Insulinoma in Pregnancy

Besemer, Britta; Müssig, Karsten

doi:10.1055/s-0029-1202272

Cited by 20 publications

(53 citation statements)

References 32 publications

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“…Insulinomas are most often benign and solitary tumors (80%), which may be associated with MEN-1 in 7.6% of the cases [2,4]. The average age of diagnosis is 47 years with a slight predominance in women (59%).…”

Section: Discussionmentioning

confidence: 99%

“…The usual presentation of an insulinoma consists of fasting and/ or postabsorptive hypoglycemia-related symptoms, comprising both neurogenic and adrenergic manifestations [2][3][4]6]. Weight gain is described in 18% of patients and the average duration of symptoms was 1.5 years [8].…”

Section: Discussionmentioning

confidence: 99%

“…These neuroendocrine tumors represent an uncommon, otherwise usually curable cause of hypoglycemia [1]. The estimated incidence is approximately four cases per million [2][3][4][5][6]. The occurrence of an insulinoma during pregnancy or in the postpartum period is even rarer and may be life threatening.…”

Section: Introductionmentioning

confidence: 99%

“…The occurrence of an insulinoma during pregnancy or in the postpartum period is even rarer and may be life threatening. Since 1939, only 27 cases of insulinomas associated with pregnancy have been reported [4].…”

Section: Introductionmentioning

confidence: 99%

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Insulinoma diagnosed in the postpartum: clinical and immunohistochemical features

Queiróz

Nazareno

Miranda

et al. 2012

Gynecological Endocrinology

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Insulinomas are rare pancreatic β-cell tumors with an estimated incidence of 1:250.000 persons/year. We present a novel case of insulinoma manifesting immediately after childbirth. Eight days after delivery, a 21-year-old, previously healthy woman presented paresthesia in hands, upper and lower limbs muscle weakness with difficult walking, which worsened during breastfeeding sessions. Laboratory tests showed blood glucose levels between 37 and 55 mg/dL with inappropriately normal insulin levels (7.78 μUI/mL; normal range: 5-29). An abdominal computed tomography showed a nodular lesion measuring 2 cm at the head of the pancreas. Tumor enucleation resulted in complete resolution of hypoglycemia. Histopathological and immunohistochemical analysis were consistent with an insulinoma. About 27 cases of insulinoma associated with pregnancy have been reported to date, mostly diagnosed before the 16th week. The beginning of symptoms soon after delivery is less common. Understanding the interactions between pancreatic β-cell function and all the physiological metabolic and hormonal adaptations associated with gestation is essential for the adequate management of hypoglycemic disorders in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Insulinoma diagnosed in the postpartum: clinical and immunohistochemical features

Queiróz

Nazareno

Miranda

et al. 2012

Gynecological Endocrinology

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“…Auch kann es infolge von Heißhungerattacken zu einer erheblichen Gewichtszunahme kommen [10]. In seltenen Fäl-len ist die klinische Symptomatik eines Insulinoms während einer Schwangerschaft [7] oder bei präexistentem Diabetes mellitus [16] aufgrund der bestehenden Insulinresistenz abgemildert oder auch ganz maskiert.…”

Section: Insulinomunclassified

Diagnostik und Therapie bei funktionell aktiven pankreatischen neuroendokrinen Tumoren

Müssig¹,

Dudziak²,

Horger³

et al. 2011

Dtsch med Wochenschr

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Pancreatic neuroendocrine tumours (PNET) are rare entities with an annual incidence of < 100,000. About 1 - 2 % of pancreatic neoplasias are neuroendocrine tumours. About one third of these tumours secrete biologically active substances that lead to development of specific clinical syndromes. PNET may occur sporadically or in association with hereditary syndromes, such as multiple endocrine neoplasia type 1 (MEN1). Among the functional PNET, insulinomas and gastrinomas are the most common entities. In contrast, vasoactive intetinale peptide (VIP)-secreting tumours, glucagonomas, serotonin-secreting carcinoid tumors, and tumours with secretion of ectopic hormones, such as calcitonin, are extremely rare. Once diagnosis has been established on the basis of clinical and laboratory findings, localization of the source of pathologic hormone secretion is warranted. Imaging methods frequently used for localization of PNET comprise anatomical imaging modalities, computed tomography, and magnetic resonance imaging, endoscopic ultrasound, selective arterial catheterization with hepatic venous sampling, DTPA-octreotid scintigraphy and DOTA-D-Phe(1)-Tyr(3)-octreotid positron emission tomography. Therapy is based on the specific tumour entity and the extent of the disease. In the majority of patients, even in the case of malignant disease, a surgical approach is warranted, eventually combined with a medical treatment.

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A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy

Abe

Takeda

Takiyama

et al. 2021

Clinical Case Reports

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Insulinoma in Pregnancy

Cited by 20 publications

References 32 publications

Insulinoma diagnosed in the postpartum: clinical and immunohistochemical features

Insulinoma diagnosed in the postpartum: clinical and immunohistochemical features

Diagnostik und Therapie bei funktionell aktiven pankreatischen neuroendokrinen Tumoren

A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy

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