Insulin Resistance, Resistin Hormone and Hepatocellular Carcinoma Interplay: A Review Article

Abstract

Background: The incidence rate of hepatocellular carcinoma (HCC) has risen in the last ten years, increasing the disease's burden in Egypt. Insulin resistance is a pathophysiological condition characterised by decreased insulin action in peripheral target tissues such as skeletal muscle, liver, and adipose tissue. Insulin resistance is thought to play a key role in the development of fibrosis as well as an increase in the risk of HCC. Objective: To assess the possible relation between serum levels of resistin and HCC in patients suffering of liver cirrhosis. Methods: PubMed, Egyptian Knowledge Bank, Google Scholar, were used to search for information on Hepatocellular carcinoma, Insulin resistance and Resistin. The authors also analysed references from relevant literature, but only the most recent or thorough study from May 2005 to October 2021 was included. Documents in languages other than English were excluded because there were insufficient translation-related sources. Dissertations, oral presentations, unpublished manuscripts, conference abstracts, and other works not related to major scientific research were removed. Conclusion:In conclusion, serum resistin level may serve as a new diagnostic marker for HCC patients, however, its accuracy in detection of early focal lesions and prognosis of these patients should be assessed in further larger studies.

Insulin Resistance: The Increased Risk of Cancers

“…Hyperinsulinemia also increases pancreatic, breast, and any cancer mortality [274][275][276][277][278][279]. Increased risk of cancer due to hyperinsulinemia may be caused by both endogenous (prediabetes, metabolic syndrome, obesity, T2DM) and exogenous hyperinsulinemia (insulin therapy for diabetes mellitus) [28,280,281]. Associations between hyperinsulinemia, due to IR, and cancer risk were confirmed in the case of EC [112,282].…”

Investigating the Role of Leptin, Resistin, and Irisin Levels as Prognostic Indicators in Iraqi Lung Cancer Patients

“…Resistin pro-in ammatory cytokine, which is mainly secreted from monocytes, dendritic cells, and macrophages in humans [9]. Resistin may be involved in many in ammatory and autoimmune processes, including cancer, in ammatory bowel disorders, and atherosclerosis, according to Increasing recent research [10]. There is still a dearth of information on resistin's relationship to various cancer types, despite prior research demonstration of this relationship [9,11].…”

“…There is still a dearth of information on resistin's relationship to various cancer types, despite prior research demonstration of this relationship [9,11]. According to one study, resistin and leptin might play a role in the development and spread of lung cancer [10]. Although resistin is less well studied and contentious in lung cancer, the amount of expression of this protein in cancer tissues has not been assessed in many papers [12].…”