Intact serotonergic and dopaminergic systems in two cases of orthostatic tremor

Wegner, Florian; Strecker, Karl; Boeckler, David; Wagner, A.; Preul, Christoph; Lobsien, Donald; Sabri, Osama; Hesse, Swen

doi:10.1007/s00415-008-0023-7

Cited by 14 publications

(8 citation statements)

References 14 publications

(17 reference statements)

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“…This notwithstanding, we cannot exclude borderline dopaminergic deficit in some cases. However, our findings corroborate and further extend three previous smaller reports10 19 20 that also failed to find reductions in striatal dopamine transporter tracer binding and indeed dopaminergic drugs are unhelpful for OT. Finally, despite rare reports of cerebellar ataxia associated with OT,7 8 21 22 we could not identify any in our cases.…”

Section: Discussionsupporting

confidence: 92%

The long-term outcome of orthostatic tremor

Ganos

Maugest

Apartis

et al. 2015

J Neurol Neurosurg Psychiatry

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Section: Discussionsupporting

confidence: 92%

The long-term outcome of orthostatic tremor

Ganos

Maugest

Apartis

et al. 2015

J Neurol Neurosurg Psychiatry

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“…Those patients did not have any neurological sign apart from OT and had a normal olfactory function, supporting the idea that they did not have Parkinson's disease (PD) . However, evidence of dopaminergic deficits has not been found in other imaging studies . Moreover, there was no follow‐up on the patients reported by Katzenschlager et al., and it is unknown whether they further developed frank PD.…”

Section: Orthostatic Tremormentioning

confidence: 74%

Shaking on Standing: A Critical Review

Erro

Bhatia

Cordivari

2014

Movement Disord Clin Pract

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Orthostatic tremor is a rare condition, though its exact prevalence is unknown, which is clinically characterized by a feeling of unsteadiness or being about to fall on standing and which disappears on walking, sitting, or lying down. It is generally accepted that classic orthostatic tremor manifests with a highfrequency tremor (>13 Hz) of the legs when standing. However, a number of patients initially reported as orthostatic tremor did not actually have such electrophysiological features. It is our experience that there is a clinical spectrum of different conditions presenting as shaking on standing, and this highlights the importance of the electrophysiology to aid the differential diagnosis of these disorders. Here, we provide a critical review of the clinical spectrum of shaking on standing, along with demonstrative electrophysiological recordings of some of these conditions.

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“…The possible role of a striatal dopamine transporter deficit in its genesis, as suggested by single-photon emission computed tomography studies, remains controversial. 4,5 Isolated OT is considered an idiopathic disorder, but in rare cases, OT has been observed in association with Parkinson disease, essential tremor, pontine lesions, cerebellar degeneration restless leg syndrome, or vascular or drug-induced parkinsonism ("OT plus"). 6 Although the age at onset of pure OT varies, in general it manifests earlier than OT plus, with a mean onset of the symptoms in the sixth decade.…”

mentioning

confidence: 99%