Integrated analysis of antimicrobial, antioxidant, and phytochemical properties of Cinnamomum verum: A comprehensive In vitro and In silico study

Al-Mijalli, Samiah Hamad; Mrabti, Hanae Naceiri; El Hachlafi, Naoufal; El Kamili, Taha; Elbouzidi, Amine; Abdallah, Emad M.; Flouchi, Rachid; Assaggaf, Hamza; Qasem, Ahmed; Zengin, Gokhan; Bouyahya, Abdelhakim; Chahdi, Fouad Ouazzani

doi:10.1016/j.bse.2023.104700

Cited by 18 publications

(11 citation statements)

References 91 publications

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“…This reinforces the assertion proposing that ecological, climatic, and nutritional conditions quantitatively and qualitatively affect EO components in plants. Several studies have clarified the positive connection between variations in external and internal factors of plants, including climate, seasonal variation, soil composition, metabolic pathways, and the chemical constituents of EOs 10 , 42 .…”

Section: Resultsmentioning

confidence: 99%

“…EOs with the highest antiradical ability may play a pivotal role in diseases prevention, such as neurodegenerative pathologies, cancer, inflammatory disease, and immune system decline 10 . They could protect cell from the harmful effects generated by free radicals, thus preserving proper physiological function 13 , 49 .…”

Section: Resultsmentioning

confidence: 99%

“…2,2′-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging method was performed as indicated by Al-Mijalli et al 10 , with minor modifications. Briefly, the cationic ABTS radical was produced by reacting 10 mL of the solution of ABTS (2 mM) with 0.1 mL of potassium persulfate solution (70 mM).…”

Section: Materiel and Methodsmentioning

confidence: 99%

“…In fact, researchers have recently turned their attention to new preservatives, such as the development of new and non-toxic antioxidant formulations from natural resources, especially essential oils (EOs). EOs are defined as multifaceted bioactive components that comprise various classes of chemical compounds, including monoterpenes, alcohols, sesquiterpenes, aldehydes, phenols, esters, ethers, ketones 10 – 13 . They possess important antioxidant properties and are found applications as natural antioxidants in the food industry and pharmacy 14 – 16 .…”

Section: Introductionmentioning

confidence: 99%

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Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity

Assaggaf,

Jeddi,

Mrabti

et al. 2024

Sci Rep

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The development of novel antioxidant compounds with high efficacy and low toxicity is of utmost importance in the medicine and food industries. Moreover, with increasing concerns about the safety of synthetic components, scientists are beginning to search for natural sources of antioxidants, especially essential oils (EOs). The combination of EOs may produce a higher scavenging profile than a single oil due to better chemical diversity in the mixture. Therefore, this exploratory study aims to assess the antioxidant activity of three EOs extracted from Cymbopogon flexuosus, Carum carvi, and Acorus calamus in individual and combined forms using the augmented-simplex design methodology. The in vitro antioxidant assays were performed using DPPH and ABTS radical scavenging approaches. The results of the Chromatography Gas-Mass spectrometry (CG-MS) characterization showed that citral (29.62%) and niral (27.32%) are the main components for C. flexuosus, while d-carvone (62.09%) and d-limonene (29.58%) are the most dominant substances in C. carvi. By contrast, β-asarone (69.11%) was identified as the principal component of A. calamus (30.2%). The individual EO exhibits variable scavenging activities against ABTS and DPPH radicals. These effects were enhanced through the mixture of the three EOs. The optimal antioxidant formulation consisted of 20% C. flexuosus, 53% C. carvi, and 27% A. calamus for DPPHIC50. Whereas 17% C. flexuosus, 43% C. carvi, and 40% A. calamus is the best combination leading to the highest scavenging activity against ABTS radical. These findings suggest a new research avenue for EOs combinations to be developed as novel natural formulations useful in food and biopharmaceutical products.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Materiel and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity

Assaggaf,

Jeddi,

Mrabti

et al. 2024

Sci Rep

Self Cite

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“…Aromatic and medicinal plants (AMPs) have caught the attention of researchers due to their rich bioactive compound content, making them valuable for drug development and natural product exploration ( Al-Mijalli et al, 2023 ). Essential oils (EOs) are particularly noteworthy among these compounds due to their chemical diversity and wide range of biological effects.…”

Section: Introductionmentioning

confidence: 99%

Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities

Haddou,

Elbouzidi,

Taibi

et al. 2024

Front. Chem.

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Introduction: This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments.Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus niger, Penicillium digitatum) strains. Antidiabetic and anti-gout potential were investigated through α-amylase, α-glucosidase, and xanthine oxidase inhibition assays. Antityrosinase activity was determined using a modified dopachrome method. Cytotoxicity was assessed by MTT assay against breast (MCF-7, MDA-MB-468), liver (HepG2), colon (HCT-15) cancer cells, and normal cells (PBMCs).Results and discussion: LPEO exhibits potent antiradical activity (IC50 = 148.33 ± 2.48 μg/mL) and significant antioxidant capacity (TAC = 171.56 ± 2.34 μg AA/mg of EO). It demonstrates notable antibacterial activity against four strains (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, and Pseudomonas aeruginosa) with inhibition zones ranging from 18.70 ± 0.30 mm to 29.20 ± 0.30 mm, along with relatively low MIC and MBC values. LPEO displays significant antifungal activity against four strains (Candida glabrata, Rhodotorula glutinis, Aspergillus niger, and Penicillium digitatum) with a fungicidal effect at 1 mg/mL, surpassing the positive control (cycloheximide), and MIC and MFC values indicating a fungicidal effect. It exhibits substantial inhibition of xanthine oxidase enzyme (IC50 = 26.48 ± 0.90 μg/mL), comparable to allopurinol, and marked inhibitory effects on α-amylase (IC50 = 31.56 ± 0.46 μg/mL) and α-glucosidase (IC50 = 58.47 ± 2.35 μg/mL) enzymes.The enzyme tyrosinase is inhibited by LPEO (IC50 = 29.11 ± 0.08 mg/mL). LPEO displays moderate cytotoxic activity against breast, liver, and colon cancer cells, with low toxicity towards normal cells (PBMC). LPEO exhibits greater selectivity than cisplatin for breast (MCF-7) and colon (HCT-15) cancer cells but lower selectivity for liver (HepG2) and metastatic breast (MDA-MB-468) cancer cells. These findings suggest the potential of LPEO as an antioxidant, antimicrobial, anti-gout, antidiabetic, and anticancer agent.

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Unveiling the phytochemical profile, in vitro bioactivities evaluation, in silico molecular docking and ADMET study of essential oil from Clinopodium nepeta grown in Middle Atlas of Morocco

Benkhaira,

El Hachlafi,

El fadili

et al. 2023

Biocatalysis and Agricultural Biotechnology

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Integrated analysis of antimicrobial, antioxidant, and phytochemical properties of Cinnamomum verum: A comprehensive In vitro and In silico study

Cited by 18 publications

References 91 publications

Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity

Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity

Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities

Unveiling the phytochemical profile, in vitro bioactivities evaluation, in silico molecular docking and ADMET study of essential oil from Clinopodium nepeta grown in Middle Atlas of Morocco

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