Insulin Resistance Syndrome in Children

Décsi, Támas; Molnár, Dénes

doi:10.2165/00128072-200305050-00002

Cited by 20 publications

(7 citation statements)

References 92 publications

(24 reference statements)

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“…Likewise increased hepatic lipase activity can account for the rise in high-density lipoprotein depuration, producing hypoalphalipoproteinemia [31]. However, the high prevalence of low C-HDL levels observed in this study is one of the highest reported in the literature [13,30,32].…”

Section: Discussionmentioning

confidence: 73%

Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents

Juárez-López¹,

Klünder-Klünder

Medina-Bravo

et al. 2010

BMC Public Health

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BackgroundInsulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents.MethodsAn analytical, cross-sectional and population-based study was performed in forty-four public primary schools in Campeche City, Mexico. A total of 466 obese children and adolescents between 11-13 years of age were recruited. Fasting glucose and insulin concentrations, high density lipoprotein cholesterol, triglycerides, waist circumference, systolic and diastolic blood pressures were measured; insulin resistance and metabolic syndrome were also evaluated.ResultsOut of the total population studied, 69% presented low values of high density lipoprotein cholesterol, 49% suffered from abdominal obesity, 29% had hypertriglyceridemia, 8% presented high systolic and 13% high diastolic blood pressure, 4% showed impaired fasting glucose, 51% presented insulin resistance and 20% metabolic syndrome. In spite of being obese, 13% of the investigated population did not present any metabolic disorder. For each one of the components of the metabolic syndrome, when insulin resistance increased so did odds ratios as cardiometabolic risk factors.ConclusionsRegardless of age and gender an increased degree of insulin resistance is associated with a higher prevalence of disorders in each of the components of the metabolic syndrome and with a heightened risk of suffering metabolic syndrome among obese children and adolescents.

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Section: Discussionmentioning

confidence: 73%

Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents

Juárez-López¹,

Klünder-Klünder

Medina-Bravo

et al. 2010

BMC Public Health

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“…It is well-documented that sedentary lifestyle is associated with childhood obesity [28]. In our study, physical activity was linked to WC, as an anthropometric measure of abdominal obesity.…”

Section: Discussionmentioning

confidence: 89%

Association of Physical Activity and the Metabolic Syndrome in Children and Adolescents: CASPIAN Study

Kelishadi¹,

Razaghi²,

Gouya³

et al. 2006

Horm Res Paediatr

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Background/Aim: To determine the association of physical activity and the metabolic syndrome in a large national-representative sample of children. Methods: This study was performed in 2003–2004 on 4,811 school students aged 6–18 years, selected by multi-stage random cluster sampling from six provinces in Iran. We assessed the level of physical activity using a standardized questionnaire, and categorized it to the tertiles. The metabolic syndrome was defined based on criteria analogous to those of the Adult Treatment Panel III. Results: The participants comprised 2,248 boys and 2,563 girls with a mean age of 12.07 ± 3.2 years. In all age groups, boys were more physically active than girls. The metabolic syndrome was detected in 14.1% of participants, and its prevalence was higher in those subjects in the 1st, 2nd and 3rd tertiles of physical activity, respectively (15.1 vs.14.2 and 13.1%, respectively, p <0.05). This difference was seen in boys, while no difference was found between girls in the 2nd and 3rd tertiles of physical activity. Physical activity was linked to a cluster of factors consisting of high-density lipoprotein-cholesterol and waist circumference, followed by triglycerides in boys, and of triglycerides, waist circumference and blood pressure in girls. In both genders, before and after adjustment for age and body mass index, low levels of physical activity significantly increased the risk of having the metabolic syndrome [in boys: OR: 1.8, 95% CI: 1.1, 2.1; and in girls, OR: 1.6 (1.1, 1.9)]. Conclusion: We found an association between physical activity and the metabolic syndrome, which was independent of body mass index and age. Children should be encouraged to have greater physical activity.

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“…Insulin also enhances triglyceride (triacylglycerol) synthesis in liver and adipose tissues, increases the breakdown of circulating lipoproteins by stimulating lipoprotein lipase activ- ity in adipose tissues, and suppresses lipolysis both in adipose tissues and in muscles. 23,24 …”

Section: Discussionmentioning

confidence: 99%

Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents

Keskın¹,

Kurtoğlu²,

Kendirci³

et al. 2005

Pediatrics

911

643

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ABSTRACT. Objective. Simple fasting methods to measure insulin resistance, such as the homeostasis model assessment (HOMA), fasting glucose/insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI) methods, have been widely promoted for adult studies but have not been evaluated formally among children and adolescents. The aim of this study was to compare the HOMA, FGIR, and QUICKI methods for measuring insulin resistance, expressed by oral glucose tolerance test (OGTT) results, among obese children and adolescents.Methods. Fifty-seven pubertal obese children and adolescents (30 girls and 27 boys; mean age, 12.04 ؎ 2.90 years; mean BMI: 29.57 ؎ 5.53) participated in the study. All participants underwent an OGTT. Blood samples were obtained 0, 30, 60, 90, and 120 minutes after oral glucose administration for glucose and insulin measurements, and 2 separate groups were studied, according to the presence or absence of insulin resistance. HOMA, FGIR, and QUICKI methods were studied for validation of insulin resistance determined with the OGTT for these groups.Results. The groups consisted of 25 obese children and adolescents with insulin resistance (14 girls and 11 boys; mean age: 12.88 ؎ 2.88 years; mean BMI: 31.29 ؎ 5.86) and 32 subjects without insulin resistance (16 girls and 16 boys; mean age: 11.38 ؎ 2.79 years; mean BMI: 28.23 ؎ 4.94). There were significant differences in the mean HOMA (6.06 ؎ 4.98 and 3.42 ؎ 3.14, respectively) and QUICKI (0.313 ؎ 0.004 and 0.339 ؎ 0.004, respectively) values between the 2 groups. Sensitivity and specificity calculations based on insulin resistance with receiver operating characteristic curve analysis indicated that HOMA had high sensitivity and specificity for measuring insulin resistance.Conclusions.

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Insulin Resistance Syndrome in Children

Cited by 20 publications

References 92 publications

Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents

Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents

Association of Physical Activity and the Metabolic Syndrome in Children and Adolescents: CASPIAN Study

Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents

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