Insulino-mimetic and anti-diabetic effects of zinc

Vardatsikos, George; Pandey, Nihar R.; Srivastava, Ashok K.

doi:10.1016/j.jinorgbio.2012.11.006

Cited by 93 publications

(57 citation statements)

References 169 publications

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“…Correspondingly, several studies have assessed the effect of a dietary zinc supplementation in T1D and T2D patients (for review, [16]). The effects on the diabetic phenotype vary but globally, scientists observed beneficial effects especially in decreasing HbA1c levels and cholesterol.…”

Section: Zinc and The Diabetic Patientmentioning

confidence: 99%

Zinc and diabetes

Chabosseau

Rutter

2016

Archives of Biochemistry and Biophysics

148

104

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Zn 2+ ions are essential for the normal processing and storage of insulin and altered pancreatic insulin content is associated with all forms of diabetes mellitus. Work of the past decade has identified variants in the human SLC30A8 gene, encoding the zinc transporter ZnT8 which is expressed highly selectively on the secretory granule of pancreatic islet β and α cells, as affecting the risk of Type 2 Diabetes. Here, we review the regulation and roles of Zn 2+ ions in islet cells, the mechanisms through which SLC30A8 variants might affect glucose homeostasis and diabetes risk, and the novel technologies including recombinant targeted zinc probes and knockout mice which have been developed to explore these questions. Abbreviation ISG: Insulin Secreting Granules; T2D: Type 2 Diabetes; T1D: Type 1 Diabetes; 2 Diabetes mellitus is a common metabolic disease, affecting approximately 9% of the adult population worldwide. It is characterized by high circulating glucose levels over a prolonged period of time which leads to long-term health complications [1]. Type 1 Diabetes (T1D) involves the autoimmune destruction of insulin-secreting β cells while Type 2 Diabetes (T2D) is linked to both a decrease of insulin release and deficient hormone action on targeted organs [2].The links among Zn 2+ , diabetes and insulin were established in the 1930s, a decade after the discovery of the hormone, when a study showed crystallized insulin contains Zn 2+ and that Zn 2+ , along with other metal ions, could reversibly trigger insulin crystallization [3]. Zinc was later demonstrated to prolong insulin action when co-injected with the hormone [4].These early studies, as well as much more recent findings showing association between T2D risk and the inheritance of gene variants encoding a critical β cell Zn 2+ transporter, ZnT8[5] have generated considerable interest in the role of Zn 2+ in diabetes aetiology and as a possible therapeutic target [6]. Zinc and the diabetic patientScott and Fisher were the first to report a direct link between zinc and diabetes in patients.While assessing the insulin content in the pancreas of diabetic patients compared to nondiabetic cadavers, they showed that in the former group zinc content was reduced by 75 % [7].Epidemiological studies also demonstrated that diabetes and whole body zinc status are associated [8][9][10][11]. In T1D and T2D patients, serum zinc levels are significantly decreased [9][10][11], this being associated with an increased zinc urinary loss [8].Zinc may have important anti-oxidant properties, as it acts as a cofactor of the superoxide dismutase enzyme which regulates the detoxification of reactive oxygen species, regulating the expression and protecting against the oxidative stress induced by chronic hyperglycaemia (for review, [12]). Furthermore, zinc inhibits alpha-ketoglutarate-dependent mitochondrial respiration suggesting that Zn 2+ can interfere with mitochondrial antioxidant production and may also stimulate production of reactive oxygen [13].Zinc supplementation h...

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Section: Zinc and The Diabetic Patientmentioning

confidence: 99%

Zinc and diabetes

Chabosseau

Rutter

2016

Archives of Biochemistry and Biophysics

148

104

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“…Zinc (Zn) is a trace element and the most abundantly found mineral in all human tissues and tissue fluids, after iron (7). A wide range of biological activities such as cell division (8), immune responses regulation (9,10), epithelial cell integrity (11), and the proper function of more than 300 enzymes from all enzyme families (12,13) are tightly correlated with zinc.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

Nazarizadeh

Asri-Rezaie

2015

AAPS PharmSciTech

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Abstract. In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO 4 ) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO 4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO 4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.

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“…Previous studies evaluated ZM effects on IMF thickness and backfat thickness in steers, but not the interaction ZH )ZM (Greene et al 1988;Malcom-Callis et al 2000;Spears and Kegley 2002). Zinc has a lipogenic effect (Tang and Shay 2001;Park et al 2003;Vardatsikos et al 2013) caused by inhibition of lipolytic substances (May and Contoreggi 1982;Oh and Choi 2004) and by changing expression of transcript factors and genes responsible for triglycerides and lipoproteins synthesis (Oh and Choi 2004). In addition, ZH inhibits the biosynthesis of de novo fatty acids and stimulates the hydrolysis of triacylglycerol (Oscar 1995;Johnson et al 2014).…”

Section: Carcass Characteristicsmentioning

confidence: 99%

Effects of zilpaterol hydrochloride and zinc methionine on growth performance and carcass characteristics of beef bulls

Rodríguez-GaxiolaMiguel

Domínguez-VaraIgnacio

Barajas-CruzRubén

et al. 2015

Can. J. Anim. Sci.

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. 2015. Effects of zilpaterol hydrochloride and zinc methionine on growth performance and carcass characteristics of beef bulls. Can. J. Anim. Sci. 95: 609Á615. Sixty beef bulls with a body weight (BW) of 314.79 16.2 kg were used to evaluate the effects of zilpaterol hydrochloride (ZH) and zinc methionine (ZM) on growth performance and carcass characteristics. The experimental design was a randomized complete block, with a factorial 2 )2 arrangement of treatments (ZH: 0 and 0.15 mg kg(1 BW; ZM: 0 and 80 mg kg (1 dry matter). The ZH increased (P B0.05) the final BW, average daily gain, feed conversion, carcass yield and longissimus dorsi area. Bulls fed ZH plus ZM had less (PB0.01) backfat thickness and intramuscular fat (IMF) compared with those fed ZH or ZM alone. The ZH increased (PB0.02) the meat crude protein content and cooking loss. It is therefore concluded that ZH increases growth performance, carcass yield, longissimus dorsi area, and meat crude protein. The interaction of ZM and ZH did not present additional advantages. The reason for the reduction in backfat thickness and IMF by ZH plus ZM is unclear, and implies that our knowledge of b-agonistic adrenergic substances and their interactions with minerals is incomplete. (1 BW; ZM : 0 et 80 mg kg (1 matie`res se`ches Á DM Á « dry matter »). Le ZH a augmente´(P B0,05) le BW final, le gain moyen quotidien, l'indice de consommation, le rendement de carcasse et l'aire du muscle longissimus dorsi. Les taureaux nourris de ZH et de ZM avaient une plus faible (P B0,01) e´paisseur de gras dorsal et de gras intramusculaire (IMF Á « intramuscular fat ») par rapport aux taureaux nourris de ZH seulement ou ZM seulement. Le ZH a augmente´(PB0,02) la teneur en prote´ines brutes de la viande et les pertes a`la cuisson. Par conse´quent, on peut conclure que le ZH augmente la performance de croissance, le rendement de la carcasse, l'aire du muscle longissimus dorsi et le taux de prote´ines brutes de la viande. L'interaction de ZM et de ZH ne pre´sente pas d'avantages supple´mentaires. La re´duction de e´paisseur de gras dorsal et du IMF par ZM et ZH ensemble demeure incomprise et souligne que nos connaissances des substances b-agonistes adre´nergiques et leurs interactions avec les mine´raux sont encore incomple`tes.

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Insulino-mimetic and anti-diabetic effects of zinc

Cited by 93 publications

References 169 publications

Zinc and diabetes

Zinc and diabetes

Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

Effects of zilpaterol hydrochloride and zinc methionine on growth performance and carcass characteristics of beef bulls

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