Intact parathyroid hormone measurement at 24 hours after thyroid surgery as predictor of parathyroid function at long term

Julián, María Teresa; Balibrea, José María; Granada, María Luisa; Moreno, Pau; Alastrué, Antonio; Puig-Domingo, Manel; Lucas, Anna

doi:10.1016/j.amjsurg.2013.01.038

Cited by 54 publications

(61 citation statements)

References 34 publications

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“…Postoperative hypoparathyroidism is currently the most common complication of total thyroidectomy1, and there is a need for a reliable tool that can accurately predict whether a patient will develop hypocalcaemia1, 14, 15. Currently available methods to evaluate parathyroid function are based on measurements of calcium16, 17 and PTH2, 6, 7, 18, 19, 20 levels at different time points after thyroidectomy.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

Fortuny

Belfontali

Sadowski

et al. 2016

British Journal of Surgery

148

130

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BackgroundPostoperative hypoparathyroidism remains the most common complication following thyroidectomy. The aim of this pilot study was to evaluate the use of intraoperative parathyroid gland angiography in predicting normal parathyroid gland function after thyroid surgery.MethodsAngiography with the fluorescent dye indocyanine green (ICG) was performed in patients undergoing total thyroidectomy, to visualize vascularization of identified parathyroid glands.ResultsSome 36 patients underwent ICG angiography during thyroidectomy. All patients received standard calcium and vitamin D supplementation. At least one well vascularized parathyroid gland was demonstrated by ICG angiography in 30 patients. All 30 patients had parathyroid hormone (PTH) levels in the normal range on postoperative day (POD) 1 and 10, and only one patient exhibited asymptomatic hypocalcaemia on POD 1. Mean(s.d.) PTH and calcium levels in these patients were 3·3(1·4) pmol/l and 2·27(0·10) mmol/l respectively on POD 1, and 4·0(1.6) pmol/l and 2·32(0·08) mmol/l on POD 10. Two of the six patients in whom no well vascularized parathyroid gland could be demonstrated developed transient hypoparathyroidism. None of the 36 patients presented symptomatic hypocalcaemia, and none received treatment for hypoparathyroidism.Conclusion PTH levels on POD 1 were normal in all patients who had at least one well vascularized parathyroid gland demonstrated during surgery by ICG angiography, and none required treatment for hypoparathyroidism.

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Section: Discussionmentioning

confidence: 99%

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

Fortuny

Belfontali

Sadowski

et al. 2016

British Journal of Surgery

148

130

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“…Anterior central neck compartment surgery is the leading cause of hypoparathyroidism [9,[21][22][23][24][25] and is one of the most common complications in patients undergoing thyroidectomy, with a prevalence of 10 to 46% [9,26,27].…”

Section: Post-surgical Hypoparathyroidism In Thyroid Surgerymentioning

confidence: 99%

“…Transient hypoparathyroidism is defined as the resolution of hypocalcemia, without treatment after the first 6-12 months postsurgery [9,11,12,24,26,28]. It has been described in approximately 10% of patients.…”

Section: Post-surgical Hypoparathyroidism In Thyroid Surgerymentioning

confidence: 99%

“…Decreased absolute values of iPTH within the first day postoperatively at 4hours < 10 pg/mL [49,50] or at 24 hours < 5.8 pg/mL, are correlated with postoperative hypocalcemia [12,24]. Accordingly, levels > 7 pg/mL [20], > 9.8 pg/mL [12], > 15 pg/mL [24,28,47], could exclude the development of persistent hypoparathyroidism.…”

Section: Post-surgical Hypoparathyroidism In Thyroid Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Hypocalcemia posthyroidectomy: prevention, diagnosis and management

Mg¹,

González-Devia²,

Fierro³

et al. 2018

J Transl Sci

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“…However, there is a need for reliable tools that can accurately predict whether a patient will develop hypocalcemia (5,23,24). The current techniques for evaluating parathyroid function are based on calcium (25,26) and PTH (6,27-31) measurements at various time points during or after thyroidectomy.…”

Section: Fluorescent Techniques With Icg In Neck Surgerymentioning

confidence: 99%

A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques

Sadowski¹,

Fortuny²,

Triponez³

2017

Gland Surg.

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Intact parathyroid hormone measurement at 24 hours after thyroid surgery as predictor of parathyroid function at long term

Cited by 54 publications

References 34 publications

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

Hypocalcemia posthyroidectomy: prevention, diagnosis and management

A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques

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