Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men

Pelikánová, Terezie; Kohout, M; Válek, J; Baśe, J; Kazdová, Ludmila

doi:10.1016/0026-0495(89)90261-8

Cited by 92 publications

(40 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These showed that the consumption of saturated fat was inversely related to insulin sensitivity and glucose tolerance, whereas a positive association was found for unsaturated fat [1][2][3]. Similar results were found for fatty acid composition in serum [4,5]. In addition, prospective studies in healthy subjects have shown that a serum fatty acid profile of high saturated fatty acids or low unsaturated fatty acids can predict the development of type 2 diabetes [1,6,7].…”

Section: Introductionmentioning

confidence: 77%

Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis The aim of this study was to investigate whether lifestyle intervention-induced changes in serum fatty acid profile of cholesteryl esters and estimated desaturase activities are related to improvements in insulin sensitivity in subjects at risk of type 2 diabetes. Materials and methods In the Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM), 97 men and women with IGT were randomised to a combined diet and exercise programme (47 intervention) or a control group (50 control subjects). At baseline and after 1 year the following assessments were made: an OGTT, an exercise test to determine maximal aerobic capacity, anthropometry, and analysis of the serum fatty acid profile of cholesteryl esters. Results The lifestyle programme was effective in reducing the intake of total and saturated fat, increasing physical activity, reducing obesity and improving insulin sensitivity and glucose tolerance. Regression analysis of the total population showed that an increase in the C20:4 n-6/C20:3 n-6 ratio (estimated Δ5-desaturase activity) and reductions in the C18:3 n-6/C18:2 n-6 ratio (estimated Δ6-desaturase activity) and the C16:1 n-7/C16:0 ratio (estimated Δ9-desaturase activity or stearoyl-CoA desaturase-1) were significantly associated with a decrease in homeostasis model assessment for insulin resistance. After adjustment for lifestyle changes (change in percentage body fat, aerobic capacity and saturated fat intake), these associations were partly reduced, but remained statistically significant. Conclusions/interpretation Lifestyle-induced changes in fatty acid profile of cholesteryl esters and desaturase activities were independently related to changes in insulin sensitivity in subjects at risk of type 2 diabetes.

show abstract

Section: Introductionmentioning

confidence: 77%

Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study

et al. 2006

View full text Add to dashboard Cite

show abstract

“…It has been reported that DHA might play a more prominent role than EPA in Asian populations due to the 10 fold higher concentration of DHA than EPA and the significant correlation of DHA to HDL-C positively, and LDL-C and apolipoprotein B, negatively [13]. In addition, the level of linoleic acid metabolites is consistently lower in erythrocytes of diabetic patients [14], and arachidonic acid (AA), one of the ω-6 fatty acids, has been reported to be associated with decreased insulin sensitivity [15]. SFA level was significantly increased in the DM group ( p b 0.05, Table 2), which could be attributed to the conversion of unused carbohydrates to SFA inside the body [16].…”

Section: Discussionmentioning

confidence: 99%

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Rhee

Paik

Kim

et al. 2008

Clinica Chimica Acta

View full text Add to dashboard Cite

“…Purified EPA ethyl ester reduced insulin resistance and decreased the incidence of type 2 DM in OLETF and WBN=Kob rats respectively (models of spontaneous type 2 DM) by modifying the phospholipid fatty acid composition of the skeletal membrane (Mori et al, 1997;Nobukata et al, 2000). The observation that (a) there is a significant correlation between insulin secretion and action and AA (Pelikanova et al, 1989), (b) an inverse relationship exists between fasting plasma insulin and the percentage of AA in erythrocyte fatty acids (Clifton & Nestel, 1998), and (c) decreased insulin sensitivity is associated with decreased concentrations of PUFAs in skeletal muscle phospholipids in normal men (Borkman et al, 1993) suggests that PUFAs can modulate insulin sensitivity and insulin resistance. It was reported that long-term (6 months) fish oil (a rich source of EPA and DHA) supplementation to patients with type 2 DM did not produce any significant changes in blood glucose and insulin-mediated glucose uptake (Rivellese et al, 1996).…”

Section: Lcpufas and Type 2 Diabetes Mellitusmentioning

confidence: 99%

Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?

Das¹

2003

Eur J Clin Nutr

View full text Add to dashboard Cite

It is suggested that the negative correlation between breast-feeding and insulin resistance and diabetes mellitus can be related to the presence of significant amounts of long-chain polyunsaturated fatty acids in the human breast milk. Based on this, it is proposed that provision of adequate amounts of long chain polyunsaturated fatty acids during the critical periods of brain growth and development can prevent or postpone the development diabetes mellitus.

show abstract

Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men

Cited by 92 publications

References 32 publications

Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study

Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?

Contact Info

Product

Resources

About