Intake of selected micronutrients and risk of colorectal cancer

Vecchia, Carlo La; Braga, Cláudia; Negri, Eva; Franceschi, Silvia; Russo, Antonio; Conti, Ettore; Falcini, Fabio; Giacosa, Attilio; Montella, M.; Decarli, Adriano

doi:10.1002/(sici)1097-0215(19971114)73:4<525::aid-ijc12>3.0.co;2-8

Cited by 140 publications

(99 citation statements)

References 21 publications

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“…In two large female cohorts including both smokers and non-smokers, the Iowa Women's Health Study and the Nurses' Health Study, no significant association was observed between dietary intake of vitamin E and colorectal cancer risk (Willett et al, 1990;Bostick et al, 1993;Sellers et al, 1998). Case -control studies have yielded conflicting results: either inverse associations (Ferraroni et al, 1994;Ghadirian et al, 1997;La Vecchia et al, 1997) or no association has been observed (Freudenheim et al, 1990;Benito et al, 1991;Peters et al, 1992;Meyer & White, 1993;Olsen et al, 1994;Slattery et al, 1998). The intake level of dietary vitamin E in the present cohort was similar to that reported from other study populations (Peters et al, 1992;Slattery et al, 1998), and the intake level varied sufficiently: there was a 2.5-fold difference in median intake of vitamin E between the first and fourth quartile.…”

Section: Discussioncontrasting

confidence: 52%

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Dietary and serum α-tocopherol, β-carotene and retinol, and risk for colorectal cancer in male smokers

Malila¹,

Virtamo²,

Virtanen³

et al. 2002

Eur J Clin Nutr

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Objective: To study the association between dietary and serum antioxidant vitamins and carotenoids and risk for colorectal cancer in male smokers. Design: A prospective cohort study within a randomised, double-blind, placebo-controlled trial testing supplementation with atocopherol (50 mg=day), b-carotene (20 mg=day) or both in preventing cancer. Subjects and methods: Participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study with complete dietary data and serum samples available from baseline. These included 26 951 middle-aged male smokers among whom 184 colorectal cancer cases were diagnosed during 8 y of follow-up. Relative risks were calculated with Cox proportional hazards models adjusting for trial supplementation, age, body mass index, serum cholesterol, cigarettes smoked per day and physical activity. Results: There was no significant association between dietary vitamin C or E, a-or g-tocopherol, retinol, a-or b-carotene, lycopene or lutein þ zeaxanthin and risk for colorectal cancer. Serum a-tocopherol, b-carotene or retinol was also not associated with the risk, neither did the season when baseline blood was drawn modify the relationship between serum b-carotene and colorectal cancer risk. Conclusions: Our data support the results from previous studies in which no association between dietary antioxidant vitamins and carotenoids and risk for colorectal cancer has been observed. Likewise, no association between baseline serum antioxidant concentrations and colorectal cancer risk was evident.

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Section: Discussioncontrasting

confidence: 52%

“…In about half of the case -control studies, dietary carotenes have been inversely associated with colorectal cancer risk (van Poppel, 1993;Ferraroni et al, 1994;La Vecchia et al, 1997). In such studies, however, carotene intake may have been altered, either due to changes in dietary habits or changes in metabolism caused by the disease.…”

Section: Discussionmentioning

confidence: 99%

Dietary and serum α-tocopherol, β-carotene and retinol, and risk for colorectal cancer in male smokers

Malila¹,

Virtamo²,

Virtanen³

et al. 2002

Eur J Clin Nutr

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“…Briefly, we reviewed 9 articles of vitamin B2 intake and risk of colorectal cancer (La Vecchia et al, 1997;Jedrychowski et al, 2001;Shin et al, 2006;de Vogel et al, 2008;E Ma et al, 2009;Shrubsole et al, 2009;van Lee et al, 2011;Bassett et al, 2013;Zschabitz et al, 2013), published from 1997 to 2013. But we found the article has been published by Shin in 2006 and the article has been published by Shrubsole in 2009 are using the same cohort: The Shanghai Women's Health Study (SWHS).…”

Section: Literature Searchmentioning

confidence: 99%

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Liu¹,

Yu²,

Zhu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (3), 909-913 IntroductionIn 2013, colorectal cancer was newly diagnosed in 73,680 males in the United States; 26,300 died of the disease. It was newly diagnosed in 69,140 females and 24,530 died (Siegel et al., 2013). Indeed, colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, with more than 1.2 million new cases and 608,700 deaths estimated to have occurred in 2008 (Center et al., 2009.Vitamin B2 (chemical formula: C17H20N4O6) also known as riboflavin . In fact, the flavin in riboflavin comes from flavus, the Latin word for yellow. (yellow enzymes play a role of hydrogen in the biological oxidation reduction). Vitamin B2 is one of many nutrients required to recycle glutathione, which is one of the most important antioxidants in the human body. (From a chemical standpoint, what B2 does is facilitate the conversion of oxidized glutathione into reduced glutathione.) (Yasuda and Hiraoka, 1999).Riboflavin is unique among the water-soluble vitamins in that milk and dairy products make the greatest contribution to its intake in Western diets. Meat and fish are also good sources of riboflavin, and certain fruit and vegetables, especially dark-green vegetables, contain reasonably high concentrations (Powers, 2003). Vitamin B2 has limited storage , So it need a food supplement Conclusions: This is the first meta-analysis to study links between vitamin B2 and colorectal cancer. We found vitamin B2 intake was inversely associated with risk of colorectal cancer. However, further research and large sample studies need to be conducted to better validate the result.

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“…11 A multicentric Italian case-control study found RRs of 0.7-0.8 in the highest quintile of folic acid compared to the lowest. 12 Regular alcohol drinking is frequent in the Italian population. 13 We decided, therefore, to further consider the effect of folate consumption in the Italian multicentric study, 12 using a comprehensive food-composition database including more than 60 natural sources of folate.…”

mentioning

confidence: 99%

“…12,15 Cases were 1,225 subjects with histologically confirmed, incident cancer of the colon and 728 with cancer of the rectum, aged 23-74 years (median 62). Controls were patients admitted to the same hospitals for acute, non-neoplastic conditions unrelated to digestive tract diseases.…”

mentioning

confidence: 99%

Dietary folate and colorectal cancer

Vecchia

Negri

Pelucchi

et al. 2002

Intl Journal of Cancer

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Folate may be inversely related to colorectal cancer risk, possibly in combination with low methionine and high alcohol consumption. We considered, therefore, the relation between folate and colorectal cancer in a multicentric casecontrol study of 1,953 cases and 4,154 controls from Italy, i.e., a population with frequent regular alcohol drinking. In the overall data set, the odds ratio (OR) was 0.72 for the highest quintile of folate, and the continuous OR per 100 g was 0.86. The inverse relation was similar in men and women and somewhat stronger for the rectum (OR ‫؍‬ 0.59 for the highest quintile) compared to the colon (OR ‫؍‬ 0.81). It was also somewhat stronger in the highest tertile of alcohol drinking (OR ‫؍‬ 0.65), though trends were not heterogeneous across strata of alcohol, whereas no appreciable difference was observed across strata of methionine intake. Compared to subjects reporting low alcohol, high methionine and high folate intake, the OR was 1.83 for those reporting high alcohol, low methionine and low folate intake. Folate is important for DNA methylation and repair, and abnormalities in DNA methylation may contribute to loss of normal control of proto-oncogene expression. Folate and methionine are involved in the production of S-adenosylmethionine, the primary methyl donor in the body. Alcohol consumption may increase folate requirements and cause relative folate deficiency, 1,2 which has been related to increased breast cancer risk. [3][4][5] Folate deficiency, or simply low levels of folate intake, may be related to the risk of colorectal cancer, possibly together with elevated alcohol drinking. 2,6 -8 Thus, in the American Health Professionals cohort study, based on 205 cases of colon cancer, the relative risk (RR) was 3.3 for the combination of low folate, low methionine and high alcohol intake compared to low alcohol, high methionine, high folate intake among nonusers of aspirin. 2 In a cohort study based on the Canadian National Breast Screening Study, the RR was 0.6 for the highest level of folate intake. 9 A large, multicentric U.S. case-control study 10 found no consistent support for an association between folate, other factors involved in DNA methylation and colon cancer risk; in the NHANES I epidemiologic follow-up study, the RR was 1.6 for subjects reporting low-folate, low-methionine and high-alcohol diets compared to those reporting low-alcohol, high-folate and high-methionine diets. The association was stronger in men. 11 A multicentric Italian case-control study found RRs of 0.7-0.8 in the highest quintile of folic acid compared to the lowest. 12 Regular alcohol drinking is frequent in the Italian population. 13 We decided, therefore, to further consider the effect of folate consumption in the Italian multicentric study, 12 using a comprehensive food-composition database including more than 60 natural sources of folate. 14 We also considered the interaction of folate with alcohol and methionine on the risk of colorectal cancer in Italy.The data were derived from a case-contro...

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Intake of selected micronutrients and risk of colorectal cancer

Cited by 140 publications

References 21 publications

Dietary and serum α-tocopherol, β-carotene and retinol, and risk for colorectal cancer in male smokers

Dietary and serum α-tocopherol, β-carotene and retinol, and risk for colorectal cancer in male smokers

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Dietary folate and colorectal cancer

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