Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis
Fengxia Bai,
Longchao Han,
Jifeng Yang
et al.
Abstract:PurposeThe pathogenesis of renal fibrosis (RF) involves intricate interactions between profibrotic processes and immune responses. This study aimed to explore the potential involvement of the pyroptosis signaling pathway in immune microenvironment regulation within the context of RF. Through comprehensive bioinformatics analysis and experimental validation, we investigated the influence of pyroptosis on the immune landscape in RF.MethodsWe obtained RNA-seq datasets from Gene Expression Omnibus (GEO) databases … Show more
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