Intake of dietary saturated fatty acids and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort: associations by types, sources of fatty acids and substitution by macronutrients

Liu, Shengxin; Schouw, Yvonne T. van der; Soedamah‐Muthu, Sabita S.; Spijkerman, Annemieke M.W.; Sluijs, Ivonne

doi:10.1007/s00394-018-1630-4

Cited by 40 publications

(33 citation statements)

References 44 publications

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“…Meat is a source of SFA and dietary cholesterol, but neither total dietary SFA [43], nor dietary cholesterol [44] have been associated with increased risk of T2DM in recent studies. Those conclusions were contrary to results obtained in the study by Guess et al [45] in which researchers compared the intake of fatty acids between normoglycaemic participants, prediabetes participants and participants with type 2 diabetes, and provided observation that increased consumption of saturated fatty acids was associated not only with higher risk of impaired fasting glucose and higher concentration of glucose after 2h in OGTT (Oral Glucose Tolerance Test), but also with insulin resistance.…”

Section: Meat Fish Eggsmentioning

confidence: 99%

Food groups in dietary prevention of type 2 diabetes

Basiak-Rasała

Różańska

Zatońska

2019

Rocz Panstw Zakl Hig

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According to the World Health Organization diabetes will be the seventh leading cause of death worldwide in 2030. Majority of diabetic patients suffer from type 2 diabetes (T2DM), which is mostly avoidable. The most important modifiable risk factors of type 2 diabetes are: overweight and obesity, improper diet, sedentary lifestyle and tobacco smoking. Even in prediabetic state, improving diet and physical activity can slow down or even stop progression to diabetes. In the view of health burden of diabetes it is essential to thoroughly investigate the risk factors and develop more specific preventive strategies. Recently published studies focus on food groups rather than individual products to assess the link between nutrition and risk of type 2 diabetes. Identifying food groups of possible beneficial and deleterious effect on the risk of type 2 diabetes could facilitate the dietary counselling. The aim of the overview is to summarize the possible association between consumption of food groups on the risk of type 2 diabetes on the basis of available literature. Observations from studies and meta-analyses indicate on an inverse association between consumption of fresh vegetables and fruit, whole grains, lean dairy, fish, nuts and the risk of type 2 diabetes. Food groups that seemed to increase the risk of type 2 diabetes are: red and processed meat, refined grains, sugar-sweetened beverages. It is important to note, that no individual nutrients, but diverse dietary pattern, composed of every recommended food group in adequate amounts can contribute to healthy lifestyle and T2DM prevention.

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Section: Meat Fish Eggsmentioning

confidence: 99%

Food groups in dietary prevention of type 2 diabetes

Basiak-Rasała

Różańska

Zatońska

2019

Rocz Panstw Zakl Hig

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“…On the other hand, we found higher levels of the dietary odd-chain saturated fatty acids (OCFAs) pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) in beef than in the soy-based alternative. These compounds are believed to exert their beneficial effects by attenuating inflammation, dyslipidemia, and cell fibrosis 23 , and increased dietary intake is associated with a lower risk of metabolic disease 24,25 .…”

Section: Untargeted Metabolomics Of Plant-based Meat and Beefmentioning

confidence: 99%

Impossible to go Beyond Beef? A Nutriomics Comparison

Vliet

Bain

Muehlbauer

et al. 2020

Preprint

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Concerns regarding the effects of red meat on human and environmental health are prompting consumer interest in plant-based diets. As global food systems strive to meet the dietary needs of an estimated mid-century population of 10 billion, a new generation of plant-based meat alternatives—formulated to mimic the taste and nutritional composition of red meat—have attracted considerable consumer interest, research attention, and media coverage. We used untargeted metabolomics to provide an in-depth comparison of the nutrient profiles of grass-fed ground beef and a market-leading plant-based meat alternative. Metabolomics revealed a 90% difference in nutritional profiles beef and a popular plant-based meat, many of which can have important consumer health implications. This information could not be determined from their Nutrition Facts, which suggests nutritional similarity. Our findings indicate that beef and a popular plant-based meat should not be viewed as nutritionally interchangeable, but as complementary in terms of provided nutritional entities. As society aims to increase food production with ~ 60% by 2050, the meat and the plant-based meat industries will likely coexist and have to complement each other in order this reach this goal.

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“…Despite increases in risk factors, particularly LDL, preclinical rodent models employing coconut oil have failed to observe expected atherogenic 25,26 and diabetogenic 27 phenotypes. Both clinical trial 28 and observational epidemiological investigations 29,30 have suggested beneficial cardiometabolic effects of C12:0 relative to other saturated fatty acids. Such observations are consistent with pleiotropic effects of C12:0, though few have been described to date, apart from C12:0’s relative high oxidation rate in vivo 31 and ability to activate toll-like receptors at high concentrations in vitro 32–34 .…”

Section: Introductionmentioning

confidence: 99%

LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation

Klatt

Zhang

Malysheva

et al. 2021

Preprint

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BackgroundThe unusual phosphatidylcholine species, dilauroylphosphatidylcholine (DLPC), has been reported to bind and activate the orphan nuclear receptor, liver receptor homolog-1 (LRH-1). To date, DLPC has not been reported endogenously in metabolomic databases.ObjectiveHerein, we test the hypothesis that the provision of the acyl constituent of DLPC, lauric acid (C12:0), a saturated fatty acid rich in tropical oils such as coconut oil, will 1) result in endogenous DLPC production and 2) enhance LRH-1 transcriptional activity.MethodsWe measured DLPC following provision of C12:0 to HepG2 cells, C57/BL6J mice, and to healthy human participants in an acute, randomized, controlled cross-over trial. LRH-1fl/fl and LRH-1fl/fl Albumin-Cre mice were used in ex vivo and in vivo approaches. to assess the impact of C12:0 on LRH-1 target gene expression. 1-13C-lauric acid and methyl-d9-choline were used to assess DLPC production dynamics.ResultsDLPC was not observed in any C12:0-free approach. Provision of C12:0 in the culture media or to C57/BL6J mice resulted in the rapid production of DLPC, including DLPC’s presence in multiple LRH-1 expressing tissues. Coconut oil-fed human participants exhibited DLPC in postprandial serum samples. Ex vivo and in vivo C12:0 provision resulted in increased mRNA expression of LRH-1 target genes, an effect that was not observed in hepatic knockout mice. Methyl-d9-choline administration revealed a complex reliance on CDP-choline-derived DLPC.ConclusionC12:0 provision results in endogenous production of the LRH-1 ligand, DLPC, and LRH-1 transcriptional activation phenotypes. Our findings highlight pleiotropic effects of lauric acid, a common hypercholesterolemic dietary saturated fatty acid, secondary to LRH-1 agonism.

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Intake of dietary saturated fatty acids and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort: associations by types, sources of fatty acids and substitution by macronutrients

Cited by 40 publications

References 44 publications

Food groups in dietary prevention of type 2 diabetes

Food groups in dietary prevention of type 2 diabetes

Impossible to go Beyond Beef? A Nutriomics Comparison

LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation

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