Integrated analysis of expression profiles with meat quality traits in cattle

Li, Yunxiao; Yang, Miaosen; Lou, Angang; Yun, Jinyan; Ren, Cheng; Li, Xiangchun; Xia, Guangjun; Nam, Ki-Chang; Yoon, Duhak; Jin, Haiguo; Seo, Kangseok; Jin, Xin

doi:10.1038/s41598-022-09998-w

Cited by 5 publications

(5 citation statements)

References 104 publications

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“…Increased expression of PCK1 has also been reported in castrated chickens, steer, and prostate cancer patients treated with androgen depletion [33,34]. The expression of Thsrp is also known to increase after castration in chickens and cattle [25,26]. Thsrp is associated with fat accumulation and glucose tolerance, and mice lacking Thsrp show decreased BW [35].…”

Section: Discussionmentioning

confidence: 94%

“…Expression of thyroid hormone-inducible hepatic protein (Thsrp) was also up-regulated in castrated newts (Table 2). Other studies have shown that Thsrp expression is also up-regulated in chickens and cattle after castration [25,26]. None of these groups of up-or down-regulated genes are known to be directly regulated by nuclear androgen receptor (Tables 2 and 3).…”

Section: Liver Transcriptome Analysis To Examine the Effect Of Castra...mentioning

confidence: 95%

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Amphibian newts as experimental models for studying weight gain after castration

Takehara,

Kyakuno,

Okamoto

et al. 2024

Endocr J

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Vertebrate animals often exhibit sexual dimorphism in body shape. In mammals, decreases in sex hormones caused by testicular castration can affect body shape and occasionally lead to pathologies such as obesity. Post-castration obesity can also be problematic for the health of companion animals, including non-mammals. In order to understand the mechanism of post-castration obesity in vertebrates other than mammals, experimental models are required. We examined whether the Iberian ribbed newt, which has recently become a popular experimental model for amphibian research, could serve as a model for analyzing changes in body shape after castration. In newts, new testes can be regenerated after removal of differentiated testes. We analyzed changes in body shape by removing the testes under conditions in which they could regenerate or conditions in which they could not regenerate. Removal of the testes reduced blood testosterone levels. The body weight and abdominal girth of the newts were increased compared with normal male newts. Transcriptome analysis of the liver showed that a set of genes related to lipid metabolism was continuously up-regulated in castrated newts. Our study suggests that changes in body shape after castration are common in vertebrates. Iberian ribbed newts are thus a suitable model for comparative studies of the long-term physiologic-and endocrine-level effects of castration.

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Section: Discussionmentioning

confidence: 94%

Section: Liver Transcriptome Analysis To Examine the Effect Of Castra...mentioning

confidence: 95%

Amphibian newts as experimental models for studying weight gain after castration

Takehara,

Kyakuno,

Okamoto

et al. 2024

Endocr J

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“…Based on the variations in meat quality attributes and 90 differently expressed mRNAs, an integrated study of miRNA and mRNA expression profiling was carried out between bulls and steers, and 18 DE miRNAs were discovered. The findings offered compelling proof of the molecular genetic regulation and gene interactions in cattle [ 46 ].…”

Section: The Role Of Mirnas In Ruminantsmentioning

confidence: 99%

MicroRNAs in Ruminants and Their Potential Role in Nutrition and Physiology

Ojo

Kreuzer-Redmer

2023

Veterinary Sciences

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The knowledge of how diet choices, dietary supplements, and feed intake influence molecular mechanisms in ruminant nutrition and physiology to maintain ruminant health, is essential to attain. In the present review, we focus on the role of microRNAs in ruminant health and disease; additionally, we discuss the potential of circulating microRNAs as biomarkers of disease in ruminants and the state of technology for their detection, also considering the major difficulties in the transition of biomarker development from bench to clinical practice. MicroRNAs are an inexhaustible class of endogenous non-protein coding small RNAs of 18 to 25 nucleotides that target either the 3′ untranslated (UTR) or coding region of genes, ensuring a tight post-transcriptionally controlled regulation of gene expression. The development of new “omics” technologies facilitated a fresh perspective on the nutrition–to–gene relationship, incorporating more extensive data from molecular genetics, animal nutrition, and veterinary sciences. MicroRNAs might serve as important regulators of metabolic processes and may present the inter-phase between nutrition and gene regulation, controlled by the diet. The development of biomarkers holds the potential to revolutionize veterinary practice through faster disease detection, more accurate ruminant health monitoring, enhanced welfare, and increased productivity. Finally, we summarize the latest findings on how microRNAs function as biomarkers, how technological paradigms are reshaping this field of research, and how platforms are being used to identify novel biomarkers. Numerous studies have demonstrated a connection between circulating microRNAs and ruminant diseases such as mastitis, tuberculosis, foot-and-mouth disease, fasciolosis, and metabolic disorders. Therefore, the identification and analysis of a small number of microRNAs can provide crucial information about the stage of a disease, etiology, and prognosis.

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“…colouration; Hubbard et al, 2015), or traits related to nutrition, which is a major focus in agricultural or aquaculture systems (e.g. meat quality; Li et al, 2022). Note that species on which substantial genetic information exists typically lack comparatively substantial ecological information (e.g.…”

Section: Using the Seed Framework To Guide Future Researchmentioning

confidence: 99%

SEED: A framework for integrating ecological stoichiometry and eco‐evolutionary dynamics

El‐Sabaawi,

Lemmen,

Jeyasingh

et al. 2023

Ecology Letters

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Characterising the extent and sources of intraspecific variation and their ecological consequences is a central challenge in the study of eco‐evolutionary dynamics. Ecological stoichiometry, which uses elemental variation of organisms and their environment to understand ecosystem patterns and processes, can be a powerful framework for characterising eco‐evolutionary dynamics. However, the current emphasis on the relative content of elements in the body (i.e. organismal stoichiometry) has constrained its application. Intraspecific variation in the rates at which elements are acquired, assimilated, allocated or lost is often greater than the variation in organismal stoichiometry. There is much to gain from studying these traits together as components of an ‘elemental phenotype’. Furthermore, each of these traits can have distinct ecological effects that are underappreciated in the current literature. We propose a conceptual framework that explores how microevolutionary change in the elemental phenotype occurs, how its components interact with each other and with other traits, and how its changes can affect a wide range of ecological processes. We demonstrate how the framework can be used to generate novel hypotheses and outline pathways for future research that enhance our ability to explain, analyse and predict eco‐evolutionary dynamics.

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Integrated analysis of expression profiles with meat quality traits in cattle

Cited by 5 publications

References 104 publications

Amphibian newts as experimental models for studying weight gain after castration

Amphibian newts as experimental models for studying weight gain after castration

MicroRNAs in Ruminants and Their Potential Role in Nutrition and Physiology

SEED: A framework for integrating ecological stoichiometry and eco‐evolutionary dynamics

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