Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke

Vissers, Linda E.T.; Dalmeijer, Geertje W.; Boer, Jolanda M. A.; Schouw, Yvonne T. van der; Beulens, Joline W.J.

doi:10.1161/jaha.113.000455

Cited by 40 publications

(41 citation statements)

References 46 publications

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“…Another nutrient present in cheese is menaquinone-n, which was inversely associated with CVD risk in several previous cohort studies (29,30) . However, a previous study in the EPIC-NL cohort has found no association between menaquinone-n intake and stroke incidence (31) , so we find it very unlikely that this micronutrient explains our association. Moreover, the present results are not consistent with those of recent observational studies that reported no consistent associations between cheese intake and stroke incidence (11,32,33) , and a previous analysis in the EPIC-NL cohort has shown no association between cheese intake and stroke incidence (7) .…”

Section: Discussioncontrasting

confidence: 73%

The relationship between fermented food intake and mortality risk in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort

et al. 2015

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The objective of the present study was to investigate the relationship between total and subtypes of bacterial fermented food intake (dairy products, cheese, vegetables and meat) and mortality due to all causes, total cancer and CVD. From the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort, 34 409 Dutch men and women, aged 20-70 years who were free from CVD or cancer at baseline, were included. Baseline intakes of total and subtypes of fermented foods were measured with a validated FFQ. Data on the incidence and causes of death were obtained from the national mortality register. Cox proportional hazards models were used to analyse mortality in relation to the quartiles of fermented food intake. After a mean follow-up of 15 (SD 2·5) years, 2436 deaths occurred (1216 from cancer and 727 from CVD). After adjustment for age, sex, total energy intake, physical activity, education level, hypertension, smoking habit, BMI, and intakes of fruit, vegetables and alcohol, total fermented food intake was not found to be associated with mortality due to all causes (hazard ratio upper v. lowest quartile (HR Q4 v. Q1 ) 1·00, 95 % CI 0·88, 1·13), cancer (HR Q4 v. Q1 1·02, 95 % CI 0·86, 1·21) or CVD (HR Q4 v. Q1 1·04, 95 % CI 0·83, 1·30). Bacterial fermented foods mainly consisted of fermented dairy foods (78 %) and cheese (16 %). None of the subtypes of fermented foods was consistently related to mortality, except for cheese which was moderately inversely associated with CVD mortality, and particularly stroke mortality (HR Q4 v. Q1 0·59, 95 % CI 0·38, 0·92, P trend ¼ 0·046). In conclusion, the present study provides no strong evidence that intake of fermented foods, particularly fermented dairy foods, is associated with mortality.

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Section: Discussioncontrasting

confidence: 73%

The relationship between fermented food intake and mortality risk in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort

et al. 2015

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“…Despite promising results in pre-clinical animal models, clinical trials haven't demonstrated any benefit in man [43][44][45][46]. Vitamin K supplementation is safe in human and interventional studies are needed to determine if vitamin K supplementation could prevent diabetic peripheral neuropathy [47,48].…”

Section: Discussionmentioning

confidence: 99%

Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes

et al. 2020

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Aims/Hypothesis Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrixgla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role in peripheral nervous system homeostasis. The aim of this study was to evaluate factors associated with sensitive diabetic neuropathy in Type 2 Diabetes, and, in particular, dephospho-uncarboxylated MGP (dp-ucMGP), the inactive form of MGP. Methods 198 patients with Type 2 Diabetes were included. Presence of sensitive diabetic neuropathy was defined by a neuropathy disability score (NDS) �6. Plasma levels of dp-ucMGP were measured by ELISA.

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“…No side events were recorded in a Japanese trial of 2185 postmenopausal osteoporotic women receiving 45 mg menatetrenone for 3 years [ 10 ]. Vitamin K intake was not associated with stroke risk in a prospective cohort of 35 476 healthy subjects [ 11 ]. Another potential problem relates to the vitamin K-dependent carboxylation of osteocalcin, also termed Bone Gla protein [ 12 ].…”

Section: Background and Objectivesmentioning

confidence: 99%

The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials

et al. 2015

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BackgroundThe extent and the progression of vascular calcification (VC) are independent predictors of cardiovascular risk in the haemodialysis population. Vitamin K is essential for the activation of matrix gla protein (MGP), a powerful inhibitor of tissue calcification. Functional vitamin K deficiency may contribute to the high VC burden in haemodialysis patients. In addition, haemodialysis patients are frequently treated with vitamin K antagonists, mainly to prevent stroke in atrial fibrillation, potentially compounding the cardiovascular risk in these already vulnerable patients. New oral anticoagulants (NOACs) are valuable alternatives to vitamin K antagonists in the general population, but their use in dialysis has been encumbered by substantial renal clearance. However, a recent pharmacokinetic study provided information on how to use rivaroxaban in haemodialysis patients.MethodsWe conduct a randomized, prospective, multicentre, open-label interventional clinical trial that will include 117 chronic haemodialysis patients with non-valvular atrial fibrillation, treated with or candidates for treatment with vitamin K antagonists. Patients will be randomized to a vitamin K antagonist titrated weekly to an international normalized ratio between 2 and 3, a daily dose of rivaroxaban of 10 mg, or a daily dose of rivaroxaban 10 mg with a thrice weekly supplement of 2000 µg vitamin K2. Cardiac computed tomography, pulse wave velocity (PWV) measurements and MGP sampling will be performed at baseline, 6 months, 12 months and 18 months. Primary endpoints include progression of coronary artery and thoracic aorta calcification and changes in PWV. Secondary endpoints are progression of aortic and mitral valve calcification, all-cause mortality, major adverse cardiovascular events, stroke and bleeding. The ClinicalTrials.gov database was searched to retrieve related trials.ResultsSeven trials, three of which are performed in the haemodialysis population, evaluate whether pharmacological doses of vitamin K1 or K2 retard progression of VC. Five studies compare the effect of warfarin and NOACs on progression of VC, the present study being the only conducted in the dialysis population.ConclusionVitamin K deficiency may be a modifiable cardiovascular risk factor in the haemodialysis population. Conversely, vitamin K antagonists may aggravate VC burden in haemodialysis patients. Several ongoing trials may provide an answer to these questions in the near future.

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Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke

Cited by 40 publications

References 46 publications

The relationship between fermented food intake and mortality risk in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort

The relationship between fermented food intake and mortality risk in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort

Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes

The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials

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