Intake of fruit and vegetables and risk of bladder cancer: a dose–response meta-analysis of observational studies

Yao, Baodong; Yan, Yujie; Ye, Xian-Wu; Fang, Hong; Xu, Huilin; Liu, Yinan; Li, Sheran; Zhao, Yongqiang

doi:10.1007/s10552-014-0469-0

Cited by 45 publications

(37 citation statements)

References 48 publications

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“…The MA by Yao et al [19] was selected as the most comprehensive publication for overall fruit and vegetable intake and reported significant protective effect on bladder cancer (RR 0.81; 95 % CI 0.67–0.99; I 2 = 58.4 %; n = 10).…”

Section: Resultsmentioning

confidence: 99%

“…MA by Yao et al [19] was selected as most comprehensive for consumption of overall fruit and the MA by Liang et al [20] for intake of citrus fruit (e.g. oranges, lemons, limes, and grapefruits;).…”

Section: Resultsmentioning

confidence: 99%

“…Overall fruit was associated with a reduced risk of bladder cancer (RR 0.77; 95 % CI 0.69–0.87; I 2 = 54.9 %; n = 27) as were citrus fruit (highest vs. lowest intake: RR 0.85; 95 % CI 0.76–0.94; I 2 = 72.1 %; n = 14). Yao et al [19] reported significant publication bias for overall and citrus fruit intake.…”

Section: Resultsmentioning

confidence: 99%

“…By pooling results from Yao et al [19] and Steinmaus et al [21] in a MMA, the most comprehensive estimate could be obtained for overall vegetable consumption (n = 31 unique and n = 3 duplicate primary studies). The MA by Yao et al [19] was selected as the most comprehensive publication for cruciferous vegetables.…”

Section: Resultsmentioning

confidence: 99%

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Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses

et al. 2016

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Each year, 430,000 people are diagnosed with bladder cancer. Due to the high recurrence rate of the disease, primary prevention is paramount. Therefore, we reviewed all meta-analyses on modifiable risk factors of primary bladder cancer. PubMed, Embase and Cochrane database were systematically searched for meta-analyses on modifiable risk factors published between 1995 and 2015. When appropriate, meta-analyses (MA) were combined in meta–meta-analysis (MMA). If not, the most comprehensive MA was selected based on the number of primary studies included. Probability of causation was calculated for individual factors and a subset of lifestyle factors combined. Of 1496 articles identified, 5 were combined in MMA and 21 were most comprehensive on a single risk factor. Statistically significant associations were found for current (RR 3.14) or former (RR 1.83) cigarette smoking, pipe (RR 1.9) or cigar (RR 2.3) smoking, antioxidant supplementation (RR 1.52), obesity (RR 1.10), higher physical activity levels (RR 0.86), higher body levels of selenium (RR 0.61) and vitamin D (RR 0.75), and higher intakes of: processed meat (RR 1.22), vitamin A (RR 0.82), vitamin E (RR 0.82), folate (RR 0.84), fruit (RR 0.77), vegetables (RR 0.83), citrus fruit (RR 0.85), and cruciferous vegetables (RR 0.84). Finally, three occupations with the highest risk were tobacco workers (RR 1.72), dye workers (RR 1.58), and chimney sweeps (RR 1.53). The probability of causation for individual factors ranged from 4 to 68 %. The combined probability of causation was 81.8 %. Modification of lifestyle and occupational exposures can considerably reduce the bladder cancer burden. While smoking remains one of the key risk factors, also several diet-related and occupational factors are very relevant.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses

et al. 2016

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“…A metaanalysis published in 2014 confirmed the role of fruits and vegetables in the reduction of bladder cancer risk [39]; the findings of Park et al, however, suggest that their intake may only lower cancer incidence in women [40]. A metaanalysis performed by Xu et al only confirmed the beneficial effects of green leafy vegetables [38].…”

Section: Fruits and Vegetablesmentioning

confidence: 99%

Bladder cancer prevention

Długosz

Królik²

2017

Nowotwory. Journal of Oncology

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Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

Jochems

Reulen

Osch

et al. 2020

Intl Journal of Cancer

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While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products. Analyses were stratified by sex, smoking status and bladder cancer subtype. During on average 11.2 years of follow‐up, 2836 individuals developed incident bladder cancer. Increasing fruit consumption (by 100 g/day) was inversely associated with the risk of bladder cancer in women (HR = 0.92; 95% CI 0.85‐0.99). Although in women the association with fruit consumption was most evident for higher‐risk nonmuscle invasive bladder cancer (NMIBC; HR = 0.72; 95% CI 0.56‐0.92), the test for heterogeneity by bladder cancer subtype was nonsignificant (P‐heterogeneity = .14). Increasing fruit consumption (by 100 g/day) was not associated with bladder cancer risk in men (HR = 0.99; 95% CI 0.94‐1.03), never smokers (HR = 0.96; 95% CI 0.88‐1.05), former smokers (HR = 0.98; 95% CI 0.92‐1.05) or current smokers (HR = 0.95; 95% CI 0.89‐1.01). The consumption of any type of fruit was not found to be associated with bladder cancer risk (P values > .05). Our study supports no evidence that the consumption of specific types of fruit reduces the risk of bladder cancer. However, increasing total fruit consumption may reduce bladder cancer risk in women.

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Intake of fruit and vegetables and risk of bladder cancer: a dose–response meta-analysis of observational studies

Abstract: This meta-analysis supports the hypothesis that intakes of fruit and vegetables may reduce the risk of bladder cancer. Future well-designed studies are required to confirm this finding.

Cited by 45 publications

References 48 publications

Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses

Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses

Bladder cancer prevention

Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

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