Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease

Pardeshi, Rohit; Bolshette, Nityanand; Gadhave, Kundlik; Ahire, Ashutosh; Ahmed, Sahabuddin; Cassano, Tommaso; Gupta, Veer; Lahkar, Mangala

doi:10.1016/j.psyneuen.2017.05.004

Cited by 55 publications

(43 citation statements)

References 127 publications

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“…35 As soon as an individual adopts an unhealthy dietary pattern, his mental functions could be exposed to negative anatomical variations in critical brain areas, such as the hippocampus. 36,37 Vascular impairments, because of glycemic alterations, may have a role in the development of dementia 38 and psychiatric conditions. 22 Cognitive deficits were found in individuals consuming sugar-sweetened beverages.…”

Section: The Reciprocal Relationship Between Diet and Neuropsychiatrimentioning

confidence: 99%

<p>Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice</p>

Briguglio¹,

Vitale²,

Galentino³

et al. 2020

NDT

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Neuropsychiatric disorders stem from gene-environment interaction and their development can be, at least in some cases, prevented by the adoption of healthy and protective lifestyles. Once full blown, neuropsychiatric disorders are prevalent conditions that patients live with a great burden of disability. Indeed, the determinants that increase the affliction of neuropsychiatric disorders are various, with unhealthy lifestyles providing a significant contribution in the interplay between genetic, epigenetic, and environmental factors that ultimately represent the pathophysiological basis of these impairing conditions. On one hand, the adoption of Healthy Eating education, Physical Activity programs, and Sleep hygiene promotion (HEPAS) has the potential to become one of the most suitable interventions to reduce the risk to develop neuropsychiatric disorders, while, on the other hand, its integration with pharmacological and psychological therapies seems to be essential in the overall management of neuropsychiatric disorders in order to reduce the disability and improve the quality of life of affected patients. We present an overview of the current evidence in relation to HEPAS components in the prevention and management of neuropsychiatric disorders and provide suggestions for clinical practice.

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Section: The Reciprocal Relationship Between Diet and Neuropsychiatrimentioning

confidence: 99%

<p>Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice</p>

Briguglio¹,

Vitale²,

Galentino³

et al. 2020

NDT

View full text Add to dashboard Cite

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“…Hippocampal dysfunction and structural compromise are one of the early signs during AD onset [87-91]. Insulin plays a very important role in AD progression by various complex mechanisms [92]. Insulin regulates body homeostasis, synaptic plasticity and causes aging-related neurodegeneration [93] but the precise mechanisms linking AD pathogenesis to the impaired insulin signaling/altered glucose metabolism are not clear [94].…”

Section: Endocrinal Dysregulations In the Ad Pathophysiologymentioning

confidence: 99%

“…Glucose uptake and regional cerebral perfusion are impaired in AD [108]. The impaired cerebral glucose metabolism disrupts the Aβ regulation and synaptic maintenance resulting in elevated inflammation, which leads to neurodegeneration [92]. Hyperglycemia causes neuronal death which leads to certain neurodegenerative diseases but the exact mechanism is poorly understood.…”

Section: Endocrinal Dysregulations In the Ad Pathophysiologymentioning

confidence: 99%

“…There is also downregulation of genes related to glycolysis, the Krebs cycle and oxidative phosphorylation in the transgenic murine model of AD and AD patients [112]. Alterations in enzymes like the pyruvate dehydrogenase complex and α-ketoglutarate dehydrogenase complex have a significant effect on glucose metabolism via the Krebs cycle and oxidative phosphorylation in the brain of AD patients [92]. The possible mechanism for the role of impaired insulin/glucose metabolism in the progression of AD is given in Figure 1.…”

Section: Endocrinal Dysregulations In the Ad Pathophysiologymentioning

confidence: 99%

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Role of Hypothalamic-Pituitary-Adrenal Axis, Hypothalamic-Pituitary-Gonadal Axis and Insulin Signaling in the Pathophysiology of Alzheimer’s Disease

Ahmad

Fatima

Mondal³

2019

Neuropsychobiology

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Alzheimer’s disease (AD), the commonest progressive neurodegenerative disorder of the brain, is clinically characterized by the formation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Recent studies suggest a relationship between the endocrinal dysregulation and the neuronal loss during the AD pathology. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis regulating circulating levels of glucocorticoid hormones has been implicated in the pathophysiology of AD. Likewise, dysregulated insulin signaling, impaired glucose uptake and insulin resistance are some of the prime factors in the onset/progression of AD. In this review, we have discussed the changes in HPA and HPG axes, implicated insulin resistance/signaling and glucose regulation during the onset/progression of AD. Therefore, simultaneous detection of these endocrinal markers in the early or presymptomatic stages may help in the early diagnosis of AD. This evidence for implicated endocrinal functions supports the fact that modulation of endocrinal pathways can be used as therapeutic targets for AD. Future studies need to determine how the induction or inhibition of endocrinal targets could be used for predictable neuroprotection in AD therapies.

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“…Alzheimer's disease (AD) is a chronic neurodegenerative disease that is recognized by cognitive and memory impairment. It most often begins in people over 65 years of age [1]. Being acknowledged as the most common form of dementia, it is considered as one of the massive societal tragedies.…”

Section: Introductionmentioning

confidence: 99%

The Use of Anti-Diabetic Drugs in Alzheimer’s Disease, New Therapeutic Options and Future Perspective

Ibrahim¹,

Hassan²

2018

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Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by progressive loss of memory, confusion, inability of speech and decline in the cognitive behavior. It is considered one of the most common forms of dementia. Clinical studies and preclinical data in the last decade proved that AD and Diabetes mellitus share a pathophysiological pathway, indicating that insulin resistance, oxidative stress and inflammatory response would increase the risks of developing AD in diabetic patients. This review presents briefly the etiology of AD and Diabetes, discusses the possible theories about the interplaying risk factors and the mechanism of action of anti-diabetic medications recommended for the treatment of AD. It is concluded that antidiabetics have good potential to improve dementia, especially in earlier AD stages. However, many of the underlying intricate molecular pathways are still unclear and thus thorough future research is required.

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Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease

Cited by 55 publications

References 127 publications

<p>Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice</p>

<p>Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice</p>

Role of Hypothalamic-Pituitary-Adrenal Axis, Hypothalamic-Pituitary-Gonadal Axis and Insulin Signaling in the Pathophysiology of Alzheimer’s Disease

The Use of Anti-Diabetic Drugs in Alzheimer’s Disease, New Therapeutic Options and Future Perspective

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