Intake of Plant Based Foods and Colorectal Cancer. A Case-Control Study in Romania

Gavrilaș, Laura Ioana; Ionescu, Clara M.; Bălăcescu, Ovidiu; Muresan, Daniela; Revnic, Cornelia; Filip, Lorena; Miere, Doina

doi:10.15835/buasvmcn-fst:2018.0005

Cited by 5 publications

(5 citation statements)

References 30 publications

(34 reference statements)

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“…Poor eating habits characterized by low dietary diversity and intake of essential nutrients contribute to intestinal dysbiosis [43]. Other factors affecting nutritional status of patients seeking BS are related to chronic diseases [44,45], medication [46], rapid weight loss that is often required before surgery [47], or chronic dieting [48].…”

Section: Micronutrient Status Of Bs Candidates: Impact On Gmmentioning

confidence: 99%

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

et al. 2020

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Obesity is associated with reduced gut microbial diversity and a high rate of micronutrient deficiency. Bariatric surgery, the therapy of choice for severe obesity, produces sustained weight loss and improvements in obesity-related comorbidities. Also, it significantly alters the gut microbiota (GM) composition and function, which might have an important impact on the micronutrient status as GM is able to synthesize certain vitamins, such as riboflavin, folate, B12, or vitamin K2. However, recent data have reported that GM is not fully restored after bariatric surgery; therefore, manipulation of GM through probiotics represents a promising therapeutic approach in bariatric patients. In this review, we discuss the latest evidence concerning the relationship between obesity, GM and micronutrients, the impact of bariatric surgery on GM in relation with micronutrients equilibrium, and the importance of the probiotics’ supplementation in obese patients submitted to surgical treatment.

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Section: Micronutrient Status Of Bs Candidates: Impact On Gmmentioning

confidence: 99%

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

et al. 2020

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“…The human colon cancer HCT116 cell line was also exposed to the present water extract in order to explore eventual antiproliferative effects. In this regard, it is sensitive to highlight the potential efficacy of an adequate intake of fruit as a strategy to prevent the onset of colorectal cancer [ 23 ]. Consistently with the evaluation of extract effects on colon pro-inflammatory biomarkers, we investigated the bacteriostatic properties of P. mahaleb water extract against multiple pathogen bacterial strains, namely Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, which are involved in ulcerative colitis [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf

et al. 2021

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Prunus mahaleb L. fruit has long been used in the production of traditional liqueurs. The fruit also displayed scavenging and reducing activity, in vitro. The present study focused on unravelling peripheral and central protective effects, antimicrobial but also anti-COVID-19 properties exerted by the water extract of P. mahaleb. Anti-inflammatory effects were studied in isolated mouse colons exposed to lipopolysaccharide. Neuroprotection, measured as a blunting effect on hydrogen-peroxide-induced dopamine turnover, was investigated in hypothalamic HypoE22 cells. Antimicrobial effects were tested against different Gram+ and Gram- bacterial strains. Whereas anti-COVID-19 activity was studied in lung adenocarcinoma H1299 cells, where the gene expression of ACE2 and TMPRSS2 was measured after extract treatment. The bacteriostatic effects induced on Gram+ and Gram- strains, together with the inhibition of COX-2, TNFα, HIF1α, and VEGFA in the colon, suggest the potential of P. mahaleb water extract in contrasting the clinical symptoms related to ulcerative colitis. The inhibition of the hydrogen peroxide-induced DOPAC/DA ratio indicates promising neuroprotective effects. Finally, the downregulation of the gene expression of ACE2 and TMPRSS2 in H1299 cells, suggests the potential to inhibit SARS-CoV-2 virus entry in the human host. Overall, the results support the valorization of the local cultivation of P. mahaleb.

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“…Since both obesity and dietary factors are main risk factors for CRC, it is of main importance to explore the relationship between diet and CRC in our population. In this context, we designed a case-control study with the main objective to investigate pre-diagnostic lifestyle habits (physical activity, smoking, dietary habits) of CRC patients in a Romanian sample [5][6][7][8]14]. Our analysis aimed to evaluate the frequency of consumption of different foods and food groups together with culinary techniques and explore the possible dietary risk or protective factors associated with CRC.…”

Section: Introductionmentioning

confidence: 99%

Foods and Food Groups Associated With Colorectal Cancer: A Case-Control Study

Gavrilaș¹

2018

FARMACIA

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Dietary habits act as important determinants of cancer risk and are especially associated with colorectal cancer (CRC), one of the most important diet-related types of cancer. In this regard, the main goal of the present study was to investigate the risk and protective dietary factors related with CRC in Romanian population. A case-control study was conducted from August 2015 until January 2017. Data was collected from cancer-free controls (n = 151) and CRC cases (n = 151) using a food frequency questionnaire. The questionnaire was completed during a face-to-face interview led by a trained dietitian. The results showed that intake of poultry, fish, and fibre-rich foods are inversely associated with CRC risk. Furthermore, dietary habits linked with a Western diet such as high intake of processed meat, sugar-sweetened beverages, white bread and dessert (p = 0.001) were more frequent in the CRC group. RezumatObiceiurile alimentare acționează ca factori determinanți ai riscului de cancer și sunt îndeosebi asociate riscului de cancer colorectal (CCR), unul dintre cele mai importante tipuri de cancer corelate cu regimul alimentar. Obiectivul principal al acestui studiu a fost evaluarea dietei ca factor de risc sau de protecție în cancerul colorectal prin intermediul unui studiu efectuat, efectuat în perioada august 2015 -ianuarie 2017. Au fost incluși 302 participanți distribuiți în grupul experimental (n = 151) și în grupul control (n = 151), iar informațiile legate de dietă au fost obținute prin intermediul unui chestionar, în timpul unui interviu realizat de către un dietetician. Rezultatele au arătat că un consum frecvent de pui, pește și alimente bogate în fibre sunt invers asociate riscului de cancer, în timp ce obiceiurile alimentare caracteristice dietei de tip vestic, precum consumul de carne procesată, dulciuri și sucuri îndulcite au fost mai frecvente în grupul pacienților cu CCR.

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Intake of Plant Based Foods and Colorectal Cancer. A Case-Control Study in Romania

Cited by 5 publications

References 30 publications

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf

Foods and Food Groups Associated With Colorectal Cancer: A Case-Control Study

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