Intact differentiation of responses to socially-relevant emotional stimuli across psychotic disorders: An event-related potential (ERP) study

Clayson, Peter E.; Wynn, Jonathan K.; Jimenez, Amy M.; Reavis, Eric A.; Lee, Jung‐Hee; Green, Michael F.; Horan, William P.

doi:10.1016/j.schres.2022.06.033

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…Comparator groups were as follows: 87 schizophrenia vs HC, 18 PDPP/CHR vs HC, and 6 schizophrenia vs PDPP/CHR vs HC. For 25 studies, data were obtained from authors. We used the SMD as reported in Cohen and Minor for 5 studies and as reported in Moberg and colleagues for 2 studies .…”

Section: Resultsmentioning

confidence: 99%

Emotional Experience of People With Schizophrenia and People at Risk for Psychosis

Riehle,

Straková,

Lincoln

2024

JAMA Psychiatry

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ImportancePsychotic symptoms are associated with subjective reports of aberrant emotion, such as excessive fear or anhedonia, but whether these aberrations reflect aberrant emotional experience of normative stimuli is uncertain both for individuals with schizophrenia and those at risk for psychosis.ObjectiveTo provide a meta-analysis of study samples of emotional experience in individuals with schizophrenia and those at risk for psychosis as assessed in laboratory-based emotion-induction studies.Data SourcesMEDLINE and PsycINFO databases were searched for articles published from January 1986 and Google Scholar citations of a relevant earlier meta-analysis until August 2022. Reference lists were manually searched for additional studies.Study SelectionIncluded studies measured positive or negative emotional experience in response to standardized emotionally evocative stimuli and compared participants diagnosed with schizophrenia or participants at risk for psychosis with healthy controls.Data Extraction and SynthesisThe meta-analysis was registered with PROSPERO and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. Data were extracted by 2 independent coders, and random-effects analyses were conducted.Main Outcomes and MeasuresOutcomes were 3 scales of emotional experience (unipolar positive emotion, unipolar negative emotion, bipolar valence), analyzed separately for pleasant, neutral, and unpleasant stimuli. A meta-analysis was conducted for differences between the 2 clinical groups combined and controls. Subgroup differences (schizophrenia vs at risk) and the influence of several other variables were tested in moderator analyses.ResultsThis systematic review and meta-analysis included data from 111 studies and 6913 participants (schizophrenia: 2848 [41.2%]; at risk: 877 [12.7%]; healthy controls: 3188 [46.1%]). Compared with controls, people with schizophrenia and those at risk for psychosis experienced pleasant stimuli as less positive (unipolar positive: standardized mean difference [SMD] Hedges g = −0.19; P =.001; bipolar valence: SMD Hedges g = −0.28; P &lt;.001) and more negative (Hedges g = 0.52; P &lt;.001), neutral stimuli as more negative (Hedges g = 0.55; P &lt;.001), and unpleasant stimuli as both more positive (unipolar positive: SMD Hedges g = 0.23; P =.005; bipolar valence: Hedges g = 0.12; P =.01) and more negative (Hedges g = 0.22; P &lt;.001). Moderator analyses indicated a less aberrant emotional experience for odors than for visual stimuli (unipolar negative, pleasant z score = −2.97; P =.003; unipolar negative, neutral z score = −2.70; P =.007), an association between higher negative symptoms and diminished positive emotion for pleasant stimuli in schizophrenia (z score = −2.98; P =.003), and that subgroup differences were limited to neutral stimuli.Conclusions and RelevanceResults suggest a pattern of aberrant emotional experience of normative stimuli in schizophrenia and that this already was observable before disorder onset. In particular, the aberrant experience of pleasant stimuli needs to be considered as an intervention target.

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