Insulin Response in Relation to Insulin Sensitivity

Goedecke, Julia H.; Dave, Joel A.; Faulenbach, Mirjam; Utzschneider, Kristina M.; Lambert, Estelle V.; West, Sacha; Collins, Malcolm; Olsson, Tommy; Walker, Brian R.; Seckl, Jonathan R.; Levitt, Naomi

doi:10.2337/dc08-2048

Cited by 93 publications

(89 citation statements)

References 23 publications

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“…Secondary aim of such medications is to prevent long-term diabetic complications as described eatrlier by eliminating various risk factors [7]. Insulin resistance, a common accompaniment of obesity, is a major risk factor for diabetes mellitus [8]. Because synthetic chemical drugs prescribed for treating obesity and diabetes had many adverse side effects; therefore, there is a great need to search for complementary alternative medicine, particularly from medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Study of Antiobesity Activity of Polyherbal Formulation in Correlation With Antidiabetic Activity

Deepak

Jain

2018

Asian J Pharm Clin Res

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Objective: The objective of this research was to develop a polyherbal formulation using four different herbs using obese diabetic rat's model. Methods:Rats received high-fat diet and alloxan was injected intraperitoneal to rats for induction of diabetes. In the preventive experiment, diabetic rats received Momordica charantia Linn. Results:The results showed that the extract of M. charantia Linn., E. jambolana Linn., Z. mauritiana, and AC significantly (p<0.05) inhibited body weight gain, blood glucose, triglyceride, total cholesterol, low-density lipoprotein (LDL), very LDL, high-density lipoprotein cholesterol, serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, and fasting blood glucose in a dose-dependent manner. Extracts treated rats at doses of 200 and 400 mg/kg improved dyslipidemia in high-fat diet (HFD)-induced obese rats by enhancing their lipid metabolism when compared to the HFD control. Conclusion:The results obtained in this research work clearly showed that taken together the extract of M. charantia Linn., E. jambolana Linn., Z. mauritiana Lam. AC Willd., and aqueous extract of all extracts has potential as a preventive agent for type 2 diabetes mellitus (and possibly obesity) and deserves clinical trial in the near future.

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Section: Introductionmentioning

confidence: 99%

Study of Antiobesity Activity of Polyherbal Formulation in Correlation With Antidiabetic Activity

Deepak

Jain

2018

Asian J Pharm Clin Res

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“…In addition, there are many other studies that have reported that insulin sensitivity as measured by the minimal model is 40 -50% lower in African Americans (2,16,20,23,27,39,40,46). To compare our findings with previous studies, we performed a pooled analysis of studies that included women or predominantly women (2,16,18,20,23,27,39,40,46). S I mean [95% confidence interval (CI)] in African Americans was lower than whites [African Americans: 3.1 (2.3-3.7), n ϭ 848; whites: 5.1 (3.6 -6.5), n ϭ 1,164].…”

Section: Study Design and Clinical Characteristics Of Study Participantsmentioning

confidence: 99%

Postprandial endothelial function does not differ in women by race: an insulin resistance paradox?

Muniyappa

Sachdev

Sidenko

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

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Muniyappa R, Sachdev V, Sidenko S, Ricks M, Castillo DC, Courville AB, Sumner AE. Postprandial endothelial function does not differ in women by race: an insulin resistance paradox? Am J Physiol Endocrinol Metab 302: E218 -E225, 2012. First published November 1, 2011; doi:10.1152/ajpendo.00434.2011.-Insulin resistance is associated with endothelial dysfunction. Because AfricanAmerican women are more insulin-resistant than white women, it is assumed that African-American women have impaired endothelial function. However, racial differences in postprandial endothelial function have not been examined. In this study, we test the hypothesis that African-American women have impaired postprandial endothelial function compared with white women. Postprandial endothelial function following a breakfast (20% protein, 40% fat, and 40% carbohydrate) was evaluated in 36 (18 AfricanAmerican women, 18 white women) age-and body mass index (BMI)-matched (age: 37 Ϯ 11 yr; BMI: 30 Ϯ 6 kg/m 2 ) women. Endothelial function, defined by percent change in brachial artery flow-mediated dilation (FMD), was measured at 0, 2, 4, and 6 h following a meal. There were no significant differences between the groups in baseline FMD, total body fat, abdominal visceral fat, and fasting levels of glucose, insulin, total cholesterol, low-density lipoprotein cholesterol, or serum estradiol. Although AfricanAmerican women were less insulin-sensitive [insulin sensitivity index (mean Ϯ SD): 3.6 Ϯ 1.5 vs. 5.2 Ϯ 2.6, P ϭ 0.02], both fasting triglyceride (TG: 56 Ϯ 37 vs. 97 Ϯ 49 mg/dl, P ϭ 0.007) and incremental TG area under the curve (AUC0 -6hr: 279 Ϯ 190 vs. 492 Ϯ 255 mg·dl Ϫ1 ·min Ϫ1 ·10 Ϫ2 , P ϭ 0.008) were lower in African-American than white women. Breakfast was associated with a significant increase in FMD in whites and African-Americans, and there was no significant difference in postprandial FMD between the groups (P Ͼ 0.1 for group ϫ time interactions). Despite being insulin-resistant, postprandial endothelial function in African-American women was comparable to white women. These results imply that insulin sensitivity may not be an important determinant of racial differences in endothelial function.African Americans; endothelial function AFRICAN-AMERICAN WOMEN SUFFER disproportionately from greater cardiovascular (CV) morbidity and mortality when compared with white women (15). In addition to differences in cultural issues, socioeconomic status, and access to health care, traditional cardiometabolic risk factors such as hypertension, diabetes, obesity, smoking, and physical inactivity disproportionately affecting African-American women contribute to the increased cardiovascular disease (CVD) risk (1, 15). Insulin resistance is independently related to cardiac and vascular function and augments CVD risk in African Americans with hypertension (13). Because African-American women are insulin-resistant compared with white women, they are highly susceptible to develop CVD.Endothelial dysfunction characterized by reduced nitric oxide (NO)-dependent vasc...

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“…The insulinogenic index (IGI) is a frequently used index of β-cell function. It is an index of insulin secretion derived from OGTT (Goedecke et al, 2009). The significant increase in insulinogenic index began from the second week and reached its maximum at weeks 4, 5 and 6.…”

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confidence: 99%

Effect of the Hydroalcoholic Extract of Olea Europea Leaves on Glucose Tolerance and Plasma Lipid Profile in Alloxan-Induced Diabetic Rats.

Elbadrawy¹,

Alblihed²

2017

IJAR

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Insulin Response in Relation to Insulin Sensitivity

Cited by 93 publications

References 23 publications

Study of Antiobesity Activity of Polyherbal Formulation in Correlation With Antidiabetic Activity

Study of Antiobesity Activity of Polyherbal Formulation in Correlation With Antidiabetic Activity

Postprandial endothelial function does not differ in women by race: an insulin resistance paradox?

Effect of the Hydroalcoholic Extract of Olea Europea Leaves on Glucose Tolerance and Plasma Lipid Profile in Alloxan-Induced Diabetic Rats.

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