Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion

Nacht, Barbara; Larndorfer, Christoph; Sax, Stefan; Borisov, Sergey M.; Hajnsek, Martin; Sinner, Frank; List‐Kratochvil, Emil J. W.; Klimant, Ingo

doi:10.1016/j.bios.2014.08.012

Cited by 39 publications

(40 citation statements)

References 51 publications

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“…The linearity in the range of 0.1–6 mM is relatively good, but the linearity is not satisfactory for the concentration below 0.1 mM, so the limit of detection (LOD) in this study is around 0.1mM. The achieved LOD was comparable to those of reported works as listed in Table 1 [ 4 , 10 , 14 , 18 , 19 , 20 , 32 ]. Although our LOD do not reach the state of the art, this method is much simpler and cheaper.…”

Section: Resultssupporting

confidence: 68%

“…Diabetes results from insulin deficiency, which can increase the levels of glucose in blood [ 6 ], those who are affected by this disease have fasting blood glucose concentrations exceeding the physiological values of 3.9–6.2 mM or postprandial blood glucose levels of 3.9–7.8 mM [ 7 ], which signifies the importance of blood glucose detection for diagnostics. Among the numerous methods (e.g., fluorescence [ 8 , 9 ], colorimetric [ 4 ], near-infrared [ 10 ], and electrochemical [ 2 , 11 , 12 , 13 , 14 ]) developed for measuring blood glucose concentrations, electrochemical sensing is viewed as one of the most successful techniques, which relies on the use of glucose oxidase or glucose oxidase/glucose dehydrogenase to generate hydrogen peroxide [ 15 , 16 ]. However, enzymes are generally unstable and highly environmentally sensitive, additionally featuring the drawbacks of easy biological activity loss and high cost [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and Characterization of a Highly-Sensitive Surface-Enhanced Raman Scattering Nanosensor for Detecting Glucose in Urine

Zhou²,

You³

et al. 2018

Nanomaterials

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Herein we utilized coordination interactions to prepare a novel core-shell plasmonic nanosensor for the detection of glucose. Specifically, Au nanoparticles (NPs) were strongly linked with Ag+ ions to form a sacrificial Ag shell by using 4-aminothiophenol (4-PATP) as a mediator, which served as an internal standard to decrease the influence of the surrounding on the detection. The resultant Au-PATP-Ag core-shell systems were characterized by UV-vis spectroscopy, transmission electron microscopy, and surface-enhanced Raman scattering (SERS) techniques. Experiments performed with R6G (rhodamine 6G) and CV (crystal violet) as Raman reporters demonstrated that the Au@Ag nanostructure amplified SERS signals obviously. Subsequently, the Au@Ag NPs were decorated with 4-mercaptophenylboronic acid (4-MPBA) to specifically recognize glucose by esterification, and a detection limit as low as 10−4 M was achieved. Notably, an enhanced linearity for the quantitative detection of glucose (R2 = 0.995) was obtained after the normalization of the spectral peaks using 4-PATP as the internal standard. Finally, the practical applicability of the developed sensing platform was demonstrated by the detection of glucose in urine with acceptable specificity.

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Section: Resultssupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of a Highly-Sensitive Surface-Enhanced Raman Scattering Nanosensor for Detecting Glucose in Urine

Zhou²,

You³

et al. 2018

Nanomaterials

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show abstract

“…Recent years have seen a great interest in new dyes which show thermally activated delayed fluorescence (TADF)1–4 or phosphorescence,5–8 at room temperature primarily due to their high potential as emitters in OLEDs 6,7,9–11. Phosphorescent dyes have also been applied in various materials for optical sensing12,13 (for example of oxygen,14,15 glucose,16 pH17 or temperature18) and for bioimaging 19–21. They also act as efficient sensitizers in triplet–triplet annihilation (TTA) based upconversion systems 22–24.…”

Section: Introductionmentioning

confidence: 99%

New red-emitting Schiff base chelates: promising dyes for sensing and imaging of temperature and oxygen via phosphorescence decay time

et al. 2018

Self Cite

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“…In a study conducted under hospital settings, the glucose sensing accuracy of the single-port device was evaluated in type 1 diabetes subjects without however administering any insulin via the device [29]. In other in vivo studies, the glucose sensing accuracy of the single-port devices was assessed in anesthetized swine during either constant basal insulin delivery [15], [34], [35] or following the administration of bolus insulin [28], [34]. The MARD values reported in these studies ranged from 13.5% to 22.5% [15], [28], [29].…”

Section: Discussionmentioning

confidence: 99%

Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use

Tschaikner

Powell

Jungklaus

et al. 2020

IEEE Trans. Biomed. Eng.

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Diabetes patients are increasingly using a continuous glucose sensor to monitor blood glucose and an insulin pump connected to an infusion cannula to administer insulin. Applying these devices requires two separate insertion sites, one for the sensor and one for the cannula. Integrating sensor with cannula to perform glucose sensing and insulin infusion through a single insertion site would significantly simplify and improve diabetes treatment by reducing the overall system size and the number of necessary needle pricks. Presently, several research groups are pursuing the development of combined glucose sensing and insulin infusion devices, termed single-port devices, by integrating sensing and infusion technologies created from scratch. Methods: Instead of creating the device from scratch, we utilized already existing technologies and introduced three design concepts of integrating commercial glucose sensors and infusion cannulas. We prototyped and evaluated each concept according to design simplicity, ease of insertion, and sensing accuracy. Results: We found that the best single-port device is the one in which a Dexcom sensor is housed inside a Medtronic cannula so that its glucose sensitive part protrudes from the cannula tip. The low degree of component modification required to arrive at this configuration allowed us to test the efficiency and safety of the device in humans. Conclusion: Results from these studies indicate the feasibility of combining commercial glucose sensing and insulin delivery technologies to realize a functional single-port device. Significance: Our development approach may be generally useful to provide patients with innovative medical devices faster and at reduced costs.

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Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion

Cited by 39 publications

References 51 publications

Fabrication and Characterization of a Highly-Sensitive Surface-Enhanced Raman Scattering Nanosensor for Detecting Glucose in Urine

Fabrication and Characterization of a Highly-Sensitive Surface-Enhanced Raman Scattering Nanosensor for Detecting Glucose in Urine

New red-emitting Schiff base chelates: promising dyes for sensing and imaging of temperature and oxygen via phosphorescence decay time

Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use

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