Integrated approach of nutritional and molecular epidemiology, mineralogical and chemical pollutant characterisation: the protocol of a cross-sectional study in women

Barchitta, Martina; Quattrocchi, Annalisa; Maugeri, Andrea; Barone, Germana; Mazzoleni, Paolo; Catalfo, Alfio; Guidi, Guido De; Iemmolo, Maria; Crimi, Nunzio; Agodi, Antonella

doi:10.1136/bmjopen-2016-014756

Cited by 8 publications

(5 citation statements)

References 41 publications

(63 reference statements)

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“…In Italy, a research group coordinated by Agodi showed poor adherence to the Mediterranean Diet especially in women of childbearing age [ 55 , 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

A Combined Multidisciplinary Intervention for Health Promotion in the Workplace: A Pilot Study

Rapisarda

Cannizzaro

Barchitta

et al. 2021

JCM

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The aim of this study was to assess the effects of a joint health promotion intervention on a cohort of healthcare workers (HCWs) who had at least one cardiovascular risk factor. The HCWs were assessed at three different times, i.e., time zero (T0), after 6 months (T6), and after 12 months (T12). The following parameters were measured at a medical examination: physical activity, blood pressure, waist circumference, body mass index (BMI), routine laboratory tests, plicometric analysis, work ability index (WAI), and body image dissatisfaction (BID). Among the 447 HCWs, 38 HCWs were included in the study; 45% (n = 17) were male. At T12, the average blood pressure, waist/hip ratio (WHR) index, BMI, total cholesterol, triglyceride level, and blood glucose values were reduced. The levels of physical activity and adherence to the Mediterranean diet had progressively increased. The WAI showed a significant shift from low to good work performance at T12, as well as BID score. This is the first study that has analyzed work performance in relation to a workplace health promotion through a multidisciplinary approach. This health promotion intervention that combined diet and sport activity has led to a significant change in HCWs’ lifestyles and body perceptions, as well as their ability to work. This project highlights the importance of using a multidisciplinary approach and the workplace setting in health promotion programs.

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“…In Italy, a research group coordinated by Agodi showed poor adherence to the Mediterranean Diet especially in women of childbearing age [ 55 , 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

A Combined Multidisciplinary Intervention for Health Promotion in the Workplace: A Pilot Study

Rapisarda

Cannizzaro

Barchitta

et al. 2021

JCM

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“…The questions that need to be addressed include the interactive effects of both factors on surrogate molecular markers of diseases. Given this scenario, we recently designed the present project, aiming to evaluate whether adherence to MD, as well as the intake of specific nutrients, might modulate the association between air pollution and methylation in healthy women living in Catania ( Barchitta et al, 2017b ). In previous studies, we demonstrated the effect of both diet and epigenetic mechanisms in several female physiological and pathological conditions ( Agodi et al, 2014 , 2015a , b ; Barchitta et al, 2014a , 2017a , c , 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet and Particulate Matter Exposure Are Associated With LINE-1 Methylation: Results From a Cross-Sectional Study in Women

et al. 2018

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Emerging evidence suggests that air pollution increases the risk of cardiovascular disease (CVD) and metabolic disorders, adding to the global burden of disease attributable to lifestyle and behavioral factors. Although long interspersed nucleotide elements 1 (LINE-1) methylation has been associated with these disorders, no studies have simultaneously examined the effects of diet and air pollution exposure on DNA methylation. Herein, we evaluated the association of particulate matter (PM with aerodynamic diameters of less than 10 mm) exposure and adherence to Mediterranean Diet (MD) with LINE-1 methylation. Healthy women (n = 299), aged 15 to 80 years, were enrolled in a cross-sectional study. Dietary data and adherence to MD were assessed by a Food Frequency Questionnaire (FFQ) and Mediterranean Diet Score (MDS). PM10 levels during 1-month before recruitment were recorded by monitoring stations and assigned to each woman based on their residential address and day of recruitment. LINE-1 methylation in blood samples was assessed by pyrosequencing and reported as percentage of 5-methylcytosine (5mC). The Mann–Whitney U test, Spearman’s rank correlation test and linear regression models were applied. Our results demonstrated, for the first time, an inverse association between adherence to MD and exposure to PM10 with LINE-1 methylation: while higher monthly PM10 exposure decreases LINE-1 methylation level (β = −0.121; p = 0.037), the adherence to MD increases it (β = 0.691; p < 0.001). MDS seemed to interact with PM10 levels (p = 0.002) on LINE-1 methylation, as such we confirmed that the effect of MD decreased with increasing PM10 levels (β = 0.657; p < 0.001 in the first tertile; β = 0.573; p < 0.001 in the second tertile; β = 0.551; p < 0.001 in the third tertile). Thus, we suggest that LINE-1 methylation is a possible mechanism underpinning environment-related health effects, and encourage further research to evaluate whether the adherence to the MD could counteract the negative effect of PM10 exposure.

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“…It is well established that environmentally related diseases are the result of the “exposome”—the totality of exposure experienced by an individual during life and the health impact of those exposures [ 95 ]. Epigenetic phenomena can potentially be modified by environmental and lifestyle factors, including diet, and result in environmental reprogramming of the genome for exposed individuals and future generations of offspring [ 96 ]. For example, altered expression of miRNA profiles in maternal blood or placental tissue may reflect not only gestational disorders but also prenatal exposure to environmental pollutants and dietary factors [ 97 ].…”

Section: Development and Perspectives For Italian Public Health Gementioning

confidence: 99%

Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health

Traversi¹,

Pulliero

Izzotti

et al. 2021

JPM

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The development of high-throughput omics technologies represents an unmissable opportunity for evidence-based prevention of adverse effects on human health. However, the applicability and access to multi-omics tests are limited. In Italy, this is due to the rapid increase of knowledge and the high levels of skill and economic investment initially necessary. The fields of human genetics and public health have highlighted the relevance of an implementation strategy at a national level in Italy, including integration in sanitary regulations and governance instruments. In this review, the emerging field of public health genomics is discussed, including the polygenic scores approach, epigenetic modulation, nutrigenomics, and microbiomes implications. Moreover, the Italian state of implementation is presented. The omics sciences have important implications for the prevention of both communicable and noncommunicable diseases, especially because they can be used to assess the health status during the whole course of life. An effective population health gain is possible if omics tools are implemented for each person after a preliminary assessment of effectiveness in the medium to long term.

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Integrated approach of nutritional and molecular epidemiology, mineralogical and chemical pollutant characterisation: the protocol of a cross-sectional study in women

Cited by 8 publications

References 41 publications

A Combined Multidisciplinary Intervention for Health Promotion in the Workplace: A Pilot Study

A Combined Multidisciplinary Intervention for Health Promotion in the Workplace: A Pilot Study

Mediterranean Diet and Particulate Matter Exposure Are Associated With LINE-1 Methylation: Results From a Cross-Sectional Study in Women

Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health

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