1997
DOI: 10.1152/ajpendo.1997.273.6.e1090
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Insulinotropic action of α-d-glucose pentaacetate: functional aspects

Abstract: The functional determinants of the insulinotropic action of α-d-glucose pentaacetate were investigated in rat pancreatic islets. The ester mimicked the effect of nutrient secretagogues by recruiting individual B cells into an active secretory state, stimulating proinsulin biosynthesis, inhibiting86Rb outflow, and augmenting45Ca efflux from prelabeled islets. The secretory response to the ester was suppressed in the absence of Ca2+ and potentiated by theophylline or cytochalasin B. The generation of acetate fro… Show more

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Cited by 7 publications
(6 citation statements)
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“…The pentaacetate ester of ␤-Lglucose (1.7 mM), however, inhibited (P Ͻ 0.02 or less) the tritiation of islet peptides in islets exposed to either 4.2 mM D-glucose or 10.0 mM L-leucine. This contrasts with the fact that the insulinotropic action of ␤-Lglucose pentaacetate is more marked in the presence of D-glucose or L-leucine than in the absence of exogenous nutrient (21).…”
Section: Phosphorylation Of L-glucosementioning
confidence: 71%
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“…The pentaacetate ester of ␤-Lglucose (1.7 mM), however, inhibited (P Ͻ 0.02 or less) the tritiation of islet peptides in islets exposed to either 4.2 mM D-glucose or 10.0 mM L-leucine. This contrasts with the fact that the insulinotropic action of ␤-Lglucose pentaacetate is more marked in the presence of D-glucose or L-leucine than in the absence of exogenous nutrient (21).…”
Section: Phosphorylation Of L-glucosementioning
confidence: 71%
“…Secretory data. The insulinotropic action of ␤-Lglucose pentaacetate was previously explored in islets incubated either in the absence of any exogenous nutrient (21) or in the presence of 8.3 mM D-glucose, 10.0 mM L-leucine (21), or 10.0 mM succinic acid dimethyl ester (18). In the absence of another exogenous nutrient or at a noninsulinotropic concentration of D-glucose (4.0 mM), the increase in insulin output caused by ␤-L-glucose pentaacetate is quite modest and, on occasion, fails to achieve statistical significance.…”
Section: Phosphorylation Of L-glucosementioning
confidence: 99%
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“…In islets from spontaneously diabetic Goto rats, the glucose ester enhances to a greater relative extent the secretory response to L-leucine, as compared to islets from control rats (8). Last, at variance with the hypoglycaemic sulfonylureas and meglitinide analogs currently used as antidiabetic agents, glucose pentaacetate stimulates biosynthetic activity in isolated rat pancreatic islets (9,10). Interestingly, the ester was also found to stimulate both insulin synthesis and release in pancreatic islets from human subjects (11).…”
Section: Eo Balassementioning
confidence: 99%