Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin

Chu, Micheline C.; Cosper, Pippa F.; Orio, Francesco; Carmina, Enrico; Løbo, Rogerio A.

doi:10.1016/j.ajog.2005.06.073

Cited by 90 publications

(65 citation statements)

References 27 publications

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“…Currently, several indices are used for determination of IR in human subjects: M-values determined by various types of glucose clamp, HOMA-IR, ISI-M, quantitative IS check index, K ITT (an index determined by intravenous insulin tolerance test), FPI, SIRI (that is, sum of plasma insulin levels during 75-g OGTT), Belfiore index and Cederholm index. [42][43][44] …”

Section: Discussionmentioning

confidence: 99%

Matsuda–DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno–Sobetsu study

et al. 2011

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Here we examined whether the Matsuda-DeFronzo insulin sensitivity index (ISI-M) is more efficient than the homeostasis model assessment of insulin resistance (HOMA-IR) for assessing risk of hypertension. Cross-sectional and longitudinal analyses were conducted using normotensive subjects who were selected among 1399 subjects in the Tanno-Sobetsu cohort. In the cross-sectional analysis (n ¼ 740), blood pressure (BP) level was correlated with HOMA-IR and with ISI-M, but correlation coefficients indicate a tighter correlation with ISI-M. Multiple linear regression analysis adjusted by age, sex, body mass index (BMI) and serum triglyceride level (TG) showed contribution of ISI-M and fasting plasma glucose, but not of HOMA-IR. In the longitudinal analysis (n ¼ 607), 241 subjects (39.7%) developed hypertension during a 10-year follow-up period, and multiple logistic regression indicated that age, TG, systolic BP and ISI-M, but not HOMA-IR, were associated with development of hypertension. In subjects o60 years old, odds ratio of new-onset hypertension was higher in the low ISI-M group (ISI-M, less than the median) than in the high ISI-M group for any tertile of BMI. In conclusion, ISI-M is a better predictor of hypertension than is HOMA-IR. Non-hepatic IR may be a determinant, which is independent of TG, BP level and BMI, of the development of hypertension.

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Section: Discussionmentioning

confidence: 99%

Matsuda–DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno–Sobetsu study

et al. 2011

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“…O excesso de peso após a menopausa acentua a resistência insulínica e contribui também para o aumento da leptina e da resistina, bem como redução da adiponectina e da ghrelina, o que aumenta ainda mais o risco cardiovascular (22). Outra adipocitocina que se revelou elevada em mulheres pós-menopausa com síndrome metabólica foi a visfatina, observando--se uma elevação tanto maior quanto maior o número de componentes da síndrome metabólica identificados, tendo sido especulado um eventual papel dessa adipocitocina na fisiopatologia da síndrome (23).…”

Section: Obesidadeunclassified

Menopausa e síndrome metabólica

Meirelles

2014

Arq Bras Endocrinol Metab

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RESUMOA incidência de doença cardiovascular aumenta consideravelmente após a menopausa. Um dos motivos para o crescente risco cardiovascular parece ser determinado pela síndrome metabólica, da qual todos os componentes (obesidade visceral, dislipidemia, hipertensão arterial e distúrbio do metabolismo glicídico) se associam à maior incidência de coronariopatia. Após a menopausa, a sín-drome metabólica é mais prevalente do que na pré-menopausa, podendo ter importante papel na ocorrência de infarto do miocárdio e outras morbidades ateroscleróticas e cardiovasculares. A obesidade, componente primordial da síndrome metabólica, se associa ainda ao aumento da incidência de câncer de mama, endométrio, intestino, esôfago e rim. O tratamento da síndrome metabólica se baseia na mudança de hábitos de vida e, quando necessário, no emprego de medicação dirigida aos seus componentes. Na presença de sintomas de síndrome do climatério, a terapia hormonal, quando indicada, concorrerá também para a melhora da síndrome metabólica. Arq Bras Endocrinol Metab. 2014;58(2):91-6Descritores Menopausa; síndrome metabólica; terapia hormonal da menopausa; resistência insulínica; estrogênios ABSTRACTThe incidence of cardiovascular disease increases considerably after the menopause. One reason for the increased cardiovascular risk seems to be determined by metabolic syndrome, in which all components (visceral obesity, dyslipidemia, hypertension, and glucose metabolism disorder) are associated with higher incidence of coronary artery disease. After menopause, metabolic syndrome is more prevalent than in premenopausal women, and may plays an important role in the occurrence of myocardial infarction and other atherosclerotic and cardiovascular morbidities. Obesity, an essential component of the metabolic syndrome, is also associated with increased incidence of breast, endometrial, bowel, esophagus, and kidney cancer. The treatment of metabolic syndrome is based on the change in lifestyle and, when necessary, the use of medication directed to its components. In the presence of symptoms of the climacteric syndrome, hormonal therapy, when indicated, will also contribute to the improvement of the metabolic syndrome. Arq Bras Endocrinol Metab. 2014;58 (2) INTRODUÇÃO A s doenças cardiovasculares são a maior causa de mortalidade em ambos os sexos e sua incidência em mulheres no menacme é menor do que nos homens de mesma idade, diminuindo progressivamente essa diferença com o envelhecimento e o advento da menopausa (1). Considerando-se apenas o sexo feminino, o estudo de Framingham mostrou que a incidência anual de doença cardiovascular em mulheres com menos de 55 anos na pré-menopausa, quando comparada à de mulheres, na mesma faixa etária, nas quais já ocorrera a menopausa, foi cerca de 50% menor (2). A falência ovariana parece, portanto, ser um divisor de águas, em termos de risco cardiovascular.Um dos fatores que aumentam o risco de mortalidade, em homens e mulheres, é a síndrome metabólica. A Third National Health and Nutrition Examination Survey (NH...

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“…Evidence suggests that the risk for insulin resistance increases after menopause, and that it may be related to the decline in estrogen (53) and may be predominantly influenced by BMI (55,56). In fact, postmenopausal accumulation of abdominal fat and obesity promote abnormal adipokine secretion, particularly increasing serum leptin levels, and contribute to insulin resistance (57).…”

Section: Adulthood and Postmenopausementioning

confidence: 99%