Intake of Lactobacillus plantarum Reduces Certain Gastrointestinal Symptoms During Treatment With Antibiotics

Abstract

Our results indicate that intake of L. plantarum could have a preventive effect on milder gastrointestinal symptoms during treatment with antibiotics.

Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes

“…29 Nursing home residence has been previously shown to increase the risk of carriage of antibiotic-resistant organisms. 30,41,84 Although we found no association between recent hospitalisation and carriage of resistant organisms, an association was found in a recent study investigating risk factors for drug-resistant pathogens in community-acquired and health care-associated pneumonia. 84 The sample of care home residents recruited for this aspect of the research was representative of those recruited to the main cohort study.…”

“…Recent antibiotic use has been shown to be a key risk factor for carriage of antibiotic-resistant organisms in previous studies. 20,[22][23][24][25]32,84,85 Previous antibiotic use has also been shown to be a risk factor for the presence of extended-spectrum beta-lactamase-producing strain of bacteria in long-term care. 86 A dose-response association has been proposed by one study 27 and multidrug resistance has been linked to non-hospital antimicrobial consumption.…”

Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus

“…These bacteria have demonstrated a number of beneficial roles, especially in the GIT (17), including lowering the duration and incidence of diarrhea during antibiotic treatment, protection against pathogens, interaction with dendritic and T cells, and reduced risk of Clostridium difficileassociated disease (3,5,10,13). There are intimate communications between the resident gut microbes and transient microbes with the epithelial layer and immune cells embedded within the GIT.…”

Using Probiotics Instead of Pharmaceuticals to Treat Gastrointestinal Disorders

“…The probiotic strains L. plantarum 299v and L. reteuri have been shown to reduce gastrointestinal symptoms such as diarrhea, inflammation, overgrowth of pathogenic bacteria and decreased intestinal barrier function which can lead to leaky gut syndrome [19,20]. According to Orel, "several Lactobacillus reuteri strains exhibit various characteristics such as secretion of antimicrobial reuterin, production of short-chain fatty acids, down-regulation of inflammatory immune response, and direct influence on enteric nervous system among the others, which render them good candidates for prevention and treatment of various FGIDs" [20].…”