Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Woolley, Andrew J.; Desai, Himanshi A.; Gaire, Janak; Ready, Andrew; Otto, Kevin J.

doi:10.3791/50126

Cited by 8 publications

(5 citation statements)

References 22 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These micromachined silicon constructs are likely to cause a frustrated immune response, as they do not move freely with the pulsatile motion of the cortex. As a result, a softer CP is less likely to improve the tissue interface, which is largely dominated by the mechanical mismatch of the array …”

Section: Neural Applicationsmentioning

confidence: 99%

Conducting Polymers for Neural Prosthetic and Neural Interface Applications

2015

View full text Add to dashboard Cite

Neural interfacing devices are an artificial mechanism for restoring or supplementing the function of the nervous system lost as a result of injury or disease. Conducting polymers (CPs) are gaining significant attention due to their capacity to meet the performance criteria of a number of neuronal therapies including recording and stimulating neural activity, the regeneration of neural tissue and the delivery of bioactive molecules for mediating device-tissue interactions. CPs form a flexible platform technology that enables the development of tailored materials for a range of neuronal diagnostic and treatment therapies. In this review the application of CPs for neural prostheses and other neural interfacing devices are discussed, with a specific focus on neural recording, neural stimulation, neural regeneration, and therapeutic drug delivery.

show abstract

Section: Neural Applicationsmentioning

confidence: 99%

Conducting Polymers for Neural Prosthetic and Neural Interface Applications

2015

View full text Add to dashboard Cite

show abstract

“…The ability to image detailed cellular and sub-cellular anatomy in thick sections that contain devices, or in fully intact biological systems (Woolley et al, 2011, 2013a, 2013b, 2013c) are major technological improvements. The ability to image device-tissue interactions in vivo provides another step forward, allowing longitudinal observations (Schendel et al, 2013).…”

Section: Summary: Challenges and Future Directionsmentioning

confidence: 99%

Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means

Sommakia¹,

Lee²,

Gaire³

et al. 2014

Current Opinion in Solid State and Materials Science

Self Cite

View full text Add to dashboard Cite

Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.

show abstract

“…Niemczyk (2011) proposed to combine intelligent materials and textile products that have shape memory function through certain methods so that under the external conditions of PH, light and mechanical force, the function of shape memory is equipped, which is applied to “lazy shirt” designed by Corpo Nove. Woolley et al . (2013) researched on micro-wearable devices for brain implantation, aiming at realizing seamless docking between intelligent products and human body in the future.…”

Section: Introductionmentioning

confidence: 99%

R&D mode of intelligent safety clothing under micro-interaction concept

Lei

Liu

Xue

et al. 2019

IJCST

View full text Add to dashboard Cite

Purpose With the application and development of intelligent clothing and wearable technology, the term “micro-interaction” has gradually entered people’s lives. The paper aims to discuss this issue. Design/methodology/approach The paper takes the concept of “micro-interaction” as the design principle, starting from the consumer demand, combing the realization mode of the intelligent safety clothing in recent years, and finds out the existing problems in the design of the intelligent safety clothing. Findings Under the concept of micro-interaction, a new theoretical model has been proposed to study intelligent safety clothing. Finally, the paper also emphasizes the importance of the industrialization of the proposed model. Originality/value The paper proposes a new research and development mode for intelligent clothing in safety protection area which is a pioneering study and can be valuable for safety clothing manufacturers to produce more functional and attractive products.

show abstract

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Cited by 8 publications

References 22 publications

Conducting Polymers for Neural Prosthetic and Neural Interface Applications

Conducting Polymers for Neural Prosthetic and Neural Interface Applications

Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means

R&D mode of intelligent safety clothing under micro-interaction concept

Contact Info

Product

Resources

About