Insulin resistance is associated with high-risk coronary artery plaque composition in asymptomatic men between 65 and 75 years and no diabetes: A DANCAVAS cross-sectional sub-study

Larsson, Johanna; Auscher, Søren; Shamoun, André; Pararajasingam, Gokulan; Heinsen, Laurits Juhl; Andersen, Thomas Rueskov; Lindholt, Jes Sanddal; Diederichsen, Axel Cosmus Pyndt; Lambrechtsen, Jess; Egstrup, Kenneth

doi:10.1016/j.atherosclerosis.2023.117328

Cited by 6 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HOMA-IR is an indicator used to evaluate an individual’s IR level but it is expensive. The HOMA-IR was calculated as fasting insulin (μU/mL) × fasting plasma glucose (mg/dL)/405 ( 23 ). We used ePWV to evaluate arterial stiffness.…”

Section: Methodsmentioning

confidence: 99%

Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease

Song,

Ma,

Yin

2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundThe estimated glucose disposal rate (eGDR), an effective indicator of insulin resistance, has been related to acute coronary syndrome, ischemic stroke and heart failure. This study aims to explore the relationship between eGDR and arterial stiffness, all-cause mortality and cardiovascular mortality in patients with non-alcoholic fatty liver disease (NAFLD).MethodsParticipants with NAFLD were chosen from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. The main outcomes are arterial stiffness (represented by estimated pulse wave velocity, ePWV), all-cause and cardiovascular mortality. Multiple cox regression models, restricted cubic spline, sensitivity analysis and subgroup analysis were carried out to investigate the correlation between the insulin resistance indicators and mortality and arterial stiffness. Furthermore, receiver operating characteristic curves were used to compare the predictive value of the eGDR with the triglyceride-glucose (TyG) index and the homeostasis model assessment of insulin resistance (HOMA-IR) for all-cause and cardiovascular mortality.ResultsIn this study, a total of 4,861 participants were included for analysis. After adjusting confounding factors in the multivariate weighted cox regression model, the eGDR was inversely associated with the all-cause mortality (Q4 vs. Q1, HR =0.65 (0.48-0.89, P=0.01) and cardiovascular mortality (Q4 vs. Q1, HR =0.35 (0.19-0.65, P<0.001). Compared with TyG index and HOMA-IR, the eGDR shows excellent predictive value in all-cause mortality (0.588 vs. 0.550 vs. 0.513, P < 0.001) and cardiovascular mortality (0.625 vs. 0.553 vs. 0.537, P < 0.001). In addition, we found a significant negative correlation between eGDR and arterial stiffness (β=-0.13(-0.14–0.11, P< 0.001). However, TyG index and HOMA-IR showed no significant correlation to arterial stiffness.ConclusionsLow eGDR (an indicator of insulin resistance) levels are related to an increased risk of arterial stiffness and mortality in NAFLD patients in the United States.

show abstract

Section: Methodsmentioning

confidence: 99%