Insulin supplemented with phenolic fraction concentrates displays anxiolytic and antidepressant-like properties with reductions of oxidative brain damage in chronically stressed diabetic rats

Bikri, Samir; Talhaoui, Abdeljalil; Fath, Nada; Hsaini, Asmae; Benmhammed, Hajar; Ahami, Ahmed Omar Touhami; Aboussaleh, Youssef

doi:10.34172/jhp.2022.65

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…Additionally, it is clear that numerous studies have been undertaken on the topic of "ROS inhibition" prevention. This is consistent with the strong nature of STZ as an extremely potent producer of "oxidants" free radicals (Bikri et al, 2022). This study also demonstrated the evolution of type 1 and type 2 diabetes biomarker research.…”

Section: Co-occurrence Visualizationsupporting

confidence: 85%

Bibliometric Analysis: the Use of Streptozotocin (Stz) in Diabetic Animal Model

Baharuddin,

Ikawaty

2023

j.doc.inf.sci.

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Bibliometric analysis is a relatively new tool in healthcare and therefore does not yet make full use of its potential. This statistical tool analyses scientific publications which further describe trends in academic literature and research in various fields. This study focused on the development of diabetes research using animal models induced by streptozotocin (STZ), a diabetogenic molecule that triggers DNA damage in pancreatic beta cells and causes extreme oxidative stress. 1090 related articles published between 2017-2022 were obtained from the Scopus-Elsevier database using specific keywords “streptozotocin or STZ, animal models, diabetes, intraperitoneal”. Statistical analysis showed 1.67% Annual Growth Rate of publication with 10.66 citation rate per document. Co-occurrence analysis also successfully visualized the main topics related to the mechanism of action of streptozotocin such as oxidative stress, inflammation, rats, diabetic nephropathy, diabetic cardiomyopathy, hyperglycemia, antioxidants, and insulin. An important finding in this study indicated the diabetes research development was not in line with the main problem using animal models that remain unsolved, especially in diabetes research related to pancreatic beta cell proliferation. The result also provided valuable insights of research trends that involved diabetic animal models. The latest research datas are significantly important since it can be used for future research development. Further, more comprehensive information could be achieved by using other databases such as Web of Science (WOS) and Dimension in bibliometric analysis.

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Section: Co-occurrence Visualizationsupporting

confidence: 85%

Bibliometric Analysis: the Use of Streptozotocin (Stz) in Diabetic Animal Model

Baharuddin,

Ikawaty

2023

j.doc.inf.sci.

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Synergistic effects of melatonin and hydrogen sulfide in alleviating cognitive decline and BDNF dysregulation in a rat model of depression

Samir,

Nada,

Meriam

et al. 2024

Egyptian Journal of Basic and Applied Sciences

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The protective effect of Lemon Peel Essential Oil on Pancreas and Brain Oxidative Stress and Inflammation induced by Streptozotocin-Nicotinamide in rats: Behavioral and Biochemical Evidences

Aboubi M,

et al. 2023

RJPT

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The objective of this study is to investigate the effects of Moroccan lemon peel essential oil (LPEO) on various aspects such as anti-hyperglycemic, anti-inflammatory, antioxidant, and anxiolytic activities in diabetic rats. The animals were divided into five groups: normal control group, diabetic control group, diabetic group treated with metformin (300mg/kg), and two diabetic groups treated with LPEO at doses of 0.6ml/kg and 1.2ml/kg, respectively. T2DM was induced in the rats by administering intraperitoneal injections of Streptozotocin and Nicotinamide. Treatment with LPEO or metformin was initiated immediately after confirming the presence of hyperglycemia and continued for a duration of four weeks. Anxiety-related behavior in the rats was assessed using two behavioral tests. 24 hours after conducting the behavioral tests, all rats were anesthetized, and blood samples were taken for the analysis of lipid parameters. The pancreas and brain were dissected to assess TNF-alpha, SOD, and MDA levels. Treatments with LPEO contributed significantly to the preservation of lipid profile and reduction of the atherosclerosis index in diabetic rats (p<.05). Additionally, there was a notable decrease in MDA and TNF-α concentration in the pancreas and brain of diabetic rats treated with LPEO associated with a remarkable increase in SOD activity in the pancreas and brain compared to diabetic control group (p<.05). Lastly, both LPEO and metformin treatments demonstrated significant improvements in anxiety-related behavior in this rat model (p<.05). These positive effects could potentially be attributed to the potent antioxidant and anti-inflammatory activities of both treatments.

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Insulin supplemented with phenolic fraction concentrates displays anxiolytic and antidepressant-like properties with reductions of oxidative brain damage in chronically stressed diabetic rats

Cited by 3 publications

References 61 publications

Bibliometric Analysis: the Use of Streptozotocin (Stz) in Diabetic Animal Model

Bibliometric Analysis: the Use of Streptozotocin (Stz) in Diabetic Animal Model

Synergistic effects of melatonin and hydrogen sulfide in alleviating cognitive decline and BDNF dysregulation in a rat model of depression

The protective effect of Lemon Peel Essential Oil on Pancreas and Brain Oxidative Stress and Inflammation induced by Streptozotocin-Nicotinamide in rats: Behavioral and Biochemical Evidences

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