Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age–sex-matched controls

Gopinath, Bamini; Liew, Gerald; Russell, Joanna; Cosatto, Victoria F.; Burlutsky, George; Mitchell, Paul

doi:10.1136/bjophthalmol-2016-309490

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…Unlike in other studies [ 8 , 16 ], no statistically significant associations were observed in nonsmokers and AMD. We found inverse associations between F&V and AMD in current smokers only.…”

Section: Discussioncontrasting

confidence: 99%

“…We found inverse associations between F&V and AMD in current smokers only. Several studies reported that high fruit and vegetable intake is inversely associated with AMD [ 8 , 16 ]. A cross-sectional study conducted in Australia showed that the proportion of individuals who met the recommended daily intake of vegetables was lower amongst patients with late-stage AMD than in a population of age- and sex-matched controls with no signs of AMD (52.9% vs. 64.5%, p = 0.0002) [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness in older adults [ 1 ]. Several studies have identified risk factors for AMD, including age [ 2 ], family history [ 3 ], diabetes mellitus [ 4 ], alcohol consumption [ 5 ], cigarette smoking [ 6 , 7 ] and dietary factors [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most previous studies on the associations between diet and AMD have been conducted in Western countries, including America [ 26 , 27 ], Europe [ 28 , 29 ], and Australia [ 8 , 9 ]. In Asia, several studies have been conducted in Japan [ 19 , 30 ], China [ 31 ], and India [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Associations between fruit and vegetable, and antioxidant nutrient intake and age-related macular degeneration by smoking status in elderly Korean men

Kim

Vijayakumar

et al. 2017

Nutr J

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BackgroundAge-related macular degeneration (AMD) is one of the major causes of irreversible blindness. The objective of this study was to determine whether there is any relationship between dietary intake of fruits and vegetables (F&V) and antioxidant nutrients including carotenoids and AMD according to smoking status in elderly men.MethodsWe performed a cross-sectional analysis using nationally representative samples of elderly aged ≥ 65 years (n = 1414) from the Korea National Health and Nutrition Examination Survey (KNHANES, 2010–2012).ResultsThe current smokers consumed less food in total, and, in particular, less cereals/potatoes/sugar products, fruits and vegetables than the nonsmokers and former smokers (p < 0.05). Intake of energy, thiamin, vitamin C, vitamin A, and β-carotene were significantly lower in the current smokers than in the nonsmokers and the former smokers. For current smokers, the ORs of the highest tertile compared with the lowest tertile were 0.36 (95% CI: 0.14–0.96, p for trend = 0.0576) for F&V, 0.32 (95% CI: 0.12–0.85, p for trend = 0.0561) for vitamin C, 0.23 (95% CI: 0.08–0.67, p for trend = 0.0038) for α-carotene, 0.13 (95% CI: 0.04–0.46, p for trend = 0.0003) for β-carotene after adjusting for confounding factors. In contrast, there was no association between antioxidant nutrient intake and AMD among the nonsmokers and former smokers.ConclusionsThese results suggest that increased consumption of fruits and vegetables containing antioxidant components such as vitamin C, α-carotene, and β-carotene may have a protective effect on AMD. These effects may be more evident among current smokers.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between fruit and vegetable, and antioxidant nutrient intake and age-related macular degeneration by smoking status in elderly Korean men

Kim

Vijayakumar

et al. 2017

Nutr J

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“…Data from the FFQ were coded into a customized database that incorporated the nutrient tables for use in Australia (NUTTAB 2010) . Nutrient associations for energy‐adjusted intake were between 0.50 and 0.60, similar to other studies . Foods were categorized into major food categories and sub‐categories to determine servings per day.…”

Section: Methodssupporting

confidence: 75%

Dietary zinc intake is associated with macular fluid in neovascular age‐related macular degeneration

Detaram

Russell

Burlutsky

et al. 2019

Clinical Exper Ophthalmology

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Importance: Numerous dietary factors have been shown to reduce progression from early to late age-related macular degeneration (AMD), however, little is known on their impact in patients diagnosed with late-stage disease. Background: To determine whether a dietary intake high in antioxidants and zinc, fruits, vegetables and fish is associated with favourable clinical outcomes in patients with neovascular AMD (nAMD) undergoing anti-vascular endothelial growth factor therapy. Design: Cross-sectional study carried out at a private ophthalmology clinic. Participants: Five hundred forty-seven participants with nAMD.Methods: Diet was determined using a validated food frequency questionnaire.Presence of intra-retinal and sub-retinal fluid (IRF, SRF), pigment epithelial detachment and central macular thickness (CMT) were recorded from ocular coherence tomography images. Main Outcome Measures: Fluid presence, mean CMT and visual acuity.Results: Participants with daily zinc intake below (n = 91) vs above (n = 333) 8.1 mg had greater odds of SRF being present, multivariable-adjusted odds ratio (OR) of 0.56 (95% CI 0.36-0.96). This association was stronger in persons with at least 6 months of treatment, OR of 0.32 (95% CI 0.14-0.75). In the entire cohort, participants in the lowest or first quartile compared to those in the upper three quartiles of zinc intake combined had significantly greater mean CMT (254.81 μm vs 232.15 μm, respectively, multivariable-adjusted P = .03). Conclusions and Relevance: Low dietary zinc intake was associated with a greater likelihood of SRF presence, particularly in those treated for at least 6 months, and increased macular thickness in treated eyes with nAMD. K E Y W O R D Sage-related macular degeneration, epidemiology, micronutrient

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Zinc Nutrition and Inflammation in the Aging Retina

Gilbert

Pető²,

Lengyel³

et al. 2019

Molecular Nutrition Food Res

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Zinc is an essential nutrient for human health. It plays key roles in maintaining protein structure and stability, serves as catalytic factor for many enzymes, and regulates diverse fundamental cellular processes. Zinc is important in affecting signal transduction and, in particular, in the development and integrity of the immune system, where it affects both innate and adaptive immune responses. The eye, especially the retina‐choroid complex, has an unusually high concentration of zinc compared to other tissues. The highest amount of zinc is concentrated in the retinal pigment epithelium (RPE) (RPE‐choroid, 292 ± 98.5 µg g−1 dry tissue), followed by the retina (123±62.2 µg g−1 dry tissue). The interplay between zinc and inflammation has been explored in other parts of the body but, so far, has not been extensively researched in the eye. Several lines of evidence suggest that ocular zinc concentration decreases with age, especially in the context of age‐related disease. Thus, a hypothesis that retinal function could be modulated by zinc nutrition is proposed, and subsequently trialled clinically. In this review, the distribution and the potential role of zinc in the retina‐choroid complex is outlined, especially in relation to inflammation and immunity, and the clinical studies to date are summarized.

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Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age–sex-matched controls

Abstract: This study showed significant differences in intakes of vitamins C and E, beta-carotene, folate and vegetables between patients with late-stage AMD and healthy controls, and thus has provided a better understanding of the nutritional intake of patients presenting with advanced AMD.

Cited by 21 publications

References 30 publications

Associations between fruit and vegetable, and antioxidant nutrient intake and age-related macular degeneration by smoking status in elderly Korean men

Associations between fruit and vegetable, and antioxidant nutrient intake and age-related macular degeneration by smoking status in elderly Korean men

Dietary zinc intake is associated with macular fluid in neovascular age‐related macular degeneration

Zinc Nutrition and Inflammation in the Aging Retina

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