Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by body mass index, waist-to-height ratio, C-reactive protein and Creatinine

Vela, Driton; Leshoski, Jovica; Vela, Zana; Jakupaj, Muharrem; Mladenov, Mitko; Sopi, Ramadan

doi:10.1186/s12902-017-0204-4

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…Individuals with T2DM had elevated hepcidin, which was further elevated with concurrent obesity, and also had elevated hepcidin:ferritin ratio [ 92 ]. In agreement with this, one group recruited cohorts of individuals without diabetes, with prediabetes or with T2DM on insulin [ 93 ]. The group with T2DM on insulin had higher hepcidin than controls, whilst paradoxically the group with prediabetes had lower hepcidin levels than the control group.…”

Section: Iron Stores Iron Status and Type 2 Diabetesmentioning

confidence: 99%

Iron, glucose and fat metabolism and obesity: an intertwined relationship

et al. 2023

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A bidirectional relationship exists between adipose tissue metabolism and iron regulation. Total body fat, fat distribution and exercise influence iron status and components of the iron-regulatory pathway, including hepcidin and erythroferrone. Conversely, whole body and tissue iron stores associate with fat mass and distribution and glucose and lipid metabolism in adipose tissue, liver, and muscle. Manipulation of the iron-regulatory proteins erythroferrone and erythropoietin affects glucose and lipid metabolism. Several lines of evidence suggest that iron accumulation and metabolism may play a role in the development of metabolic diseases including obesity, type 2 diabetes, hyperlipidaemia and non-alcoholic fatty liver disease. In this review we summarise the current understanding of the relationship between iron homoeostasis and metabolic disease.

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Section: Iron Stores Iron Status and Type 2 Diabetesmentioning

confidence: 99%

Iron, glucose and fat metabolism and obesity: an intertwined relationship

et al. 2023

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“…Thus, YKL-40 has the potential to become a biomarker for DCM, but also to prevent or even to treat it once established. However, the fact that insulin treatment does not correct YKL-40 serum levels in persons with type 2 diabetes mellitus [59] casts a doubt on its feasibility as a suitable biomarker for DCM.…”

Section: Soluble St2 (Suppression Of Tumorigenicity 2) Is a Cardiac Biomarker Cleared By The Food Andmentioning

confidence: 99%

Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?

Palomer

Pizarro-Delgado

Vázquez‐Carrera

2018

Trends in Pharmacological Sciences

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“…The results of study [8] revealed an increase in the average value of serum creatinine in patients suffering from diabetic nephropathy, in relation to the level of urea in the blood. The results of study [9] showed an increase in the average concentration of blood urea in diabetic patients compared to the healthy group, and the results showed Study [10] found a decrease in the concentration of total protein in the serum of patients with diabetic nephropathy.…”

Section: Related Workmentioning

confidence: 89%

Assessment the Role of Kidney Function and Total Proteins in Patients with Diabetic Nephropathy in Kirkuk City/ Iraq

Hamad,

Abdulrahman

2024

JPDMHD

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The current study aims to determine the levels of creatinine, urea, glomerular filtration rate eGFR and total proteins in patients with diabetic nephropathy, the experiment was conducted for the period from the beginning of July 2023 until the end of October 2023 Blood samples were collected from patients visiting Kirkuk General Hospital and specialized medical clinics in the city of Kirkuk, and included (70) male patients with diabetic nephropathy at the ages of (35-75) years and an average weight of (79) kg, as well as About (20) healthy people with the same average age and weight of patients and the study samples were distributed as follows: The first group of control group included (20) healthy males and the second group of patients group was distributed into four groups according to age groups age group (35 - 45) years and included 16 patients, age group (46 - 55) years and included 17 patients, age group (56 - 65) years and included 20 patients age group (66 - 75) years and included 17 patients. The study's findings indicated a noteworthy rise (P ≤ 0.05) in the levels of creatinine and urea and a significant decrease in the rate of glomerular filtration and total proteins in patients with diabetes compared to the control group, either by age groups, the results showed no significant differences in the concentration of creatinine and urea in patients with diabetes, while the rate of glomerular filtration and total proteins by age groups showed significant differences in patients with diabetes, as the first category showed a significant increase Compared to the rest of the categories.

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Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by body mass index, waist-to-height ratio, C-reactive protein and Creatinine

Cited by 4 publications

References 39 publications

Iron, glucose and fat metabolism and obesity: an intertwined relationship

Iron, glucose and fat metabolism and obesity: an intertwined relationship

Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?

Assessment the Role of Kidney Function and Total Proteins in Patients with Diabetic Nephropathy in Kirkuk City/ Iraq

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