Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice

Liisberg, Ulrike; Fauske, Kristin Røen; Kuda, Ondřej; Fjære, Even; Myrmel, Lene Secher; Norberg, Nina; Frøyland, Livar; Graff, Ingvild Eide; Liaset, Bjørn; Kristiansen, Karsten; Kopecký, Jan; Madsen, Lise

doi:10.1016/j.jnutbio.2016.03.014

Cited by 35 publications

(42 citation statements)

References 173 publications

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“…In particular, when the effects of high-protein diets are examined, casein as a protein source does not seem to be representative. 33,50 The pattern of digestion of casein is unique, and casein has been shown to affect gut hormones involved in glucose metabolism by generating an insulinotropic effect and affecting the absorption rate of different amino acids. 51 Thus, the use of casein as a control protein can arguably be a limitation.…”

Section: Discussion Of Results From Animal Studiesmentioning

confidence: 99%

“…A recent study investigated whether changing the protein source from pork to cod in a regular Western diet would alter the endocannabinoid tone in mice and thereby reduce both the development of obesity and the accumulation of fat in the liver. 33 The results showed that the cod-fed mice had significantly lower concentrations of 2 major circulating endocannabinoids, a lower increase in adipose tissue, and a lower content of hepatic lipids than the pork-fed mice. Protein from seafood has a high content of taurine, and a negative correlation between adiposity and intake of taurine and glycine has been demonstrated in mice fed chicken, cod, crab, or scallop in high-fat, high-sucrose diets.…”

Section: Studies With Intact Fish Proteinmentioning

confidence: 93%

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Fish–derived proteins and their potential to improve human health

2019

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Emerging evidence from studies evaluating the effect of lean fish consumption in humans suggests that proteins from fish have several beneficial metabolic effects. Rest, or waste, material from the fishing industry contains high-quality proteins, and utilization of this material offers novel possibilities for the development of protein-containing products that might be beneficial for human consumption. Fish-derived peptides containing bioactive amino acid sequences suggested to beneficially influence pathways involved in body composition, hypertension, lipid profile, and regulation of glucose metabolism are of particular interest, although the results of published studies are conflicting. This review aims to summarize current knowledge from animal studies and clinical interventions in humans evaluating the effects of lean fish, fish proteins, and fish-derived peptides on outcomes related to metabolic health. Fish proteins have a high content of taurine, and animal trials suggest that taurine mediates some of the beneficial effects observed thus far, although the mechanisms by which fish peptides exert their action are not yet elucidated. At this time, the literature is inconsistent, and there is insufficient mechanistic evidence to support a beneficial effect of fish-derived peptides on metabolic health.

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Section: Discussion Of Results From Animal Studiesmentioning

confidence: 99%

Section: Studies With Intact Fish Proteinmentioning

confidence: 93%

Fish–derived proteins and their potential to improve human health

2019

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“…Whether these differences in the abundance of microbial genes were of physiological relevance is still not clear. In a similar dietary setting, obesity development was attenuated in mice by exchanging lean pork meat with cod (Liisberg et al, 2016a ). Further, intake of lean seafood such as white crab meat, scallop, and a mixture of cod and scallops has been demonstrated to attenuate diet-induced obesity and hepatic steatosis in mice (Tastesen et al, 2014a , b ).…”

Section: Protein Sources Gut Microbiota and Obesitymentioning

confidence: 99%

Links between Dietary Protein Sources, the Gut Microbiota, and Obesity

Madsen¹,

Myrmel²,

Fjære³

et al. 2017

Front. Physiol.

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The association between the gut microbiota and obesity is well documented in both humans and in animal models. It is also demonstrated that dietary factors can change the gut microbiota composition and obesity development. However, knowledge of how diet, metabolism and gut microbiota mutually interact and modulate energy metabolism and obesity development is still limited. Epidemiological studies indicate an association between intake of certain dietary protein sources and obesity. Animal studies confirm that different protein sources vary in their ability to either prevent or induce obesity. Different sources of protein such as beans, vegetables, dairy, seafood, and meat differ in amino acid composition. Further, the type and level of other factors, such as fatty acids and persistent organic pollutants (POPs) vary between dietary protein sources. All these factors can modulate the composition of the gut microbiota and may thereby influence their obesogenic properties. This review summarizes evidence of how different protein sources affect energy efficiency, obesity development, and the gut microbiota, linking protein-dependent changes in the gut microbiota with obesity.

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“…Zhu et al [52] have also found that the oligopeptides from Marine Salmo (Oncorhynchus keta) skin could significantly reduce the fasting blood glucose in diabetic rats, and they concluded that the antidiabetic activity may be mediated by downregulating T2DM-related oxidative stress and inflammation. Moreover, as obesity has become a serious public health problem throughout the entire world, some marine peptides were found to have antiobesity activity, such as Seaweeds [95], Cod [96], Blue Whiting (Micromesistius poutassou) , Brown Shrimp (Penaeus aztecus) [53], and other marine organisms [97]. Although marine organisms comprise roughly one-half of the total global biodiversity and a number of studies exist for proving the biological effects using in vitro experiments or animal models, it is now important to use human intervention trials to study the biological effects and their mechanisms in more detail [86, 98].…”

Section: Marine Peptides With Different Bioactivitiesmentioning

confidence: 99%

Characterization, Preparation, and Purification of Marine Bioactive Peptides

Wang

Xing

et al. 2017

BioMed Research International

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Marine bioactive peptides, as a source of unique bioactive compounds, are the focus of current research. They exert various biological roles, some of the most crucial of which are antioxidant activity, antimicrobial activity, anticancer activity, antihypertensive activity, anti-inflammatory activity, and so forth, and specific characteristics of the bioactivities are described. This review also describes various manufacturing techniques for marine bioactive peptides using organic synthesis, microwave assisted extraction, chemical hydrolysis, and enzymes hydrolysis. Finally, purification of marine bioactive peptides is described, including gel or size exclusion chromatography, ion-exchange column chromatography, and reversed-phase high-performance liquid chromatography, which are aimed at finding a fast, simple, and effective method to obtain the target peptides.

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Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice

Cited by 35 publications

References 173 publications

Fish–derived proteins and their potential to improve human health

Fish–derived proteins and their potential to improve human health

Links between Dietary Protein Sources, the Gut Microbiota, and Obesity

Characterization, Preparation, and Purification of Marine Bioactive Peptides

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