Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery

Farooq, Muhammad; Gærtner, S.; Amoura, Lamia; Niazi, Zahid Rasul; Park, Sin‐Hee; Qureshi, Abdul Wahid; Oak, Min–Ho; Toti, Florence; Schini‐Kerth, Valérie B.; Auger, Cyril

doi:10.1016/j.bcp.2019.113749

Cited by 22 publications

(17 citation statements)

References 56 publications

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“…On the contrary, supplementation with omega-3 fatty acids is reported not only to reduce arterial contraction [ 70 , 71 , 72 , 73 ], but also to improve endothelium-dependent relaxation [ 74 , 75 , 76 , 77 , 78 ]. Our results agree with those of Farooq et al, which show that omega-3 supplementation reverts the impairment of endothelium-dependent relaxation, the increase in angiotensin AT-1 receptor expression and the oxidative stress induced by aging in rat mesenteric arteries [ 79 ]. Thus, the beneficial effects an vascular function are most likely mediated by omega 3 PUFA, although the decrease in SFA may also be involved, since increased levels of SFA are reported to impair endothelium-dependent vasorelaxation in aging [ 80 ].…”

Section: Discussionsupporting

confidence: 93%

“…Indeed, decreased vascular inflammation and oxidative stress may be the mechanism by which the oil mixture treatment attenuates endothelial dysfunction in aged rats, as it significantly reduced the arterial expression of pro-inflammatory enzymes like COX-2 and prooxidant enzymes like NOX-4. Similarly, other authors have reported that both omega-3 and MUFA fatty acids supplementation exerts antioxidant and anti-inflammatory effects in arterial cells or tissue [ 79 , 83 ].…”

Section: Discussionmentioning

confidence: 71%

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A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

et al. 2020

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Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase in life expectancy, there is a strong interest in the search for anti-aging strategies to treat and prevent these aging-induced disorders. Both omega 3 polyunsaturated fatty acids (ω-3 PUFA) and extra virgin olive oil (EVOO) exert numerous metabolic and cardiovascular benefits in the elderly. In addition, EVOO constitutes an interesting ingredient to stabilize ω-3 PUFA and decrease their oxidation process due to its high content in antioxidant compounds. ω-3 PUFA are commonly obtained from fish. However, more ecological and sustainable sources, such as algae oil (AO) can also be used. In this study, we aimed to study the possible beneficial effect of an oil mixture composed by EVOO (75%) and AO (25%) rich in ω-3 PUFA (35% docosahexaenoic acid (DHA) and 20% eicosapentaenoic acid (EPA)) on the cardiometabolic alterations associated with aging. For this purpose; young (three months old) and old (24 months old) male Wistar rats were treated with vehicle or with the oil mixture (2.5 mL/kg) for 21 days. Treatment with the oil mixture prevented the aging-induced increase in the serum levels of saturated fatty acids (SFA) and the aging-induced decrease in the serum concentrations of mono-unsaturated fatty acids (MUFA). Old treated rats showed increased serum concentrations of EPA and DHA and decreased HOMA-IR index and circulating levels of total cholesterol, insulin and IL-6. Treatment with the oil mixture increased the mRNA levels of antioxidant and insulin sensitivity-related enzymes, as well as reduced the gene expression of pro-inflammatory markers in the liver and in cardiac and aortic tissues. In addition, the treatment also prevented the aging-induced endothelial dysfunction and vascular insulin resistance through activation of the PI3K/Akt pathway. Moreover, aortic rings from old rats treated with the oil mixture showed a decreased response to the vasoconstrictor AngII. In conclusion, treatment with a mixture of EVOO and AO improves the lipid profile, insulin sensitivity and vascular function in aged rats and decreases aging-induced inflammation and oxidative stress in the liver, and in the cardiovascular system. Thus, it could be an interesting strategy to deal with cardiometabolic alterations associated with aging.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 71%

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

et al. 2020

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“…The doses used were representative of the nontoxic and effective range of NCM 1921 based on previous reports about individual components of NCM1921 (n-3 PUFA, caprylic, lauric acid, etc.) [18][19][20]. The severity of dermatitis and the clinical index of dermatitis were assessed according to a previously reported method [21].…”

Section: Animal Experimentsmentioning

confidence: 99%

NCM 1921, a Mixture of Several Ingredients, Including Fatty Acids and Choline, Attenuates Atopic Dermatitis in 1-Chloro-2,4-Dinitrobenzene-Treated NC/Nga Mice

Lee

Yang

et al. 2020

Nutrients

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Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. In this study, we evaluated the effects of a mixture (NCM 1921) of omega-3 butter, omega-3 beef tallow oil, omega-3 lard oil, caprylic acid, lauric acid, choline, and Fe on AD in 1-chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. NCM 1921 significantly ameliorated the macroscopic and microscopic signs and reduced skin thickness and mast cell incorporation in the skin lesions of mice with DNCB-induced AD. Furthermore, it reduced serum immunoglobulin E levels; reduced the number of IgE-producing B cells, peripheral blood mononuclear cells, white blood cells, and differential white blood cells; and increased the number of lymphocytes. NCM 1921 normalized the total cell number in dorsal skin tissue, the axillary lymph node, and spleen following DNCB exposure and reduced the number of CD23+/B220+ cells in the axillary lymph node and CD3+ cells in dorsal skin tissue. Moreover, it reduced the levels of interleukin (IL)-4 and IL-13 but increased the levels of interferon-γ in anti-CD3-stimulated splenocytes. Immunohistofluorescence staining showed that NCM 1921 treatment significantly increased claudin1, filaggrin, and Sirt1 protein expressions in AD skin lesions. These results suggest that NCM 1921 could be a valuable remedy for the treatment of AD.

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“…Recently, a ratio of EPA : DHA 6 : 1 has been recognized as a potent formulation to improve endothelial functions in different studies. Intake of omega-3 formulation EPA : DHA 6 : 1 can restore endothelium-dependent NO-mediated relaxations, most likely, by preventing the upregulation of the local angiotensin system, NADPH oxidase, and the subsequent formation of ROS in old rats [ 218 ]. Also, EPA : DHA 6 : 1 can prevent endothelial senescence in middle-aged or old rats by limiting both the shedding of endothelial microvesicles and their prosenescent, prothrombotic, and proinflammatory effects in endothelium [ 218 ].…”

Section: Diet Effect On Endothelial Function and Oxidative Stressmentioning

confidence: 99%

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Man

Xia

2020

Oxidative Medicine and Cellular Longevity

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Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.

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Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery

Cited by 22 publications

References 56 publications

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

NCM 1921, a Mixture of Several Ingredients, Including Fatty Acids and Choline, Attenuates Atopic Dermatitis in 1-Chloro-2,4-Dinitrobenzene-Treated NC/Nga Mice

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

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