Intake of specific flavonoids and risk of acute myocardial infarction in Italy

Tavani, Alessandra; Spertini, Luana; Bosetti, Cristina; Parpinel, Maria; Gnagnarella, Patrizia; Bravi, Francesca; Peterson, Julie; Dwyer, Johanna T.; Λάγιου, Παγώνα; Negri, Eva; Vecchia, Carlo La

doi:10.1079/phn2006859

Cited by 47 publications

(38 citation statements)

References 32 publications

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“…Also, extract II had a more noticeable effect than extract I, particularly in MDA-MB-231 cells. (Rossi et al, 2006;Tavani et al, 2006). These compounds have been widely studied for their biological properties, namely antioxidant, anti-bacterial, antiinflammatory, anti-cancer among others (Gerhauser, 2008;Heinonen, 2007;Wang and Stoner, 2008).…”

Section: Resultsmentioning

confidence: 99%

Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines

Faria

Pestana

Teixeira

et al. 2010

Phytotherapy Research

117

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The purpose of this study was to investigate the anti-cancer properties of an anthocyanin-pyruvic acid adduct extract, which is being developed aiming to be further applied in the food industry. An anthocyanin extract from blueberry (extract I) and an anthocyanin-pyruvic acid adduct extract (extract II) were tested on two breast cancer cell lines (MDA-MB-231 and MCF7). Proliferation was assessed by SRB assay and 3 Hthymidine incorporation. Caspase-3 activity was determined in the presence of both extracts. Their capacity as chemoattractant and their invasive potential were also assayed.In both cell lines, extracts I and II significantly reduced cell proliferation at 250 µg/ml, after 24h of cell incubation. Caspase-3 activity was not altered by the extracts (250µg/ml) in both cell lines, with exception for extract II in MCF-7, which increased its activity, probably explaining its effects on cell proliferation.Both extracts (250 µg/ml) demonstrated significant anti-invasive potential in both cell lines. Furthermore, they did not demonstrate any capacity for chemotaxis.In conclusion, blueberry anthocyanins and respective anthocyanin-pyruvic acid adducts demonstrated anti-cancer properties by inhibiting cancer cell proliferation and by acting as cell anti-invasive factors and chemoinhibitors. Anthocyanin-pyruvic acid adduct extract showed a more pronounced effect in MDA-MB-231, suggesting an effect independent of estrogen receptors.

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Section: Resultsmentioning

confidence: 99%

Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines

Faria

Pestana

Teixeira

et al. 2010

Phytotherapy Research

117

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“…Subjects investigated were 3247 adults (1969 women and 1278 men, median age 59 years, age range 18-80 years), from the comparison group of a network of case-control studies on cancer and myocardial infarction collected in the greater Milan area, northern Italy, between 1991(Galeone et al, 2006Tavani et al, 2006). These subjects were admitted to a network of hospitals in the area under surveillance for a wide spectrum of acute conditions, unrelated to known risk factors for cancer and myocardial infarction, and to longterm modifications of diet.…”

Section: Methodsmentioning

confidence: 99%

Trends in adherence to the Mediterranean diet in an Italian population between 1991 and 2006

et al. 2010

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Background/Objectives: The aim of this study is to investigate whether adherence to the Mediterranean diet changed during the period [1991][1992][1993][1994][1995][1996][1997][1998][1999][2000][2001][2002][2003][2004][2005][2006] in an Italian population. Subjects/Methods: We derived data from the comparison groups of a network of case-control studies on cancer and acute myocardial infarction conducted in the greater Milan area between 1991 and 2006. Subjects were 3247 adults (1969 women, 1278 men; median age 59 years) admitted to major teaching and general hospitals for a wide spectrum of acute conditions unrelated to long-term modifications of diet. Trained interviewers collected data on selected socioeconomic and demographic characteristics, lifestyle habits and other personal and familial factors. Information on diet was collected through an interviewer-administered, reproducible and validated food-frequency questionnaire. We computed a Mediterranean diet score (MDS) on the basis of nine a priori defined peculiar characteristics of the Mediterranean dietary pattern. Results: In multiple linear regression models, adjusted for age, education, place of birth and residence, and total energy intake, there was no significant association between the period of interview and MDS in both sexes. Subjects aged 55-64 years, those with high education, and those born in central and southern Italy showed the highest adherence to the Mediterranean diet in both sexes. Conclusions: In this population, adherence to the Mediterranean diet showed no significant change over the last 15 years.

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“…Low intakes of vitamin D emerged as the sole predictor for stroke, while high dietary intakes of luteolin and kaempferol were associated with lowered risk of AMI in a statistically significant way (p < 0.01). Mink et al [74] It appears that nutritional uptake of luteolin or its glycosides in very low amounts contributes to protection from cardiovascular disease (but not from stroke); there are, however, also some studies which could not find such a correlation [76], [77]. Besides inflammatory and allergic reactions, cardiovascular disease and cancer, various indications like diabetes mellitus, multiple sclerosis, or leishmaniasis have been discussed as possible therapeutic fields for luteolin.…”

Section: Discussionmentioning

confidence: 99%

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2008

Planta Med

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Intake of specific flavonoids and risk of acute myocardial infarction in Italy

Abstract: High intake of anthocyanidins reduced the risk of AMI even after allowance for alcohol, fruit and vegetables, supporting a real inverse association between this class of flavonoids and AMI risk.

Cited by 47 publications

References 32 publications

Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines

Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines

Trends in adherence to the Mediterranean diet in an Italian population between 1991 and 2006

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