Insulin resistance induced by a high-fat diet is associated with the induction of genes related to leukocyte activation in rat peripheral leukocytes

Fujimoto, Saki; Mochizuki, Kazuki; Shimada, Morimi; Hori, Tomoyo; Murayama, Yuki; Ohashi, Norio; Goda, Toshinao

doi:10.1016/j.lfs.2010.10.001

Cited by 17 publications

(8 citation statements)

References 25 publications

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“…Here we showed significant increase in the liver inflammatory marker expression in female offspring at both weaning and adulthood. The association between insulin resistance, hyperglycaemia and increased liver inflammatory cytokine production (such as IL‐1β and IL‐6) has been well documented . The mechanism is suggested to be via the inhibition of 2 essential markers involved in cellular glucose uptake, PPAR‐γ and GLUT4 .…”

Section: Discussionmentioning

confidence: 99%

Maternal L‐carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke

Saad

Aliyu

Chan

et al. 2018

Clin Exp Pharma Physio

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Sex differences in disease susceptibility due to maternal programming have been reported. We previously observed that maternal smoking induced renal disease and neurological changes are restricted to males, while both male and female offspring develop metabolic disorders. We have also found that maternal L-carnitine supplementation during gestation and lactation can significantly improve glucose intolerance and hyperlipidaemia in male offspring. This study aimed to determine whether such beneficial effects can also occur in female offspring. Balb/c female mice were exposed to cigarette smoke (SE) 6 weeks prior to gestation, during gestation and lactation. A subgroup of the SE dams was given L-carnitine (1.5 mmol/L in drinking water) during gestation and lactation. Female offspring were studied at 20 days (weaning) and 13 weeks (adulthood). Maternal smoking increased liver weight (%) and blood glucose levels at 20 days, as well as glucose intolerance and plasma triglycerides levels at adulthood (P < .05). The hepatic lipid metabolic marker adipose triglyceride lipase was downregulated in the SE offspring at 20 days (P < .05). At 13 weeks, the hepatic pro-inflammatory markers IL-1β and TNF-α mRNA expression were upregulated, while the anti-inflammatory marker IL-10 mRNA expression was downregulated in the SE offspring (P < .05). Liver fibrosis was apparent at 20 days and 13 weeks. Maternal L-carnitine supplementation either normalised or suppressed the detrimental effects induced by maternal smoke exposure (P < .05). We conclude that maternal L-carnitine supplementation improves metabolic parameters in the female offspring of SE dams.

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Section: Discussionmentioning

confidence: 99%

Maternal L‐carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke

Saad

Aliyu

Chan

et al. 2018

Clin Exp Pharma Physio

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“…The numbers at the arrows indicate the references in the literature, in which the association between pathway member and pathways/disease phenotype is mentioned. 1 (Guo & Wang, 2009); 2 (Nakashima et al , 2000); 3 (Lazar & Saltiel, 2006); 4 (Ikubo et al , 2009); 5 (Lin et al , 2009); 6 (Tan et al , 2011); 7 (Tsurutani et al , 2011); 8 (Zhang et al , 2006); 9 (Oh & Olefsky, 2010); 10 (Ouchi et al , 2010); 11 (Ross et al , 2000); 12 (Longo et al , 2002); 13 (Christodoulides et al , 2006); 14 (Chavey et al , 2009); 15 (de Roos et al , 2009); 16 (McGillicuddy et al , 2011); 17 (Lagathu et al , 2003); 18 (Rotter et al , 2003); 19 (Bastard et al , 2006); 20 (Yamamoto et al , 2001); 21 (Walia et al , 2003); 22 (Tateya et al , 2010); 23 (Kamei et al , 2006); 24 (Sell and Eckel, 2007); 25 (Clemmons, 2004); 26 (Gronning et al , 2006); 27 (Chen et al , 2011); 28 (Yuasa et al , 2004); 29 (Whiteman et al , 2003); 30 (Alessi et al , 2000); 31 (Garcia-Diaz et al , 2011); 32 (Yu et al , 2011); 33 (Fujimoto et al , 2010); 34 (Mehta et al , 2010); 35 (Bala et al , 2011). …”

Section: Discussionmentioning

confidence: 99%

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren¹,

Linssen²,

Toonen³

et al. 2013

Archives of Physiology and Biochemistry

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Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this are not completely understood. We used a combination of transcriptomics, antibody arrays and bioinformatics approaches to characterize prednisolone-induced alterations in gene expression and adipokine secretion, which could underlie metabolic dysfunction in 3T3-L1 adipocytes. Several pathways, including cytokine signalling, Akt signalling, and Wnt signalling were found to be regulated at multiple levels, showing that these processes are targeted by prednisolone. These results suggest that mechanisms by which prednisolone induce insulin resistance include dysregulation of wnt signalling and immune response processes. These pathways may provide interesting targets for the development of improved glucocorticoids.

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“…However, in most human studies that measured fasting insulin, the study samples were not representative of the normal population because they included a large proportion of overweight subjects [39], [40]. Similarly, in the majority of rodent studies, the animals were overweight [41], genetically obese [42] or on a high-calorie diet [43], [44], which induce both glucose and insulin metabolism disorders and disturbances of in vivo insulin action [45]. Therefore, the correlations identified in the CTL mouse lemurs in this study support the relationships among body mass gain, insulin resistance and the decline of gluco-regulatory functions, all of which may occur even in a normal population without nutritional modification.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus

et al. 2012

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The prevalence of diabetes and hyperinsulinemia increases with age, inducing metabolic failure and limiting lifespan. Calorie restriction (CR) without malnutrition delays the aging process, but its long-term application to humans seems difficult. Resveratrol (RSV), a dietary polyphenol, appears to be a promising CR mimetic that can be easily administered in humans. In this work, we hypothesized that both CR and RSV impact insulin sensitivity in a non-human primate compared to standard-fed control (CTL) animals. Four- to five-year-old male grey mouse lemurs (Microcebus murinus) were assigned to three dietary groups: a CTL group, a CR group receiving 30% fewer calories than the CTL and a RSV group receiving the CTL diet supplemented with RSV (200 mg·day−1·kg−1). Insulin sensitivity and glycemia were assessed using an oral glucose tolerance test (OGTT) and the homeostasis model assessment of insulin resistance (HOMA-IR index) evaluation after 21 or 33 months of chronic treatment. Resting metabolic rate was also measured to assess the potential relationships between this energy expenditure parameter and insulin sensitivity markers. No differences were found after a 21-month period of treatment, except for lower glucose levels 30 min after glucose loading in CR animals. After 33 months, CR and RSV decreased glycemia after the oral glucose loading without decreasing fasting blood insulin. A general effect of treatment was observed on the HOMA-IR index, with an 81% reduction in CR animals and 53% in RSV animals after 33 months of treatment compared to CTL. Chronic CR and dietary supplementation with RSV affected insulin sensitivity by improving the glucose tolerance of animals without disturbing their baseline insulin secretion. These results suggest that both CR and RSV have beneficial effects on metabolic alterations, although these effects are different in amplitude between the two anti-aging treatments and potentially rely on different metabolic changes.

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Insulin resistance induced by a high-fat diet is associated with the induction of genes related to leukocyte activation in rat peripheral leukocytes

Cited by 17 publications

References 25 publications

Maternal L‐carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke

Maternal L‐carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus

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