2020
DOI: 10.1016/j.jalz.2019.08.200
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Intact global cognitive and olfactory ability predicts lack of transition to dementia

Abstract: Introduction:Odor identification deficits characterize Alzheimer's disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. Methods:In an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analyzed. Results: In covariat… Show more

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Cited by 28 publications
(33 citation statements)
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“…Most likely, this is because many aging persons have an olfactory impairment for reasons that are unrelated to dementia and which were described earlier. Thus, Devanand et al. (2020) recently suggested, based on empirical results from a large-scale longitudinal study, that olfaction should be used as a screening tool, such that aging persons with a high olfactory performance can be regarded as being at very low risk for dementia in the coming years, whereas a poor olfactory performance is less informative in terms of dementia risk (because olfactory impairment has many other potential causes), and further investigation is always needed before an increased risk of dementia can be established.…”
Section: Cognition and Dementiamentioning
confidence: 99%
“…Most likely, this is because many aging persons have an olfactory impairment for reasons that are unrelated to dementia and which were described earlier. Thus, Devanand et al. (2020) recently suggested, based on empirical results from a large-scale longitudinal study, that olfaction should be used as a screening tool, such that aging persons with a high olfactory performance can be regarded as being at very low risk for dementia in the coming years, whereas a poor olfactory performance is less informative in terms of dementia risk (because olfactory impairment has many other potential causes), and further investigation is always needed before an increased risk of dementia can be established.…”
Section: Cognition and Dementiamentioning
confidence: 99%
“…In addition, in community elderly individuals and patients with amnestic mild cognitive impairment, OI dysfunction predicts faster cognitive decline and a higher rate of conversion to AD 19 , in particular when combined with neuropsychological assessments and neuroimaging evaluations 20 . Conversely, intact global cognition and OI predicted a lack of transition to dementia in older adults 21 .…”
Section: Introductionmentioning
confidence: 95%
“…In the early pathological stages of Alzheimer's disease (AD), neurofibrillary tangles develop in the olfactory bulb and extend to olfactory projection areas in limbic regions, including the piriform cortex, amygdala, entorhinal cortex, hippocampus, and orbitofrontal cortex [1][2][3][4][5]. Clinically, this manifests as impairment in performance on tests of olfaction, particularly standardized odor identification tests [6,7]. Odor identification impairment demonstrates predictive utility that may be superior to episodic verbal memory impairment for the transition from cognitively normal to mild cognitive impairment (MCI), and shows comparable predictive accuracy for the transition from MCI to AD [6,[8][9][10].…”
Section: Introductionmentioning
confidence: 99%