrated Chinese Herbal Medicine and Western Medicine on the Survival in Patients with Colorectal Cancer: A Retrospective Study of Medical Records

Yeh, Ming-Hsien; Chiu, Hung-Sheng; Wu, Maochun; Koo, Malcolm; Lin, Nai-Wei; Liao, Kou-Kai; Yeh, Chia-Chou; Li, Te‐Mao

doi:10.1155/2020/4561040

Cited by 11 publications

(4 citation statements)

References 34 publications

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“…Based on the cumulative use of CHMs for 6 months, we divided patients into an integrated Chinese and Western medicine or Western medicine group [ 19 ]. When two consecutive CHM treatments were >6 weeks apart, CHMs were considered discontinued [ 20 ]. Patients using CHMs for >5 years without CRC R&M were defined as the TCM “target population.” When stratified according to CHM use, the “worst cases” were defined as patients who had R&M after taking TCM for ≥6 months.…”

Section: Methodsmentioning

confidence: 99%

Association between Oral Chinese Herbal Medicine and Recurrence and Metastasis in Patients with Stages II and III Colorectal Cancer: A Cohort Study in China

Tang

Zhang

Qin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. To evaluate the associations between long-term oral Chinese herbal medicines (CHMs) and recurrence and metastasis (R&M) in patients with stage II and III colorectal cancer (CRC). Furthermore, we aimed to determine the correlation between different syndrome patterns and prognosis and summarized the regularities among CHMs prescriptions, providing reference for clinical practice. Methods. An ambispective cohort study was conducted. All CRC patients who sought evaluation and treatment at Xiyuan Hospital and Beijing Cancer Hospital from August 2014 to August 2016 were included. In this study, “whether patients voluntarily take CHMs” was taken as the exposure factor, and the exposure degree was “the duration of CHM use.” Stratification was performed according to the duration of TCM use to determine the relationship with R&M of CRC. The primary outcome was disease-free survival. Patients who had R&M of CRC after taking CHMs for ≥6 months were defined as “worst patients.” R software was used for statistical analysis. The Kaplan–Meier method and Cox regression analysis were used to determine the prognosis. IBM SPSS was used to model a priori association rules; drug use rules were analyzed on this basis. Results. A total of 186 patients with stage II and III CRC after radical resection were enrolled. All patients reached the study endpoint by August 2021. The difference in disease-free survival between the two groups was most significant when the cutoff value for CHMs was 18 months ( P = 0.0012 ). Multivariate analysis showed that 18 CHMs were independent protective factors for R&M of CRC ( P = 0.001 , HR = 0.20, 95% CI = 0.08–0.53). The ratio of Pi (spleen) and Shen (kidney) deficiency in the worst cases was higher than patients without R&M ( P = 0.018 ). Sijunzi and Liuwei Dihuang decoctions were the most frequently used prescriptions in the anti-R&M phase. Conclusion. CHMs complying with the “Jianpi Bushen” principle may attenuate the risk of R&M in patients with stage II and III CRC. Pi (spleen) and Shen (kidney) deficiency in patients receiving TCM intervention for the first time within 6 months of radical resection may be associated with a higher CRC R&M rate. Further research is warranted to validate these findings and elucidate underlying biological mechanisms.

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Section: Methodsmentioning

confidence: 99%

Association between Oral Chinese Herbal Medicine and Recurrence and Metastasis in Patients with Stages II and III Colorectal Cancer: A Cohort Study in China

Tang

Zhang

Qin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, it is necessary to develop new and neo-adjuvant therapies in combination with other chemotherapeutics. TCMs and their active compounds with multi-targets was reported to prevent and treat CRC patients as promising candidates, which is distinct from small molecular inhibitors that depend on single target ( Yeh et al, 2020 ). In addition, because of relatively lower toxicity and cheaper price, TCMs can be more accepted by patients with CRC physically and psychologically.…”

Section: Effect Of Tcm Formulas On Crcmentioning

confidence: 99%

Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy

et al. 2021

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Colorectal cancer (CRC) has become a global public health problem because of its high incidence and mortality rate worldwide. The previous clinical treatment for CRC mainly involves conventional surgery, chemotherapy, and radiotherapy. With the development of tumor molecular targeted therapy, small molecule inhibitors present a great advantage in improving the survival of patients with advanced CRC. However, various side effects and drug resistance induced by chemotherapy are still the major obstacles to improve the clinical benefit. Thus, it is crucial to find new and alternative drugs for CRC treatment. Traditional Chinese medicines (TCMs) have been proved to have low toxicity and multi-target characteristics. In the last few decades, an increasing number of studies have demonstrated that TCMs exhibit strong anticancer effects in both experimental and clinical models and may serve as alternative chemotherapy agents for CRC treatment. Notably, Wnt/β-catenin signaling pathway plays a vital role in the initiation and progression of CRC by modulating the stability of β-catenin in the cytoplasm. Targeting Wnt/β-catenin pathway is a novel direction for developing therapies for CRC. In this review, we outlined the anti-tumor effects of small molecular inhibitors on CRC through Wnt/β-catenin pathway. More importantly, we focused on the potential role of TCMs against tumors by targeting Wnt/β-catenin signaling at different stages of CRC, including precancerous lesions, early stage of CRC and advanced CRC. Furthermore, we also discussed perspectives to develop potential new drugs from TCMs via Wnt/β-catenin pathway for the treatment of CRC.

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“…For this reason, the doctors practicing Traditional Chinese Medicine have long relied on examining the tongue to diagnose illnesses and prescribe treatments [2,12]. In recent years, western medicine has also increasingly embraced this practice, with some doctors incorporating tongue examination into their clinical protocol [13][14][15][16]. Despite the clinical importance of the tongue, scientific understanding of the tongue's role in diagnosis has been lacking.…”

Section: Introductionmentioning

confidence: 99%

Using advanced convolutional neural network approaches to reveal patient age, gender, and weight based on tongue images

Wei

et al. 2023

Preprint

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The human tongue has been long believed to be a window to provide important insights into a patient's health in medicine. The present study introduced a novel approach to predict patient age, gender, and weight inferences based on tongue images using pre-trained deep CNNs. Our results demonstrated that the deep CNN models trained on dorsal tongue images produced excellent results for age prediction with a Pearson correlation coefficient of 0.71 and a mean absolute error of 8.5 years. We also obtained an excellent classification of gender, with a mean accuracy of 80% and an AUC of 88%. The model also obtained a moderate level of accuracy for weight prediction, with a Pearson correlation coefficient of 0.39 and a mean absolute error of 9.06 kilograms. These findings support our hypothesis that the human tongue contains crucial information about a patient. This study demonstrated the feasibility of using the pre-trained deep CNNs along with a large tongue image dataset to develop computational models to predict patient medical conditions for non-invasive, convenient, and inexpensive patient health monitoring and diagnosis.

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Integrated Chinese Herbal Medicine and Western Medicine on the Survival in Patients with Colorectal Cancer: A Retrospective Study of Medical Records

Cited by 11 publications

References 34 publications

Association between Oral Chinese Herbal Medicine and Recurrence and Metastasis in Patients with Stages II and III Colorectal Cancer: A Cohort Study in China

Association between Oral Chinese Herbal Medicine and Recurrence and Metastasis in Patients with Stages II and III Colorectal Cancer: A Cohort Study in China

Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy

Using advanced convolutional neural network approaches to reveal patient age, gender, and weight based on tongue images

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