We develop a formalism of poly-vector deformations for Type IIB backgrounds with a block diagonal metric and non-vanishing self-dual 5-form RR field strength. Making use of the embedding of the Type IIB theory into the $$\textrm{E}_{6(6)}$$
E
6
(
6
)
exceptional field theory we derive explicit transformation rules for four-vector deformations. We prove that the algebraic condition following from the Type IIB realization of exceptional Drinfeld algebras is sufficient for the transformation to generate a solution.