Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood–Brain Barrier
Andrew L. Zhou,
Suresh K. Swaminathan,
Vrishali S. Salian
et al.
Abstract:The blood–brain barrier (BBB) is instrumental
in clearing
toxic metabolites from the brain, such as amyloid-β (Aβ)
peptides, and in delivering essential nutrients to the brain, like
insulin. In Alzheimer’s disease (AD) brain, increased Aβ
levels are paralleled by decreased insulin levels, which are accompanied
by insulin signaling deficits at the BBB. Thus, we investigated the
impact of insulin-like growth factor and insulin receptor (IGF1R and
IR) signaling on Aβ and insulin trafficking at the BBB. Following
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