Intake of Air-Oxidized Soybean Oil by Dams Does Not Affect Whole Body Lipid Peroxide Contents of Their Newborn and Suckling Pups.

Abstract

whether or not the feeding of air-oxidized oil to rat dams during the period of gestation or lactation affects the lipid peroxide contents in their offspring was studied. Rat dams were given a diet containing 4 g soybean oil or air-oxidized soybean oil/ 100 g diet during gestation. Whole body lipid peroxides, thiobarbituric acid-reactive substances (TBARS) determined as malondialdehyde, in newborn pups from dams fed the air-oxidized oil diet were not different from those from dams fed the unoxidized oil diet. When dams were given the oxidized oil diet during lactation, whole body TBARS contents in suckling pups increased sharply in the 10-day-old neonate and decreased until 21 days old. However, these trends were not affected by the amounts of air-oxidized soybean oil nor the unoxidized oil diet. These findings indicate that a maternal diet containing air-oxidized oil during gestation or lactation does not affect the whole body lipid peroxides in neonatal rats.

Evaluation of Lipid Peroxide Metabolism in Neonatal Rats during Suckling: Developmental Changes in Whole Body Lipid Peroxides.

“…The lipid peroxide level in the present artificial milk diet (19.6 nmol MDA/ml) was not significantly different from that in the milk from rat dams (20.8-24.0 nmol MDA/ml) [9], but was higher than that in the skimmed milk diet (trace). These results suggest that the increase in whole body TBARS content during the early period of suckling was partly related to a possible increase in milk consumption in newborn rats.…”

“…These trends were also confirmed by the findings on in viva and in vitro ethane production, which is considered to be an index of lipid peroxidation [1,11]. However, these observations do not agree with our previous study [9], where whole body TBARS contents of 10-day-old animals were significantly higher than those of 21-day-old ones. Because litter size was not adjusted in experiment 1-A, a possible effect of milk consumption on body growth may have caused the differences between both studies.…”

“…In the previous study, we reported [9] that the whole body TBARS content in newborn pups was very low. This was also observed in the present study.…”

“…We previously reported [8] that more than 80 % of the total TBARS content in the rat body is distributed in the carcass portion. Furthermore, we observed [9] that the whole body TBARS content of 10-day-old rats was significantly higher than that of 21-day-old ones.…”