Intact Mammalian Cell Function on Semiconductor Nanowire Arrays: New Perspectives for Cell‐Based Biosensing

Berthing, Trine; Bonde, Sara; Sørensen, C. B.; Utko, Pawel; Nygård, Jesper; Martinez, Karen L.

doi:10.1002/smll.201001642

Cited by 83 publications

(91 citation statements)

References 39 publications

(60 reference statements)

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“…Several studies have examined the interactions of NWs with cells, mainly using confocal microscopy. NWs have been indirectly visualized as dark spots due to spatial exclusion within labeled cells 17,18 or were directly labeled with fluorescent organic dyes. 19−21 To circumvent bleaching issues associated with these methods, it has been recently proposed 22 to use the intrinsic photoluminescence of NW heterostructures as contrast method for their visualization in biological systems.…”

mentioning

confidence: 99%

Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature

et al. 2017

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Nanowires hold great promise as tools for probing and interacting with various molecular and biological systems. Their unique geometrical properties (typically <100 nm in diameter and a few micrometers in length) enable minimally invasive interactions with living cells, so that electrical signals or forces can be monitored. All such experiments require in situ high-resolution imaging to provide context. While there is a clear need to extend visualization capabilities to the nanoscale, no suitable super-resolution far-field photoluminescence microscopy of extended semiconductor emitters has been described. Here, we report that ground state depletion (GSD) nanoscopy resolves heterostructured semiconductor nanowires formed by alternating GaP/GaInP segments (“barcodes”) at a 5-fold resolution enhancement over confocal imaging. We quantify the resolution and contrast dependence on the dimensions of GaInP photoluminescence segments and illustrate the effects by imaging different nanowire barcode geometries. The far-red excitation wavelength (∼700 nm) and low excitation power (∼3 mW) make GSD nanoscopy attractive for imaging semiconductor structures in biological applications.

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confidence: 99%

Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature

et al. 2017

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“…Nanostructured electrodes provide additional advantages such as improved electrical properties (Keefer et al 2008;Cellot et al 2009;Martin et al 2010;Ansaldo et al 2011;Duan et al 2012), a shorter cell-to-electrode distance Duan et al 2012;Xie et al 2012), and better spatial resolution. They also have a potential for less tissue damage (Almquist and Melosh 2010;Martin et al 2010;Tian et al 2010;Duan et al 2012), better biocompatibility (Hallstrom et al 2007;Kim et al 2007;Martin et al 2010;Berthing et al 2011) and new functionalities, such as selective guidance of neuronal fibers (Hallstrom et al 2009). Importantly, recordings of cell signals with different nanowire-based electrodes have been achieved in vitro (Kotov et al 2009;Tian et al 2010;Timko et al 2010;Brueggemann et al 2011;Dvir et al 2011;Duan et al 2012;Robinson et al 2012;Xie et al 2012), thus demonstrating that epitaxially grown wires of small diameter may provide a minimally invasive tissue penetration Takei et al 2010;Tian et al 2010;Duan et al 2012;Xie et al 2012).…”

Section: Nanowires-based Neural Devicesmentioning

confidence: 98%

Uncovering Cortical Modularity by Nanotechnology

Enăchescu

Vidu

Opriş

2015

Recent Advances on the Modular Organization of the Cortex

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Cortical modularity and nanotechnology might look like a strange pair of concepts taken together, but nevertheless they seem very much suited for each other. Indeed, cortical modularity is a fundamental microanatomic feature of the brain while nanotechnology with its nanometric precision provides nanoscale structures, namely nanowires and carbon nanotubes capable of interacting with the brain at the genetic, molecular, and microcircuit level. Research in neuroscience is essentially a combination of many interdisciplinary sciences where nanoscience and nanotechnology plays a pivotal role. In this chapter we examine carbon nanotubes (CNTs) and nanowires (NWs), and their potential to uncover the function of cortical microcircuits, as well as novel applications for diagnosis and treatment of brain diseases. For example, the simultaneous recording from cortical minicolumns with multi-electrode arrays (MEAs) consisting of CNTs or NWs is emerging for developing cognitive prostheses for a broad range of neurological and psychiatric dysfunctions.

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“…Nanostructured electrodes provide additional advantages such as improved electrical properties (Keefer et al, 2008; Cellot et al, 2009; Martin et al, 2010; Ansaldo et al, 2011; Duan et al, 2012), shorter cell-to-electrode distance (Tian et al, 2010; Duan et al, 2012; Xie et al, 2012), as well as a better spatial resolution. They also have a potential for less tissue damage (Almquist and Melosh, 2010; Martin et al, 2010; Tian et al, 2010; Duan et al, 2012), better biocompatibility (Hallstrom et al, 2007; Kim et al, 2007; Martin et al, 2010; Berthing et al, 2011) and new functionalities, such as selective guidance of neuronal fibers (Hallstrom et al, 2009). Importantly, recent cell signal recordings with different nanowire-based electrodes have been achieved in vitro (Tian et al, 2010; Timko et al, 2010; Brueggemann et al, 2011; Dvir et al, 2011; Duan et al, 2012; Robinson et al, 2012; Xie et al, 2012), demonstrating the epitaxially grown wires of small diameter may provide minimally invasive tissue penetration (Kawano et al, 2010; Takei et al, 2010; Tian et al, 2010; Duan et al, 2012; Xie et al, 2012).…”

Section: Nanomaterialsmentioning

confidence: 99%

Nanostructures: a platform for brain repair and augmentation

Vidu

Rahman

Mahmoudi

et al. 2014

Front. Syst. Neurosci.

104

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Nanoscale structures have been at the core of research efforts dealing with integration of nanotechnology into novel electronic devices for the last decade. Because the size of nanomaterials is of the same order of magnitude as biomolecules, these materials are valuable tools for nanoscale manipulation in a broad range of neurobiological systems. For instance, the unique electrical and optical properties of nanowires, nanotubes, and nanocables with vertical orientation, assembled in nanoscale arrays, have been used in many device applications such as sensors that hold the potential to augment brain functions. However, the challenge in creating nanowires/nanotubes or nanocables array-based sensors lies in making individual electrical connections fitting both the features of the brain and of the nanostructures. This review discusses two of the most important applications of nanostructures in neuroscience. First, the current approaches to create nanowires and nanocable structures are reviewed to critically evaluate their potential for developing unique nanostructure based sensors to improve recording and device performance to reduce noise and the detrimental effect of the interface on the tissue. Second, the implementation of nanomaterials in neurobiological and medical applications will be considered from the brain augmentation perspective. Novel applications for diagnosis and treatment of brain diseases such as multiple sclerosis, meningitis, stroke, epilepsy, Alzheimer's disease, schizophrenia, and autism will be considered. Because the blood brain barrier (BBB) has a defensive mechanism in preventing nanomaterials arrival to the brain, various strategies to help them to pass through the BBB will be discussed. Finally, the implementation of nanomaterials in neurobiological applications is addressed from the brain repair/augmentation perspective. These nanostructures at the interface between nanotechnology and neuroscience will play a pivotal role not only in addressing the multitude of brain disorders but also to repair or augment brain functions.

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Intact Mammalian Cell Function on Semiconductor Nanowire Arrays: New Perspectives for Cell‐Based Biosensing

Cited by 83 publications

References 39 publications

Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature

Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature

Uncovering Cortical Modularity by Nanotechnology

Nanostructures: a platform for brain repair and augmentation

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