Integrated analysis of mRNA and microRNA transcriptome related to immunity and autophagy in shrimp hemocytes infected with Spiroplasma eriocheiris

Ou, Jiangtao; Li, Qiao; Bian, Yunxia; Luan, Xiaoqi; Meng, Yusuo; Dong, Huizi; Cao, Miao; Zhang, Benhou; Zhao, Wei

doi:10.1016/j.fsi.2022.09.035

Cited by 3 publications

(4 citation statements)

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“…Recently, many studies have revealed through transcriptomic analysis that various miRNAs are significantly expressed in aquatic organisms in response to infectious diseases. [30][31][32][33][34]. For example, miRNAs regulations have been revealed in pathogenic protozoan parasites Ectoparasitic dinoflagellate Amyloodinium ocellatum infected golden pompano (Trachinotus ovatus) [30].…”

Section: Microrna Regulation In Aquaculture Responses To Infectious D...mentioning

confidence: 99%

“…Interestingly, Ou et al (2022) investigated the immunity and autophagy in Macrobrachium nipponense shrimp hemocytes infected with Spiroplasma eriocheiris bacteria through integrated analysis of mRNA and miRNA transcriptomes [13]. They found that 25 miRNAs were involved in Toll and IMD pathways, 41 in endocytosis, 30 in the lysosome, and 12 in the vascular endothelial growth factor (VEGF) pathway.…”

Section: Toll and Imd Pathwaysmentioning

confidence: 99%

“…Toll and IMD pathways are initiated when the PAMPs of pathogens are recognized by specific PRRs and further activate a cascade that could induce antimicrobial peptides (AMPs) to regulate innate immunity. In the study of Ou et al (2022), serine protease 4 was found to be regulated by the newly discovered miRNA called PC-5p-707_5272 [33]. In the Toll signalling pathway, recognition of PAMPs by PRRs leads to the activation of the serine protease cascade, which could cause the transformation of prophenoloxidase into phenoloxidase that acts as an enzyme to catalyse melanin production [40].…”

Section: Toll and Imd Pathwaysmentioning

confidence: 99%

“…On the other hand, there are 12 miRNAs revealed in the miRNA transcriptomic study by Ou et al (2022) [33]. For example, putative leupaxin isoform X1 was regulated by dpu-miR-317_R-2; PC-5p-1243_3142 miRNAs and paxillin-like transcripts were regulated by dpu-miR-8_R-1; PC-5p-1243_3142 miRNAs.…”

Section: Vascular Endothelial Growth Factor (Vegf) Pathwaymentioning

confidence: 99%

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MicroRNA Regulation in Infectious Diseases and Its Potential as a Biosensor in Future Aquaculture Industry: A Review

SiouNing,

Seong,

Kondo

et al. 2023

Molecules

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An infectious disease is the most apprehensive problem in aquaculture as it can lead to high mortality in aquatic organisms and massive economic loss. Even though significant progress has been accomplished in therapeutic, prevention, and diagnostic using several potential technologies, more robust inventions and breakthroughs should be achieved to control the spread of infectious diseases. MicroRNA (miRNA) is an endogenous small non-coding RNA that post-transcriptionally regulates the protein-coding genes. It involves various biological regulatory mechanisms in organisms such as cell differentiation, proliferation, immune responses, development, apoptosis, and others. Furthermore, an miRNA also acts as a mediator to either regulate host responses or enhance the replication of diseases during infection. Therefore, the emergence of miRNAs could be potential candidates for the establishment of diagnostic tools for numerous infectious diseases. Interestingly, studies have revealed that miRNAs can be used as biomarkers and biosensors to detect diseases, and can also be used to design vaccines to attenuate pathogens. This review provides an overview of miRNA biogenesis and specifically focuses on its regulation during infection in aquatic organisms, especially on the host immune responses and how miRNAs enhance the replication of pathogens in the organism. In addition to that, we explored the potential applications, including diagnostic methods and treatments, that can be employed in the aquaculture industry.

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