Intake of Soy Products and Other Foods and Gastric Cancer Risk: A Prospective Study

Abstract

BackgroundGastric cancer, the most common cancer in the world, is affected by some foods or food groups. We examined the relationship between dietary intake and stomach cancer risk in the Korean Multi-Center Cancer Cohort (KMCC).MethodsThe KMCC included 19 688 Korean men and women who were enrolled from 1993 to 2004. Of those subjects, 9724 completed a brief 14-food frequency questionnaire at baseline. Through record linkage with the Korean Central Cancer Registry and National Death Certificate databases, we documented 166 gastric cancer cases as of December 31, 2008. Cox proportional hazard models were used to estimate relative risks (RRs) and 95% CIs.ResultsFrequent intake of soybean/tofu was significantly associated with reduced risk of gastric cancer, after adjustment for age, sex, cigarette smoking, body mass index, alcohol consumption, and area of residence (P for trend = 0.036). We found a significant inverse association between soybean/tofu intake and gastric cancer risk among women (RR = 0.41, 95% CI: 0.22–0.78). Men with a high soybean/tofu intake had a lower risk of gastric cancer, but the reduction was not statistically significant (RR = 0.77, 95% CI: 0.52–1.13). There was no interaction between soybean/tofu intake and cigarette smoking in relation to gastric cancer risk (P for interaction = 0.268).ConclusionsFrequent soybean/tofu intake was associated with lower risk of gastric cancer.

Diet and Cancer Risk in the Korean Population: A Meta-analysis

“…Various diets among the Korean population have been studied for the risk of gastric (10 studies) (Kim et al, 2002;Ko et al, 2013;Ko et al, 2009;Lee et al, 1995;Lee et al, 2003a;Nan et al, 2005;Park et al, 1998;Park et al, 2000;Wie et al, 2014;Zhang et al, 2009), colorectal (5 studies) (Ahn et al, 2006;Kim et al, 2011;Kim et al, 2003;Lee et al, 2005;Oh et al, 2005) and breast cancer (10 studies) (Cho et al, 2010;Do et al, 2007;Hong et al, 2008;Kim et al, 2009;Kim et al, 2008;Lee et al, 2007;Lee et al, 2004;Lee et al, 2003b;Shin et al, 2010;Yu et al, 2010) (Tables 1-3); the studied diet types have been mostly soy products, fruits, and vegetables. A limited number of studies were conducted for each diet.…”

“…Thus caution should be made when interpreting the results. c 'soybean products' (Kim et al, 2002;Ko et al, 2009 ), 'soybean/ tofu' (Ko et al, 2013), and 'nonfermented soybean foods' (Zhang et al, 2009) were included.…”

Molecular approaches for genetic improvement of seed quality and characterization of genetic diversity in soybean: a critical review

“…It enhances soil fertility with efficient symbiotic N 2 fixing ability. Further, the crop holds promise due to the possible production of soybean protein-based biodegradable materials (Song et al 2011) and anti-cancerous formulations (Ko et al 2013). Understanding the process of soybean genetic improvement is vital for future gains in breeding improved soybean varieties (Zhou et al 2015).…”

Different Pathophysiology of Gastritis in East and West? A Western Perspective

“…In Korea, a protective effect in females but not males was found [132], and in postmenopausal Chinese women, soy intake was inversely related to plasma levels of IL-6, TNFα and soluble TNF receptors [133]. …”

“…This may explain discordant results in different regions and in genders [131,132,136]. Soy products are used on a daily basis in East Asia.…”