“…In line with this idea, TGF mice feature increased capillary basement membrane thickness and endothelial cell degeneration (Wyss-Coray et al, 2000), resting hypoperfusion throughout the brain (Gaertner et al, 2005), impaired neurovascular coupling during whisker stimulation (Nicolakakis et al, 2011) (Table 1), and reduced basal CGU (Galea et al, 2006). The hemodynamic and metabolic changes may be related to glial activation in the TGF mouse brain (Wyss-Coray et al, 1995;Lacombe et al, 2004;Nicolakakis et al, 2011), but are mainly believed to have a vascular etiology, in view of the unaltered neuronal indices in old transgenic animals relative to age-matched WT littermates (18 to 22 months old). At this age, TGF mice featured preserved cortical cholinergic innervation, intact CGU increase during whisker stimulation, as measured by 18 F-fluorodeoxyglucose-positron emission tomography, and preserved spatial memory in the Morris water maze (Nicolakakis et al, 2011).…”