Integrated analyses reveal the diagnostic and predictive values of COL5A2 and association with immune environment in Crohn’s disease
Tingting Zhong,
Xiaoqing Cheng,
Qianru Gu
et al.
Abstract:The pathogenesis of Crohn’s disease (CD) involves abnormal immune cell infiltration and dysregulated immune response. Therefore, thorough research on immune cell abnormalities in CD is crucial for improved treatment of this disease. Single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data of CD were obtained from the Gene Expression Omnibus (GEO) database. Cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT), weighted gene co-expression network analysis (WGCNA), protein–pr… Show more
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